CRCGN015_MCF10A.TP53.M_24H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bisphenol-a 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 4.87795
LGMN legumain 4.70875
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.44153
WASF3 WAS protein family, member 3 4.3284
MELK maternal embryonic leucine zipper kinase 3.79995
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 3.78565
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.73544
FKBP14 FK506 binding protein 14, 22 kDa 3.49885
BAX BCL2-associated X protein 3.31428
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.8462
PDLIM1 PDZ and LIM domain 1 2.5989
NUBPL nucleotide binding protein-like 2.5925
WDTC1 WD and tetratricopeptide repeats 1 2.5547
ZNF747 zinc finger protein 747 2.4848
CCDC85B coiled-coil domain containing 85B 2.43525
RSRP1 arginine/serine-rich protein 1 2.43458
KRIT1 KRIT1, ankyrin repeat containing 2.4175
FAM184A family with sequence similarity 184, member A 2.3689
CEP170 centrosomal protein 170kDa 2.34345
RXYLT1 ribitol xylosyltransferase 1 2.30908
ZNF783 zinc finger family member 783 2.30137
DHDDS dehydrodolichyl diphosphate synthase 2.24995
SPAG16 sperm associated antigen 16 2.2366
MRPL19 mitochondrial ribosomal protein L19 2.2212
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 2.21505
SRRD SRR1 domain containing 2.194
SETBP1 SET binding protein 1 2.1741
FBXO31 F-box protein 31 2.155
ATL2 atlastin GTPase 2 2.14815
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.1406
FHL2 four and a half LIM domains 2 2.13075
LARS1 leucyl-tRNA synthetase 1 2.1262
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.1143
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.09068
MARCHF3 membrane associated ring-CH-type finger 3 2.05345
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 2.05242
RAB27A RAB27A, member RAS oncogene family 2.04618
LYPLA2 lysophospholipase II 2.04612
ROPN1B rhophilin associated tail protein 1B 2.03655
ZBTB38 zinc finger and BTB domain containing 38 2.03655
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.0301
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.0238
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.0165
TBC1D31 TBC1 domain family, member 31 2.0135
PADI2 peptidyl arginine deiminase, type II 2.0054
BMP4 bone morphogenetic protein 4 2.0011

decreased expression

Symbol Name Standardized Value
ENOPH1 enolase-phosphatase 1 -5.34205
SGK1 serum/glucocorticoid regulated kinase 1 -4.38245
NUSAP1 nucleolar and spindle associated protein 1 -4.26655
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.72875
PSIP1 PC4 and SFRS1 interacting protein 1 -3.52745
ANKRD10 ankyrin repeat domain 10 -3.46415
BLCAP bladder cancer associated protein -3.1564
STXBP2 syntaxin binding protein 2 -3.0325
TUBA4A tubulin, alpha 4a -2.7634
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.6811
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -2.54155
EMC7 ER membrane protein complex subunit 7 -2.4318
SPINT1 serine peptidase inhibitor, Kunitz type 1 -2.34655
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.30315
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.29195
FBXO21 F-box protein 21 -2.28978
MCOLN1 mucolipin 1 -2.27655
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.2386
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.19075
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.1522
PRCC papillary renal cell carcinoma (translocation-associated) -2.1184
S100A4 S100 calcium binding protein A4 -2.10115
TRIB3 tribbles pseudokinase 3 -2.07985
GFUS GDP-L-fucose synthase -2.07868
PDZK1IP1 PDZK1 interacting protein 1 -2.0719
MDFI MyoD family inhibitor -2.04575
NFE2L1 nuclear factor, erythroid 2-like 1 -2.0102