CRCGN015_MCF10A.TP53.M_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

150 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 6.3927
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 5.50173
WFS1 Wolfram syndrome 1 (wolframin) 5.40095
ADGRE5 adhesion G protein-coupled receptor E5 4.7989
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 4.38645
ALDOC aldolase C, fructose-bisphosphate 4.3807
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 4.02
ACAA1 acetyl-CoA acyltransferase 1 3.83505
AGR2 anterior gradient 2 3.4416
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3.24813
FDFT1 farnesyl-diphosphate farnesyltransferase 1 3.17838
INSIG1 insulin induced gene 1 2.9963
STXBP1 syntaxin binding protein 1 2.8901
TXNL4B thioredoxin-like 4B 2.81225
ACLY ATP citrate lyase 2.76312
WIF1 WNT inhibitory factor 1 2.75
PNKP polynucleotide kinase 3'-phosphatase 2.69475
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.6811
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.62485
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.6144
ECH1 enoyl CoA hydratase 1, peroxisomal 2.59565
S100A4 S100 calcium binding protein A4 2.5612
TAC1 tachykinin, precursor 1 2.5389
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.537
ABHD6 abhydrolase domain containing 6 2.4658
SLC67A1 solute carrier family 67 member 1 2.4435
PKN1 protein kinase N1 2.4411
SARAF store-operated calcium entry-associated regulatory factor 2.4391
ANO1 anoctamin 1, calcium activated chloride channel 2.4209
PROCR protein C receptor, endothelial 2.3871
IL1B interleukin 1, beta 2.3132
GLRX glutaredoxin (thioltransferase) 2.29292
NUCB2 nucleobindin 2 2.2905
DPH2 DPH2 homolog (S. cerevisiae) 2.27405
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.27335
LRP10 low density lipoprotein receptor-related protein 10 2.26525
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.23835
ATG9A autophagy related 9A 2.23565
ACADVL acyl-CoA dehydrogenase, very long chain 2.23225
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.2183
DHCR7 7-dehydrocholesterol reductase 2.20038
TBC1D31 TBC1 domain family, member 31 2.1933
CCDC92 coiled-coil domain containing 92 2.18695
PRAF2 PRA1 domain family, member 2 2.1818
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.153
AAMDC adipogenesis associated, Mth938 domain containing 2.14867
ANO10 anoctamin 10 2.13865
RAB5B RAB5B, member RAS oncogene family 2.132
EPS8 epidermal growth factor receptor pathway substrate 8 2.1299
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.12915
CDPF1 cysteine-rich, DPF motif domain containing 1 2.11885
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.09593
TMEM94 transmembrane protein 94 2.0936
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.08315
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.07955
ADD3 adducin 3 (gamma) 2.07675
FOXO4 forkhead box O4 2.0688
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.05715
CRAT carnitine O-acetyltransferase 2.04743
ANXA4 annexin A4 2.02942
ZNF451 zinc finger protein 451 2.00588
PRR7 proline rich 7 (synaptic) 2.00535

decreased expression

Symbol Name Standardized Value
SLC25A46 solute carrier family 25, member 46 -5.84405
PCNA proliferating cell nuclear antigen -5.49155
TUBB6 tubulin, beta 6 class V -5.0
DCK deoxycytidine kinase -4.52245
SLC35F2 solute carrier family 35, member F2 -4.36215
BID BH3 interacting domain death agonist -4.30155
NT5DC2 5'-nucleotidase domain containing 2 -3.4641
MCM6 minichromosome maintenance complex component 6 -3.4022
KDM3A lysine (K)-specific demethylase 3A -3.34545
RALGDS ral guanine nucleotide dissociation stimulator -3.27015
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.26015
SNRPB2 small nuclear ribonucleoprotein polypeptide B -3.0833
NXT1 nuclear transport factor 2-like export factor 1 -2.9951
TOR1A torsin family 1, member A (torsin A) -2.85593
GTPBP8 GTP-binding protein 8 (putative) -2.7652
IL21 interleukin 21 -2.7534
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.7367
FEN1 flap structure-specific endonuclease 1 -2.7166
ADRB2 adrenoceptor beta 2, surface -2.6945
SNX5 sorting nexin 5 -2.61535
NUP88 nucleoporin 88kDa -2.60818
PCDHB3 protocadherin beta 3 -2.58965
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.55165
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 -2.5376
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.5256
BASP1 brain abundant, membrane attached signal protein 1 -2.4857
RIN2 Ras and Rab interactor 2 -2.48315
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.4775
MAP2K4 mitogen-activated protein kinase kinase 4 -2.47493
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.47465
RPA3 replication protein A3, 14kDa -2.4354
STMN1 stathmin 1 -2.4307
MCM3 minichromosome maintenance complex component 3 -2.42285
GRWD1 glutamate-rich WD repeat containing 1 -2.3857
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -2.3757
HDAC2 histone deacetylase 2 -2.36445
NOP2 NOP2 nucleolar protein -2.3487
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.3303
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.3071
C1QA complement component 1, q subcomponent, A chain -2.2917
FLNC filamin C, gamma -2.2898
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.25575
ZWINT ZW10 interacting kinetochore protein -2.25235
TOR4A torsin family 4, member A -2.2357
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.23385
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.2279
MYL4 myosin, light chain 4, alkali; atrial, embryonic -2.22602
FCGBP Fc fragment of IgG binding protein -2.2221
STAB1 stabilin 1 -2.21548
ENOPH1 enolase-phosphatase 1 -2.2149
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -2.2032
CAAP1 caspase activity and apoptosis inhibitor 1 -2.20255
CORO1A coronin, actin binding protein, 1A -2.1978
AK8 adenylate kinase 8 -2.1963
GJD2 gap junction protein, delta 2, 36kDa -2.16155
AQP2 aquaporin 2 (collecting duct) -2.16125
DCTN5 dynactin 5 (p25) -2.15945
BARX2 BARX homeobox 2 -2.1594
SLN sarcolipin -2.14885
TYMS thymidylate synthetase -2.14435
H2AX H2A.X variant histone -2.14025
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.1396
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.1392
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.1338
C1QB complement component 1, q subcomponent, B chain -2.13025
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -2.12107
NAP1L4 nucleosome assembly protein 1-like 4 -2.11775
ERN1 endoplasmic reticulum to nucleus signaling 1 -2.0996
TMEM123 transmembrane protein 123 -2.0992
MRPL35 mitochondrial ribosomal protein L35 -2.09685
RBBP9 retinoblastoma binding protein 9 -2.08425
STOML2 stomatin (EPB72)-like 2 -2.06125
NLRP2B NLR family pyrin domain containing 2B -2.058
CTCF CCCTC-binding factor (zinc finger protein) -2.0508
RAP1A RAP1A, member of RAS oncogene family -2.04735
LGI2 leucine-rich repeat LGI family, member 2 -2.04105
MXRA5 matrix-remodelling associated 5 -2.03395
GADD45B growth arrest and DNA-damage-inducible, beta -2.03222
COMMD10 COMM domain containing 10 -2.03135
TMEM230 transmembrane protein 230 -2.02865
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.02695
LOX lysyl oxidase -2.01982
MBTPS2 membrane-bound transcription factor peptidase, site 2 -2.01872
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.0183
STATH statherin -2.01335
MCM5 minichromosome maintenance complex component 5 -2.01297
TMEM126B transmembrane protein 126B -2.0112
FANCG Fanconi anemia, complementation group G -2.00805