CRCGN015_MCF10A.TP53.M_24H:E14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bisphenol-a 33.32 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.4253
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.0977
CXCR4 chemokine (C-X-C motif) receptor 4 4.76053
KIF5C kinesin family member 5C 3.6145
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.866
TLCD3A TLC domain containing 3A 2.7017
GSTZ1 glutathione S-transferase zeta 1 2.689
MCUR1 mitochondrial calcium uniporter regulator 1 2.5773
CCDC85B coiled-coil domain containing 85B 2.5208
PDLIM1 PDZ and LIM domain 1 2.50545
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.45205
CCNA1 cyclin A1 2.29235
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.20195
NDE1 nudE neurodevelopment protein 1 2.1367
SRRD SRR1 domain containing 2.0787
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 2.0552
RFXANK regulatory factor X-associated ankyrin-containing protein 2.0549
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.052
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 2.0496
IER3 immediate early response 3 2.01585

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -5.85135
PCNA proliferating cell nuclear antigen -5.0
LAP3 leucine aminopeptidase 3 -4.76725
HMG20B high mobility group 20B -4.75017
TUBB6 tubulin, beta 6 class V -4.35655
FOS FBJ murine osteosarcoma viral oncogene homolog -4.3254
PCCB propionyl CoA carboxylase, beta polypeptide -3.3084
ANKRD10 ankyrin repeat domain 10 -2.6987
RGS2 regulator of G-protein signaling 2 -2.6291
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -2.61185
SECTM1 secreted and transmembrane 1 -2.59295
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.51205
AUH AU RNA binding protein/enoyl-CoA hydratase -2.40465
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.3077
RPS5 ribosomal protein S5 -2.2845
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.28013
ACAA1 acetyl-CoA acyltransferase 1 -2.23318
SGK1 serum/glucocorticoid regulated kinase 1 -2.21215
PANK2 pantothenate kinase 2 -2.21185
XPC xeroderma pigmentosum, complementation group C -2.15695
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.1504
DYNLT1 dynein, light chain, Tctex-type 1 -2.12695
DUSP14 dual specificity phosphatase 14 -2.1134
TP53BP2 tumor protein p53 binding protein 2 -2.1063
DCPH1 damage control phosphatase 1 -2.08865
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -2.0461
SH3GL3 SH3-domain GRB2-like 3 -2.01
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 -2.0045