CRCGN015_MCF10A.TP53.M_24H:E19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n??=-diacetylbenzidine 102.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

295 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 10.0
TBX2 T-box 2 9.29617
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 4.2073
LGMN legumain 3.8563
SPDEF SAM pointed domain containing ETS transcription factor 3.6632
CENPE centromere protein E, 312kDa 3.5775
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.3548
ZMAT3 zinc finger, matrin-type 3 3.2227
GPC1 glypican 1 3.1642
NUBPL nucleotide binding protein-like 3.1496
CCDC102B coiled-coil domain containing 102B 3.1088
EVL Enah/Vasp-like 2.9546
TBPL1 TBP-like 1 2.7895
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.7755
PCYOX1 prenylcysteine oxidase 1 2.7487
SLC16A4 solute carrier family 16, member 4 2.7082
PLS3 plastin 3 2.7082
GPR137B G protein-coupled receptor 137B 2.701
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.6826
LAMB1 laminin, beta 1 2.6761
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.6299
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.6124
POMK protein-O-mannose kinase 2.5978
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.59705
NADSYN1 NAD synthetase 1 2.5833
RAB23 RAB23, member RAS oncogene family 2.5777
FAM168B family with sequence similarity 168, member B 2.5579
HMGA2 high mobility group AT-hook 2 2.5345
MAP6D1 MAP6 domain containing 1 2.5299
TEX10 testis expressed 10 2.5225
APOA2 apolipoprotein A-II 2.522
DBF4 DBF4 zinc finger 2.5
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.484
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.4731
PRKD3 protein kinase D3 2.46835
TGFBI transforming growth factor, beta-induced, 68kDa 2.4471
METTL8 methyltransferase like 8 2.446
NUP155 nucleoporin 155kDa 2.4442
GLOD4 glyoxalase domain containing 4 2.4417
LRRC8E leucine rich repeat containing 8 family, member E 2.4379
TBC1D31 TBC1 domain family, member 31 2.4322
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.4233
LRRC17 leucine rich repeat containing 17 2.4084
MIDEAS mitotic deacetylase associated SANT domain protein 2.4083
TMEM131 transmembrane protein 131 2.4069
ETV6 ets variant 6 2.4056
TFB1M transcription factor B1, mitochondrial 2.3897
TASOR2 transcription activation suppressor family member 2 2.3877
SGSH N-sulfoglucosamine sulfohydrolase 2.34575
FLNB filamin B, beta 2.34395
RPIA ribose 5-phosphate isomerase A 2.3434
CCNT1 cyclin T1 2.3228
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.3225
NUP85 nucleoporin 85kDa 2.3151
TMF1 TATA element modulatory factor 1 2.29355
PGM3 phosphoglucomutase 3 2.2904
ZBTB11 zinc finger and BTB domain containing 11 2.2886
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.2713
SIAH2 siah E3 ubiquitin protein ligase 2 2.2592
TDG thymine-DNA glycosylase 2.256
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.2418
HJURP Holliday junction recognition protein 2.2363
BNC2 basonuclin 2 2.2258
VCAN versican 2.20352
TRIP12 thyroid hormone receptor interactor 12 2.2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 2.1844
ITM2C integral membrane protein 2C 2.1756
ZNF652 zinc finger protein 652 2.1648
CTPS2 CTP synthase 2 2.1578
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.1576
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 2.1574
TFDP1 transcription factor Dp-1 2.15385
PTH1R parathyroid hormone 1 receptor 2.1521
ANO1 anoctamin 1, calcium activated chloride channel 2.1488
GCC2 GRIP and coiled-coil domain containing 2 2.1465
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.1461
TDP1 tyrosyl-DNA phosphodiesterase 1 2.1448
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.1417
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.1402
SEC16A SEC16 homolog A (S. cerevisiae) 2.1381
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.1351
BIRC2 baculoviral IAP repeat containing 2 2.1323
ASPA aspartoacylase 2.132
CAPRIN2 caprin family member 2 2.1278
MEGF8 multiple EGF-like-domains 8 2.1248
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.1187
COL4A1 collagen, type IV, alpha 1 2.1168
ANAPC5 anaphase promoting complex subunit 5 2.11293
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.1026
ADPGK ADP-dependent glucokinase 2.101
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.0998
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.0985
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.0959
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.0934
RANBP2 RAN binding protein 2 2.0892
ACSL1 acyl-CoA synthetase long-chain family member 1 2.07965
JTB jumping translocation breakpoint 2.07887
ZNF551 zinc finger protein 551 2.0761
GDF7 growth differentiation factor 7 2.0686
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.0619
TAOK3 TAO kinase 3 2.0615
CEP83 centrosomal protein 83kDa 2.0576
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 2.055
FAM169A family with sequence similarity 169, member A 2.0521
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.05205
CENPU centromere protein U 2.0353
MAGED1 melanoma antigen family D1 2.0342
HMGN3 high mobility group nucleosomal binding domain 3 2.0324
SMTN smoothelin 2.0321
PTPRM protein tyrosine phosphatase, receptor type, M 2.0294
FBXO5 F-box protein 5 2.0294
FRK fyn-related Src family tyrosine kinase 2.0221
SOSTDC1 sclerostin domain containing 1 2.0133
REV1 REV1, polymerase (DNA directed) 2.0083
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.0083
HOMER1 homer scaffolding protein 1 2.0058
CTSZ cathepsin Z 2.0032
SPINK4 serine peptidase inhibitor, Kazal type 4 2.0022

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -10.0
CD58 CD58 molecule -9.86177
TRAPPC3 trafficking protein particle complex 3 -9.6989
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -8.1369
SORBS3 sorbin and SH3 domain containing 3 -5.443
TUBA4A tubulin, alpha 4a -4.571
MRPS15 mitochondrial ribosomal protein S15 -4.5487
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -3.7116
MAT2B methionine adenosyltransferase II, beta -3.6101
MEAF6 MYST/Esa1-associated factor 6 -3.354
FAIM Fas apoptotic inhibitory molecule -3.29
COL8A2 collagen, type VIII, alpha 2 -3.26885
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -3.2323
TSHZ2 teashirt zinc finger homeobox 2 -3.1833
TMEM209 transmembrane protein 209 -3.1577
H2BC5 H2B clustered histone 5 -3.0891
TMEM35B transmembrane protein 35B -3.0884
CLASRP CLK4-associating serine/arginine rich protein -3.0576
FAM13B family with sequence similarity 13, member B -3.0343
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -3.0089
MRPS31 mitochondrial ribosomal protein S31 -2.99745
QTRT1 queuine tRNA-ribosyltransferase 1 -2.9895
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 -2.9892
GOLPH3L golgi phosphoprotein 3-like -2.9587
MAP7D1 MAP7 domain containing 1 -2.904
PFN1 profilin 1 -2.8976
WDR70 WD repeat domain 70 -2.8946
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.8424
PDIA3 protein disulfide isomerase family A, member 3 -2.778
ZNF768 zinc finger protein 768 -2.767
CDX2 caudal type homeobox 2 -2.7024
MRPL37 mitochondrial ribosomal protein L37 -2.6973
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.6952
SAP30L SAP30-like -2.6865
ACP2 acid phosphatase 2, lysosomal -2.6761
SDF2L1 stromal cell-derived factor 2-like 1 -2.6444
TRIM39-RPP21 TRIM39-RPP21 readthrough -2.6292
ZNF217 zinc finger protein 217 -2.6102
NTHL1 nth endonuclease III-like 1 (E. coli) -2.6017
ZMYM4 zinc finger, MYM-type 4 -2.58407
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.5756
DGAT1 diacylglycerol O-acyltransferase 1 -2.5691
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.55765
HIRIP3 HIRA interacting protein 3 -2.5483
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -2.5338
PRPF19 pre-mRNA processing factor 19 -2.5191
ZMYM1 zinc finger, MYM-type 1 -2.5158
GATAD2A GATA zinc finger domain containing 2A -2.5092
BTNL3 butyrophilin-like 3 -2.5032
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -2.4966
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 -2.493
WBP4 WW domain binding protein 4 -2.4921
ZCCHC2 zinc finger, CCHC domain containing 2 -2.4911
NDE1 nudE neurodevelopment protein 1 -2.4845
ILK integrin-linked kinase -2.4826
AGO1 argonaute RISC catalytic component 1 -2.4821
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.4742
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.4703
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.4637
ZMYM6 zinc finger, MYM-type 6 -2.4604
DPYD dihydropyrimidine dehydrogenase -2.4517
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -2.451
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.4441
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -2.4381
PARM1 prostate androgen-regulated mucin-like protein 1 -2.4375
KCTD9 potassium channel tetramerization domain containing 9 -2.4284
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.4191
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.4176
INTS9 integrator complex subunit 9 -2.4109
ADAT1 adenosine deaminase, tRNA-specific 1 -2.4085
CAPN10 calpain 10 -2.3754
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.3699
ECEL1 endothelin converting enzyme-like 1 -2.3662
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.366
MED7 mediator complex subunit 7 -2.3654
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.3641
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.36405
ELF2 E74-like factor 2 (ets domain transcription factor) -2.3621
MGA MGA, MAX dimerization protein -2.3602
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.3588
N4BP2L1 NEDD4 binding protein 2-like 1 -2.35607
TEX11 testis expressed 11 -2.3531
TAGLN2 transgelin 2 -2.33865
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -2.3351
CHMP7 charged multivesicular body protein 7 -2.3341
KRT33A keratin 33A, type I -2.3326
STIP1 stress-induced phosphoprotein 1 -2.33165
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.3298
KLHL26 kelch-like family member 26 -2.3098
CDK5 cyclin-dependent kinase 5 -2.3076
TTC1 tetratricopeptide repeat domain 1 -2.2985
AIRIM AFG2 interacting ribosome maturation factor -2.2963
UBXN2B UBX domain protein 2B -2.2915
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.2897
FUBP3 far upstream element (FUSE) binding protein 3 -2.2768
MAX MYC associated factor X -2.27668
SPIN2B spindlin family, member 2B -2.2735
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.2725
MEF2B myocyte enhancer factor 2B -2.2725
NAV2 neuron navigator 2 -2.2708
TTC33 tetratricopeptide repeat domain 33 -2.27
STX17 syntaxin 17 -2.2636
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -2.23825
ZCCHC10 zinc finger, CCHC domain containing 10 -2.2348
STXBP3 syntaxin binding protein 3 -2.2333
SNX2 sorting nexin 2 -2.2305
TBKBP1 TBK1 binding protein 1 -2.2258
AZIN2 antizyme inhibitor 2 -2.2218
SAP30 Sin3A-associated protein, 30kDa -2.2181
CCND3 cyclin D3 -2.2159
TIPRL TOR signaling pathway regulator -2.214
NXPE4 neurexophilin and PC-esterase domain family, member 4 -2.2136
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.2117
PARD6A par-6 family cell polarity regulator alpha -2.2046
KLK1 kallikrein 1 -2.2016
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.1933
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.1917
RTN3 reticulon 3 -2.1905
CENPS-CORT CENPS-CORT readthrough -2.1842
PRDM1 PR domain containing 1, with ZNF domain -2.176
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.17475
ZXDC ZXD family zinc finger C -2.1681
PDLIM2 PDZ and LIM domain 2 (mystique) -2.1663
JCHAIN joining chain of multimeric IgA and IgM -2.1632
STK32B serine/threonine kinase 32B -2.16
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.1591
RAD21 RAD21 homolog (S. pombe) -2.1497
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -2.1465
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.1459
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -2.1359
CHMP5 charged multivesicular body protein 5 -2.13325
LOC102724594 splicing factor U2AF 35 kDa subunit -2.1205
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.1173
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.1152
MORC3 MORC family CW-type zinc finger 3 -2.1103
CNOT7 CCR4-NOT transcription complex, subunit 7 -2.1099
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) -2.1094
GIMAP4 GTPase, IMAP family member 4 -2.1081
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.1078
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.0975
ZNF219 zinc finger protein 219 -2.0919
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.0901
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.0881
SIK2 salt-inducible kinase 2 -2.0876
GPATCH3 G patch domain containing 3 -2.0875
PNKP polynucleotide kinase 3'-phosphatase -2.0775
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.0762
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.0761
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.0735
H2AC7 H2A clustered histone 7 -2.0729
CCNDBP1 cyclin D-type binding-protein 1 -2.0717
RABL3 RAB, member of RAS oncogene family-like 3 -2.0618
TCL1B T-cell leukemia/lymphoma 1B -2.0609
ICE2 interactor of little elongation complex ELL subunit 2 -2.0608
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.0594
CMTR1 cap methyltransferase 1 -2.0573
ARRB2 arrestin, beta 2 -2.0569
CCDC47 coiled-coil domain containing 47 -2.0558
KRT31 keratin 31, type I -2.0536
ERH enhancer of rudimentary homolog (Drosophila) -2.053
KLHL12 kelch-like family member 12 -2.0489
WFS1 Wolfram syndrome 1 (wolframin) -2.048
ARSA arylsulfatase A -2.0456
CP ceruloplasmin (ferroxidase) -2.0412
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.0385
H2AC19 H2A clustered histone 19 -2.0351
PRSS21 protease, serine, 21 (testisin) -2.0332
KCTD17 potassium channel tetramerization domain containing 17 -2.0303
FNDC8 fibronectin type III domain containing 8 -2.0283
CTC1 CTS telomere maintenance complex component 1 -2.0142
RPAP1 RNA polymerase II associated protein 1 -2.0121
AGO3 argonaute RISC catalytic component 3 -2.01035
OCA2 oculocutaneous albinism II -2.0081
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 -2.0077
INPP5B inositol polyphosphate-5-phosphatase, 75kDa -2.00655
RBM22 RNA binding motif protein 22 -2.0026
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.0019