CRCGN015_MCF10A.TP53.M_24H:E20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n??=-diacetylbenzidine 34.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BTK Bruton agammaglobulinemia tyrosine kinase 5.28585
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.12345
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.07708
STXBP1 syntaxin binding protein 1 3.95075
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.77085
KIF5C kinesin family member 5C 3.71065
GRB10 growth factor receptor-bound protein 10 3.29598
SMIM40 small integral membrane protein 40 3.1571
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.08973
BLMH bleomycin hydrolase 2.82075
RFWD3 ring finger and WD repeat domain 3 2.7536
HMGA2 high mobility group AT-hook 2 2.69325
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.42938
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.3209
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.3044
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.3021
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.29925
WIF1 WNT inhibitory factor 1 2.2785
CDCA4 cell division cycle associated 4 2.27355
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.1845
ESRP2 epithelial splicing regulatory protein 2 2.16835
KIFC1 kinesin family member C1 2.162
HBEGF heparin-binding EGF-like growth factor 2.15645
DENND2D DENN/MADD domain containing 2D 2.1011
GSTZ1 glutathione S-transferase zeta 1 2.0954
CTBS chitobiase, di-N-acetyl- 2.08827
PHF10 PHD finger protein 10 2.083
TRAM2 translocation associated membrane protein 2 2.07998
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.0461
GRB7 growth factor receptor-bound protein 7 2.04545
MAPK12 mitogen-activated protein kinase 12 2.04245
HROB homologous recombination factor with OB-fold 2.0065

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -5.74545
MRPS2 mitochondrial ribosomal protein S2 -5.7234
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.91495
BLCAP bladder cancer associated protein -4.7173
CAB39 calcium binding protein 39 -4.2864
CPNE3 copine III -4.0565
BID BH3 interacting domain death agonist -3.97202
HSPB1 heat shock 27kDa protein 1 -3.94235
RBM42 RNA binding motif protein 42 -3.39115
CD81 CD81 molecule -3.3773
CRTAP cartilage associated protein -2.87555
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.7553
RAB5IF RAB5 interacting factor -2.7498
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.65545
TRIB3 tribbles pseudokinase 3 -2.63225
SEC16A SEC16 homolog A (S. cerevisiae) -2.61985
TMEM147 transmembrane protein 147 -2.56515
ZNF302 zinc finger protein 302 -2.5548
TPD52L1 tumor protein D52-like 1 -2.5403
TSC1 tuberous sclerosis 1 -2.51035
PMPCA peptidase (mitochondrial processing) alpha -2.4861
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.4751
CBR1 carbonyl reductase 1 -2.44615
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.34745
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.3426
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.30872
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.30055
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.28955
DCPH1 damage control phosphatase 1 -2.2709
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.26045
COQ4 coenzyme Q4 -2.25365
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.2496
GPATCH1 G patch domain containing 1 -2.24445
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.24275
PIERCE1 piercer of microtubule wall 1 -2.24105
LIN37 lin-37 DREAM MuvB core complex component -2.2244
CCDC170 coiled-coil domain containing 170 -2.2227
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.2046
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.1972
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -2.19668
NELFB negative elongation factor complex member B -2.185
AACS acetoacetyl-CoA synthetase -2.18445
CAPNS1 calpain, small subunit 1 -2.18205
STAP2 signal transducing adaptor family member 2 -2.1762
RGS2 regulator of G-protein signaling 2 -2.15235
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.1244
SCARB1 scavenger receptor class B, member 1 -2.11985
CDH4 cadherin 4, type 1, R-cadherin (retinal) -2.11167
SPACA9 sperm acrosome associated 9 -2.1109
PSENEN presenilin enhancer gamma secretase subunit -2.081
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.04715
FAIM Fas apoptotic inhibitory molecule -2.04385
MSRB1 methionine sulfoxide reductase B1 -2.03415
PRCP prolylcarboxypeptidase (angiotensinase C) -2.0255
QPRT quinolinate phosphoribosyltransferase -2.0236
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -2.02117
HSPA1A heat shock 70kDa protein 1A -2.00135