CRCGN015_MCF10A.TP53.M_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 96.55 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.8409
ADAM10 ADAM metallopeptidase domain 10 5.00582
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.7771
CCP110 centriolar coiled coil protein 110kDa 4.74855
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.66275
ZNF134 zinc finger protein 134 3.81075
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.45555
ZNF419 zinc finger protein 419 3.163
ZNF304 zinc finger protein 304 3.1023
MELK maternal embryonic leucine zipper kinase 3.02375
ZNF587B zinc finger protein 587B 2.98085
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.96045
ZNF222 zinc finger protein 222 2.9105
PCDHB11 protocadherin beta 11 2.83375
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.73605
ZNF227 zinc finger protein 227 2.66845
GPM6B glycoprotein M6B 2.60248
TTC17 tetratricopeptide repeat domain 17 2.5952
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.532
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.51965
ZNF551 zinc finger protein 551 2.5144
BCL3 B-cell CLL/lymphoma 3 2.50205
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.39505
ZNF671 zinc finger protein 671 2.3785
ZNF548 zinc finger protein 548 2.35315
ZIM3 zinc finger, imprinted 3 2.3509
VPS35L VPS35 endosomal protein sorting factor like 2.3442
CSAD cysteine sulfinic acid decarboxylase 2.27255
ZNF787 zinc finger protein 787 2.25835
CADM1 cell adhesion molecule 1 2.23107
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.22115
FAN1 FANCD2/FANCI-associated nuclease 1 2.1993
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.19715
ZNF224 zinc finger protein 224 2.16855
GRHPR glyoxylate reductase/hydroxypyruvate reductase 2.15622
GDF7 growth differentiation factor 7 2.15445
MINDY2 MINDY lysine 48 deubiquitinase 2 2.15225
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.14335
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.14065
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.1384
ZNF211 zinc finger protein 211 2.12955
RNF14 ring finger protein 14 2.11578
RGPD1 RANBP2-like and GRIP domain containing 1 2.11195
TM6SF1 transmembrane 6 superfamily member 1 2.1069
TTC26 tetratricopeptide repeat domain 26 2.07235
ITM2C integral membrane protein 2C 2.07105
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.061
TDP2 tyrosyl-DNA phosphodiesterase 2 2.0479
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.01925
CREB5 cAMP responsive element binding protein 5 2.01715
PRMT7 protein arginine methyltransferase 7 2.01465
FBXO46 F-box protein 46 2.01085

decreased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A -5.91785
MAPK13 mitogen-activated protein kinase 13 -5.3033
TUBB6 tubulin, beta 6 class V -5.1988
C2CD5 C2 calcium-dependent domain containing 5 -5.1753
KIF14 kinesin family member 14 -4.94575
BASP1 brain abundant, membrane attached signal protein 1 -4.45615
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.0061
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.7632
ACOT9 acyl-CoA thioesterase 9 -2.4218
NGRN neugrin, neurite outgrowth associated -2.3774
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -2.3199
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.2711
LHX6 LIM homeobox 6 -2.2662
TSPAN3 tetraspanin 3 -2.21598
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.1674
QPRT quinolinate phosphoribosyltransferase -2.1283
TENT5A terminal nucleotidyltransferase 5A -2.12455
IL4R interleukin 4 receptor -2.11025
WDR37 WD repeat domain 37 -2.106
CST3 cystatin C -2.0881
FTL ferritin, light polypeptide -2.08722
PRPF38B pre-mRNA processing factor 38B -2.07095
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.0707
SPARCL1 SPARC-like 1 (hevin) -2.0555
MSMO1 methylsterol monooxygenase 1 -2.04305
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.0136
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.0009