CRCGN015_MCF10A.TP53.M_24H:E18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 11.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 6.9854
NUCB2 nucleobindin 2 5.2654
PEX11A peroxisomal biogenesis factor 11 alpha 5.2114
FGFR4 fibroblast growth factor receptor 4 4.65452
TXNRD1 thioredoxin reductase 1 4.11725
CAPN1 calpain 1, (mu/I) large subunit 3.65575
SNX11 sorting nexin 11 3.59232
NOTCH1 notch 1 3.16215
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.0733
STATH statherin 2.7848
SMR3B submaxillary gland androgen regulated protein 3B 2.67915
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.56715
PRR15L proline rich 15-like 2.5523
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.4537
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.3986
SMR3A submaxillary gland androgen regulated protein 3A 2.34635
NFE2L1 nuclear factor, erythroid 2-like 1 2.33303
WIF1 WNT inhibitory factor 1 2.2838
GLRX glutaredoxin (thioltransferase) 2.2724
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.25955
NECTIN4 nectin cell adhesion molecule 4 2.23685
CBX1 chromobox homolog 1 2.2044
RAB27B RAB27B, member RAS oncogene family 2.19597
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.17985
SAR1B secretion associated, Ras related GTPase 1B 2.1473
LPO lactoperoxidase 2.10335
APOD apolipoprotein D 2.09385
SQSTM1 sequestosome 1 2.08812
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.07297
PLAAT3 phospholipase A and acyltransferase 3 2.04075
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.0392
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.01097

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -5.9612
TES testin LIM domain protein -5.49222
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.5708
KDM3A lysine (K)-specific demethylase 3A -4.51735
CTNND1 catenin (cadherin-associated protein), delta 1 -3.82187
THAP11 THAP domain containing 11 -3.7324
STMN1 stathmin 1 -3.71375
GRWD1 glutamate-rich WD repeat containing 1 -3.61315
ACAA1 acetyl-CoA acyltransferase 1 -3.09312
IGFBP7 insulin-like growth factor binding protein 7 -2.96877
ITM2C integral membrane protein 2C -2.72575
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.68895
AURKB aurora kinase B -2.56515
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.51917
MTO1 mitochondrial tRNA translation optimization 1 -2.4506
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.4048
FHL2 four and a half LIM domains 2 -2.383
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.34015
RFC2 replication factor C (activator 1) 2, 40kDa -2.33308
PCCB propionyl CoA carboxylase, beta polypeptide -2.28245
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.27645
TMX2 thioredoxin-related transmembrane protein 2 -2.27595
TASP1 taspase, threonine aspartase, 1 -2.26365
CKAP5 cytoskeleton associated protein 5 -2.20155
NCAPH non-SMC condensin I complex, subunit H -2.18495
ZNF574 zinc finger protein 574 -2.1212
CBR3 carbonyl reductase 3 -2.1201
NUP133 nucleoporin 133kDa -2.09315
GTPBP8 GTP-binding protein 8 (putative) -2.09025
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.08695
MOK MOK protein kinase -2.0773
EPHA4 EPH receptor A4 -2.0659
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.04305
STAC SH3 and cysteine rich domain -2.03985
CD244 CD244 molecule, natural killer cell receptor 2B4 -2.02445
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.00355