CRCGN015_MCF10A.TP53.M_24H:E07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methenamine 100.46 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.45135
ADAM10 ADAM metallopeptidase domain 10 4.78027
C2CD2 C2 calcium-dependent domain containing 2 4.61055
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 4.18147
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.96167
ACAA1 acetyl-CoA acyltransferase 1 3.6387
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.5296
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.354
HBA1 hemoglobin, alpha 1 3.2629
HLA-DRA major histocompatibility complex, class II, DR alpha 2.98898
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.5644
NOSIP nitric oxide synthase interacting protein 2.324
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 2.31285
MRPL17 mitochondrial ribosomal protein L17 2.257
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2.25635
LACTB2 lactamase, beta 2 2.25115
PTDSS1 phosphatidylserine synthase 1 2.2453
PORCN porcupine homolog (Drosophila) 2.19995
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.13571
RBM7 RNA binding motif protein 7 2.10155
ENDOD1 endonuclease domain containing 1 2.07907
HJURP Holliday junction recognition protein 2.0733
TDP1 tyrosyl-DNA phosphodiesterase 1 2.05245
CTSV cathepsin V 2.00885

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -5.3296
MSMO1 methylsterol monooxygenase 1 -5.0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.95928
TUBB6 tubulin, beta 6 class V -4.92905
TRAPPC3 trafficking protein particle complex 3 -4.48325
DSG2 desmoglein 2 -4.4778
WDR70 WD repeat domain 70 -3.20215
BASP1 brain abundant, membrane attached signal protein 1 -3.03925
STEEP1 STING1 ER exit protein 1 -2.72295
PAIP1 poly(A) binding protein interacting protein 1 -2.52605
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.5251
MYO16 myosin XVI -2.4961
C4A complement component 4A (Rodgers blood group) -2.4893
TPH1 tryptophan hydroxylase 1 -2.4055
TMEM267 transmembrane protein 267 -2.374
TGM4 transglutaminase 4 -2.37118
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -2.32823
POLI polymerase (DNA directed) iota -2.27875
RRAGC Ras-related GTP binding C -2.244
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -2.23215
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.232
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.2309
BRIX1 BRX1, biogenesis of ribosomes -2.22445
SOX9 SRY (sex determining region Y)-box 9 -2.22318
TEX11 testis expressed 11 -2.21355
RNF146 ring finger protein 146 -2.1946
CLTCL1 clathrin, heavy chain-like 1 -2.1888
SNX7 sorting nexin 7 -2.16965
NEK11 NIMA-related kinase 11 -2.16795
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.15033
DROSHA drosha, ribonuclease type III -2.14765
TPSAB1 tryptase alpha/beta 1 -2.12678
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.1158
SNAP29 synaptosomal-associated protein, 29kDa -2.1153
HLA-DOB major histocompatibility complex, class II, DO beta -2.1123
CSRP1 cysteine and glycine-rich protein 1 -2.09458
TMEM74B transmembrane protein 74B -2.0869
ICE1 interactor of little elongation complex ELL subunit 1 -2.0869
GSTCD glutathione S-transferase, C-terminal domain containing -2.08675
EPHB1 EPH receptor B1 -2.07735
NEUROD1 neuronal differentiation 1 -2.07185
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.07135
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.06595
ZNF675 zinc finger protein 675 -2.0625
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -2.0454
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.0422
CPE carboxypeptidase E -2.0383
MAOB monoamine oxidase B -2.0362
TCEAL2 transcription elongation factor A (SII)-like 2 -2.03
ZMAT4 zinc finger, matrin-type 4 -2.0221
LSAMP limbic system-associated membrane protein -2.01705
KIAA0319 KIAA0319 -2.013
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.00405
MAP9 microtubule-associated protein 9 -2.0038