CRCGN015_MCF10A.TP53.M_24H:E04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tricresyl phosphate 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.45135
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 5.23435
STK10 serine/threonine kinase 10 5.09723
UBQLN2 ubiquilin 2 5.0232
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.88775
TOMM34 translocase of outer mitochondrial membrane 34 4.08375
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.82915
CCL2 chemokine (C-C motif) ligand 2 3.0797
CNRIP1 cannabinoid receptor interacting protein 1 2.83625
BAMBI BMP and activin membrane-bound inhibitor 2.58405
PARP1 poly (ADP-ribose) polymerase 1 2.5659
HBB hemoglobin, beta 2.51172
LARS1 leucyl-tRNA synthetase 1 2.49175
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.4771
CTTN cortactin 2.40053
BZW2 basic leucine zipper and W2 domains 2 2.3385
HBA1 hemoglobin, alpha 1 2.2456
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.1889
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.15475
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.05128
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.0062

decreased expression

Symbol Name Standardized Value
KLHDC2 kelch domain containing 2 -5.2154
CORO1A coronin, actin binding protein, 1A -5.2149
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.14
MRPS2 mitochondrial ribosomal protein S2 -5.0995
OXA1L oxidase (cytochrome c) assembly 1-like -5.0
ENOPH1 enolase-phosphatase 1 -4.79015
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.7111
ISOC1 isochorismatase domain containing 1 -4.65535
CHIC2 cysteine-rich hydrophobic domain 2 -4.1637
CD320 CD320 molecule -4.13195
HMG20B high mobility group 20B -4.11965
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.75918
PFN1 profilin 1 -3.0116
NRIP1 nuclear receptor interacting protein 1 -2.66737
DCK deoxycytidine kinase -2.46435
GMPR2 guanosine monophosphate reductase 2 -2.43515
TCEA2 transcription elongation factor A (SII), 2 -2.4162
PIH1D1 PIH1 domain containing 1 -2.3214
PAEP progestagen-associated endometrial protein -2.28845
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.28135
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.2387
ENDOG endonuclease G -2.0935
RBMY1J RNA binding motif protein, Y-linked, family 1, member J -2.03555
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.00385