CRCGN015_MCF10A.TP53.M_24H:D23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 32.18 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

191 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.6406
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.49475
VAV3 vav 3 guanine nucleotide exchange factor 5.22692
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.0588
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.563
WDR7 WD repeat domain 7 3.9652
TIAM1 T-cell lymphoma invasion and metastasis 1 3.82387
CTSZ cathepsin Z 3.3081
PRKCQ protein kinase C, theta 3.1892
SIRT3 sirtuin 3 2.90585
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.90185
RPAP1 RNA polymerase II associated protein 1 2.83765
RIC8A RIC8 guanine nucleotide exchange factor A 2.83245
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.78245
GTF2IRD1 GTF2I repeat domain containing 1 2.6946
APH1A APH1A gamma secretase subunit 2.6836
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 2.67193
FBXW4 F-box and WD repeat domain containing 4 2.6713
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 2.66592
HMG20A high mobility group 20A 2.5999
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.58155
COPS5 COP9 signalosome subunit 5 2.5588
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.53055
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.5208
RBMS3 RNA binding motif, single stranded interacting protein 3 2.5201
SRSF4 serine/arginine-rich splicing factor 4 2.51595
ARMC1 armadillo repeat containing 1 2.49305
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.48105
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.45285
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.44475
COL2A1 collagen, type II, alpha 1 2.43652
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.4277
SAP130 Sin3A-associated protein, 130kDa 2.40735
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.4024
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.3748
MMP1 matrix metallopeptidase 1 2.34265
LEFTY1 left-right determination factor 1 2.3145
DENND2D DENN/MADD domain containing 2D 2.31115
PFKM phosphofructokinase, muscle 2.27465
ACP2 acid phosphatase 2, lysosomal 2.27015
STX18 syntaxin 18 2.24615
AARSD1 alanyl-tRNA synthetase domain containing 1 2.23085
IGF2 insulin-like growth factor 2 2.22285
SYNE2 spectrin repeat containing, nuclear envelope 2 2.20955
FIG4 FIG4 phosphoinositide 5-phosphatase 2.20045
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.19455
ZNF107 zinc finger protein 107 2.1872
SUOX sulfite oxidase 2.1853
AURKC aurora kinase C 2.1676
EP400 E1A binding protein p400 2.16427
SYNGAP1 synaptic Ras GTPase activating protein 1 2.16022
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 2.15845
PRSS16 protease, serine, 16 (thymus) 2.15665
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.15225
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.141
PMM2 phosphomannomutase 2 2.13015
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.1287
SREBF1 sterol regulatory element binding transcription factor 1 2.1149
CRYBB2 crystallin, beta B2 2.11087
TSKU tsukushi, small leucine rich proteoglycan 2.10195
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.0967
AMBRA1 autophagy/beclin-1 regulator 1 2.0803
KLHDC2 kelch domain containing 2 2.0793
DUOX2 dual oxidase 2 2.07635
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.0717
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.0666
GCN1 GCN1 activator of EIF2AK4 2.06652
PEX5 peroxisomal biogenesis factor 5 2.05565
MMP2 matrix metallopeptidase 2 2.0392
PTCD2 pentatricopeptide repeat domain 2 2.0385
ETAA1 Ewing tumor-associated antigen 1 2.03435
NIT1 nitrilase 1 2.03295
PIBF1 progesterone immunomodulatory binding factor 1 2.03155
PHF21A PHD finger protein 21A 2.02765
BDKRB1 bradykinin receptor B1 2.02145
OAZ2 ornithine decarboxylase antizyme 2 2.02093
EPN2 epsin 2 2.01708
NDC1 NDC1 transmembrane nucleoporin 2.011
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 2.00122

decreased expression

Symbol Name Standardized Value
CDK4 cyclin-dependent kinase 4 -5.83775
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.7895
CDC45 cell division cycle 45 -5.5679
MRPS2 mitochondrial ribosomal protein S2 -5.5376
PLK1 polo-like kinase 1 -5.3826
RNF167 ring finger protein 167 -5.3109
SLC35F2 solute carrier family 35, member F2 -5.2008
UFM1 ubiquitin-fold modifier 1 -5.05815
MSMO1 methylsterol monooxygenase 1 -5.0
PCNA proliferating cell nuclear antigen -5.0
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.51842
CAB39 calcium binding protein 39 -4.43425
BPHL biphenyl hydrolase-like (serine hydrolase) -4.32905
PFN1 profilin 1 -4.28085
DCTD dCMP deaminase -4.14255
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.07595
SGK1 serum/glucocorticoid regulated kinase 1 -3.84335
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -3.73365
TCTA T-cell leukemia translocation altered -3.6668
C1QBP complement component 1, q subcomponent binding protein -3.61363
IDI1 isopentenyl-diphosphate delta isomerase 1 -3.37245
LYPLA1 lysophospholipase I -3.3184
SQLE squalene epoxidase -3.24415
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.23635
GRWD1 glutamate-rich WD repeat containing 1 -3.09335
KDM3A lysine (K)-specific demethylase 3A -3.0713
CHL1 cell adhesion molecule L1-like -3.06815
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.93288
PDLIM2 PDZ and LIM domain 2 (mystique) -2.86935
HOPX HOP homeobox -2.81475
RGS2 regulator of G-protein signaling 2 -2.7771
AK4 adenylate kinase 4 -2.7357
MVD mevalonate (diphospho) decarboxylase -2.72315
NUBPL nucleotide binding protein-like -2.713
DSG1 desmoglein 1 -2.7062
ARMC6 armadillo repeat containing 6 -2.6995
COTL1 coactosin-like F-actin binding protein 1 -2.68995
PRX periaxin -2.60705
LORICRIN loricrin cornified envelope precursor protein -2.6038
GABARAP GABA(A) receptor-associated protein -2.5714
DUX4 double homeobox 4 -2.56035
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.55415
TARS1 threonyl-tRNA synthetase 1 -2.46505
CALCOCO2 calcium binding and coiled-coil domain 2 -2.45645
GRN granulin -2.44992
URM1 ubiquitin related modifier 1 -2.44915
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -2.44205
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.43377
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.4164
IGFBP7 insulin-like growth factor binding protein 7 -2.38385
EMC6 ER membrane protein complex subunit 6 -2.3833
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.37962
SUSD6 sushi domain containing 6 -2.3694
COBL cordon-bleu WH2 repeat protein -2.34695
LTC4S leukotriene C4 synthase -2.3402
EXOC3 exocyst complex component 3 -2.3
ITPRID2 ITPR interacting domain containing 2 -2.2966
ADGRD2 adhesion G protein-coupled receptor D2 -2.29075
EIF6 eukaryotic translation initiation factor 6 -2.25535
CD99 CD99 molecule -2.25125
SLC35B1 solute carrier family 35, member B1 -2.24985
PAIP1 poly(A) binding protein interacting protein 1 -2.24475
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.23685
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.23025
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.20895
PLK2 polo-like kinase 2 -2.18755
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.1826
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.1818
ENTR1 endosome associated trafficking regulator 1 -2.16125
APMAP adipocyte plasma membrane associated protein -2.1584
STOM stomatin -2.15357
TBKBP1 TBK1 binding protein 1 -2.15255
SNX16 sorting nexin 16 -2.15155
ZMAT3 zinc finger, matrin-type 3 -2.1497
AQP4 aquaporin 4 -2.14097
LIMK2 LIM domain kinase 2 -2.13873
PDGFA platelet-derived growth factor alpha polypeptide -2.13808
FKBP6 FK506 binding protein 6, 36kDa -2.1377
NOP56 NOP56 ribonucleoprotein -2.13625
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.1229
NUP153 nucleoporin 153kDa -2.12165
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.1152
KLK6 kallikrein-related peptidase 6 -2.10775
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -2.1037
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.0951
POU3F2 POU class 3 homeobox 2 -2.09015
SUN2 Sad1 and UNC84 domain containing 2 -2.0831
TUBA3C tubulin, alpha 3c -2.0825
SASH3 SAM and SH3 domain containing 3 -2.0805
ELP5 elongator acetyltransferase complex subunit 5 -2.078
MGAM maltase-glucoamylase -2.0732
HLX H2.0-like homeobox -2.0712
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -2.07105
BOLA2B bolA family member 2B -2.0634
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.0603
GSK3B glycogen synthase kinase 3 beta -2.05635
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.05475
SEC61B Sec61 beta subunit -2.05195
ZC3H15 zinc finger CCCH-type containing 15 -2.05035
LHX1 LIM homeobox 1 -2.047
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.04295
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.03195
NDEL1 nudE neurodevelopment protein 1-like 1 -2.03075
MAGT1 magnesium transporter 1 -2.03045
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.0283
SRPRB signal recognition particle receptor, B subunit -2.0147
CYTH3 cytohesin 3 -2.01355
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.0132
LAMA2 laminin, alpha 2 -2.01048
EPN1 epsin 1 -2.0064
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.00565
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.00385