CRCGN015_MCF10A.TP53.M_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 10.73 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 4.93075
IDE insulin-degrading enzyme 4.80205
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.43797
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.34175
FGFR4 fibroblast growth factor receptor 4 4.24833
KIF5C kinesin family member 5C 4.06325
TBX2 T-box 2 3.77247
COQ8A coenzyme Q8A 3.4362
NVL nuclear VCP-like 3.29315
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.27707
BPHL biphenyl hydrolase-like (serine hydrolase) 3.1578
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.12265
STK10 serine/threonine kinase 10 3.09725
RNF167 ring finger protein 167 2.85535
MTA2 metastasis associated 1 family, member 2 2.81275
RBBP5 retinoblastoma binding protein 5 2.7443
MELK maternal embryonic leucine zipper kinase 2.60795
SPDEF SAM pointed domain containing ETS transcription factor 2.49602
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.4918
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.4612
FBXO28 F-box protein 28 2.3635
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.3397
PTPRS protein tyrosine phosphatase, receptor type, S 2.283
WDR26 WD repeat domain 26 2.2768
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.25122
INCENP inner centromere protein antigens 135/155kDa 2.2415
TIPRL TOR signaling pathway regulator 2.22335
TLN1 talin 1 2.18275
CADM1 cell adhesion molecule 1 2.0835
SEPTIN10 septin 10 2.0831
SLC75A1 solute carrier family 75 member 1 2.05985
DEGS1 delta(4)-desaturase, sphingolipid 1 2.04483
TRAPPC6A trafficking protein particle complex 6A 2.04095
MMP2 matrix metallopeptidase 2 2.0222
TMEM123 transmembrane protein 123 2.02185
AIDA axin interactor, dorsalization associated 2.00985

decreased expression

Symbol Name Standardized Value
YME1L1 YME1-like 1 ATPase -3.97573
KRT14 keratin 14, type I -3.5131
CAB39 calcium binding protein 39 -3.18365
ACAA1 acetyl-CoA acyltransferase 1 -3.16062
SORBS3 sorbin and SH3 domain containing 3 -2.68222
PLCD1 phospholipase C, delta 1 -2.5872
ANKRD26 ankyrin repeat domain 26 -2.34833
NGRN neugrin, neurite outgrowth associated -2.26205
REXO2 RNA exonuclease 2 -2.19598
TRIM6-TRIM34 TRIM6-TRIM34 readthrough -2.1713
ABI1 abl-interactor 1 -2.1466
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.0832
CBR3 carbonyl reductase 3 -2.06515
SEPTIN8 septin 8 -2.05835
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.0241
DSG3 desmoglein 3 -2.01295
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -2.00635
PEAK1 pseudopodium-enriched atypical kinase 1 -2.0041