CRCGN015_MCF10A.TP53.M_24H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 11.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

152 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.4899
SPAG4 sperm associated antigen 4 5.20265
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.0925
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.02255
AGR2 anterior gradient 2 5.0
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.79435
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.7742
UBQLN2 ubiquilin 2 4.75695
E2F2 E2F transcription factor 2 4.66275
CCP110 centriolar coiled coil protein 110kDa 4.6292
TCTN1 tectonic family member 1 4.52565
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.34425
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.71015
KLHL9 kelch-like family member 9 3.67007
ZDHHC11B zinc finger, DHHC-type containing 11B 3.41995
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.3456
REG1A regenerating islet-derived 1 alpha 3.3128
REG3A regenerating islet-derived 3 alpha 2.9158
TPD52L2 tumor protein D52-like 2 2.85225
ENOSF1 enolase superfamily member 1 2.75984
TM4SF20 transmembrane 4 L six family member 20 2.5623
MELK maternal embryonic leucine zipper kinase 2.5277
EVI2B ecotropic viral integration site 2B 2.518
DOK4 docking protein 4 2.49767
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 2.49205
VPS35L VPS35 endosomal protein sorting factor like 2.48725
SIL1 SIL1 nucleotide exchange factor 2.4302
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.4297
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.42095
FAM13A family with sequence similarity 13, member A 2.40305
SPX spexin hormone 2.36675
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.3529
CAMLG calcium modulating ligand 2.34655
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.3439
HOXC6 homeobox C6 2.3437
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.34285
HOXA3 homeobox A3 2.342
BMP8B bone morphogenetic protein 8b 2.3388
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.33323
SPA17 sperm autoantigenic protein 17 2.3326
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.32935
BCORL1 BCL6 corepressor-like 1 2.31335
DLX2 distal-less homeobox 2 2.29128
BMP3 bone morphogenetic protein 3 2.2892
EVI2A ecotropic viral integration site 2A 2.26265
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.25665
SPATA7 spermatogenesis associated 7 2.24985
RHOBTB1 Rho-related BTB domain containing 1 2.24795
SP3 Sp3 transcription factor 2.24115
TPPP tubulin polymerization promoting protein 2.23555
GDE1 glycerophosphodiester phosphodiesterase 1 2.20675
HOXC8 homeobox C8 2.2065
TPPP3 tubulin polymerization-promoting protein family member 3 2.19115
ST18 suppression of tumorigenicity 18, zinc finger 2.19045
KRABD4 KRAB domain containing 4 2.18315
ASPA aspartoacylase 2.18205
PCDHB13 protocadherin beta 13 2.181
TCAP titin-cap 2.17855
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.1781
KIF3A kinesin family member 3A 2.1769
GSDME gasdermin E 2.16945
CATSPERZ catsper channel auxiliary subunit zeta 2.16715
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 2.152
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.1504
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.14735
TRIM66 tripartite motif containing 66 2.143
ZC2HC1C zinc finger, C2HC-type containing 1C 2.1333
ACBD3 acyl-CoA binding domain containing 3 2.12385
EID1 EP300 interacting inhibitor of differentiation 1 2.12213
TSPAN12 tetraspanin 12 2.1155
MNS1 meiosis-specific nuclear structural 1 2.11415
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.1111
MUC3B mucin 3B, cell surface associated 2.10358
SPAG16 sperm associated antigen 16 2.10265
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.102
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.0971
ELMO3 engulfment and cell motility 3 2.09305
FOXJ1 forkhead box J1 2.0894
CEPT1 choline/ethanolamine phosphotransferase 1 2.08415
LYRM1 LYR motif containing 1 2.08255
ZBTB20 zinc finger and BTB domain containing 20 2.07687
TUBA4B tubulin, alpha 4b 2.0754
MTUS1 microtubule associated tumor suppressor 1 2.06922
MUC13 mucin 13, cell surface associated 2.06715
DPEP1 dipeptidase 1 (renal) 2.06155
TMEM135 transmembrane protein 135 2.0586
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.0584
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.0571
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.0552
CD70 CD70 molecule 2.04935
DNAH17 dynein, axonemal, heavy chain 17 2.0456
CNRIP1 cannabinoid receptor interacting protein 1 2.042
IFNAR2 interferon (alpha, beta and omega) receptor 2 2.0357
KIFC3 kinesin family member C3 2.021
DOK2 docking protein 2, 56kDa 2.0141
ZBP1 Z-DNA binding protein 1 2.0112
HS1BP3 HCLS1 binding protein 3 2.01115
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.00375

decreased expression

Symbol Name Standardized Value
GRWD1 glutamate-rich WD repeat containing 1 -4.97255
KRT14 keratin 14, type I -4.9521
HEATR1 HEAT repeat containing 1 -4.92777
CDC45 cell division cycle 45 -4.90255
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.61525
SCYL3 SCY1-like 3 (S. cerevisiae) -4.58822
TMEM43 transmembrane protein 43 -3.2207
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.16453
NT5DC2 5'-nucleotidase domain containing 2 -3.08495
ACAA1 acetyl-CoA acyltransferase 1 -2.9583
KRT6A keratin 6A, type II -2.8707
REXO2 RNA exonuclease 2 -2.869
KRT5 keratin 5, type II -2.8512
KRT6B keratin 6B, type II -2.6847
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.60865
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.60075
SPRR3 small proline-rich protein 3 -2.56545
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.54885
AGMAT agmatine ureohydrolase (agmatinase) -2.52595
VMP1 vacuole membrane protein 1 -2.52405
MPZL2 myelin protein zero-like 2 -2.52093
AHSG alpha-2-HS-glycoprotein -2.49323
APOA2 apolipoprotein A-II -2.46555
SPRR1B small proline-rich protein 1B -2.45355
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.431
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.37785
S100A2 S100 calcium binding protein A2 -2.3702
SPINK5 serine peptidase inhibitor, Kazal type 5 -2.3507
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -2.33325
SCAP SREBF chaperone -2.3305
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.3134
NOP16 NOP16 nucleolar protein -2.29247
TYR tyrosinase -2.27275
PI3 peptidase inhibitor 3, skin-derived -2.27128
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.25735
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -2.23053
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.2077
FAM107A family with sequence similarity 107, member A -2.1857
CTPS1 CTP synthase 1 -2.17815
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.1636
CD320 CD320 molecule -2.1319
TTC4 tetratricopeptide repeat domain 4 -2.12205
LYPD3 LY6/PLAUR domain containing 3 -2.11745
ORM1 orosomucoid 1 -2.11595
NDP Norrie disease (pseudoglioma) -2.1084
S100A7 S100 calcium binding protein A7 -2.1047
FOSL1 FOS-like antigen 1 -2.09725
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -2.08835
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.06225
DCT dopachrome tautomerase -2.06101
TOMM70 translocase of outer mitochondrial membrane 70 -2.05232
ORM2 orosomucoid 2 -2.04775
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -2.03865
MCM5 minichromosome maintenance complex component 5 -2.0065