CRCGN015_MCF10A.TP53.M_24H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methenamine 33.49 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.94965
GLOD4 glyoxalase domain containing 4 5.6
LAGE3 L antigen family, member 3 5.56495
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.51225
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.02515
WIF1 WNT inhibitory factor 1 4.66275
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.44125
COMP cartilage oligomeric matrix protein 2.53945
SNAP91 synaptosomal-associated protein, 91kDa 2.4673
VBP1 von Hippel-Lindau binding protein 1 2.4286
CCNA1 cyclin A1 2.3459
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.33225
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 2.30205
ACAN aggrecan 2.29535
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.25835
SAE1 SUMO1 activating enzyme subunit 1 2.2474
AGR2 anterior gradient 2 2.2383
ZMPSTE24 zinc metallopeptidase STE24 2.13585
HLA-DRA major histocompatibility complex, class II, DR alpha 2.11315
SLC10A3 solute carrier family 10, member 3 2.0739
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.03165
RBBP7 retinoblastoma binding protein 7 2.02775
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.00365

decreased expression

Symbol Name Standardized Value
BAG3 BCL2-associated athanogene 3 -5.60445
OXA1L oxidase (cytochrome c) assembly 1-like -5.2153
HMG20B high mobility group 20B -5.20312
UFM1 ubiquitin-fold modifier 1 -5.14205
COG2 component of oligomeric golgi complex 2 -4.9721
UBE3C ubiquitin protein ligase E3C -4.6381
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.18287
ANXA2 annexin A2 -3.86072
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.47502
PTK2 protein tyrosine kinase 2 -3.44207
BCAR3 breast cancer anti-estrogen resistance 3 -3.38535
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.08985
HSPA1A heat shock 70kDa protein 1A -3.0735
CAPN2 calpain 2, (m/II) large subunit -2.87865
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.5965
THTPA thiamine triphosphatase -2.5059
MREG melanoregulin -2.47465
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -2.4412
RAB3A RAB3A, member RAS oncogene family -2.37315
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.3669
MAGEC2 melanoma antigen family C2 -2.34545
DGKD diacylglycerol kinase, delta 130kDa -2.3245
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.26235
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.2557
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.1989
ZNF280D zinc finger protein 280D -2.1809
ACOT13 acyl-CoA thioesterase 13 -2.17465
DACH1 dachshund family transcription factor 1 -2.15688
EXT1 exostosin glycosyltransferase 1 -2.14143
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.1267
MTRF1 mitochondrial translational release factor 1 -2.1171
RNASE6 ribonuclease, RNase A family, k6 -2.10735
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.10275
GNPAT glyceronephosphate O-acyltransferase -2.097
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) -2.0773
MYOG myogenin (myogenic factor 4) -2.0761
SALL2 spalt-like transcription factor 2 -2.0749
CRABP2 cellular retinoic acid binding protein 2 -2.07175
FZD2 frizzled class receptor 2 -2.0676
FNDC3A fibronectin type III domain containing 3A -2.04055
ANG angiogenin, ribonuclease, RNase A family, 5 -2.01855
MUC4 mucin 4, cell surface associated -2.01688
CACTIN cactin, spliceosome C complex subunit -2.0165
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.01517