CRCGN015_MCF10A.TP53.M_24H:E03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.92193
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.26555
STIMATE STIM activating enhancer 4.26022
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.39468
METRN meteorin, glial cell differentiation regulator 3.34563
E2F2 E2F transcription factor 2 3.34314
SNAP25 synaptosomal-associated protein, 25kDa 3.33087
SMIM40 small integral membrane protein 40 3.32622
AAMDC adipogenesis associated, Mth938 domain containing 3.26425
BTK Bruton agammaglobulinemia tyrosine kinase 2.79985
WIF1 WNT inhibitory factor 1 2.7678
TLR4 toll-like receptor 4 2.74318
CCL2 chemokine (C-C motif) ligand 2 2.65167
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.63834
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.57968
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.5309
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.43354
ADGRG1 adhesion G protein-coupled receptor G1 2.3419
HLA-DRA major histocompatibility complex, class II, DR alpha 2.33337
RGS4 regulator of G-protein signaling 4 2.28594
RSF1 remodeling and spacing factor 1 2.17614
GBP1 guanylate binding protein 1, interferon-inducible 2.10424
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.10314
CCNA1 cyclin A1 2.07074
DENND2D DENN/MADD domain containing 2D 2.03572
PXDC1 PX domain containing 1 2.02754
NSG2 neuronal vesicle trafficking associated 2 2.00143

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -3.67158
PUF60 poly-U binding splicing factor 60KDa -3.6529
NPDC1 neural proliferation, differentiation and control, 1 -3.55874
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.07683
UBE3C ubiquitin protein ligase E3C -3.02764
CD44 CD44 molecule (Indian blood group) -2.30009
CD81 CD81 molecule -2.26372
CHMP4B charged multivesicular body protein 4B -2.25905
HMG20B high mobility group 20B -2.19178
KIF3B kinesin family member 3B -2.09163
MCF2L MCF.2 cell line derived transforming sequence-like -2.0878
SCRIB scribbled planar cell polarity protein -2.01589
F8A2 coagulation factor VIII-associated 2 -2.00054