CRCGN015_MCF10A.TP53.M_24H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 100.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

94 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.40487
SPAG4 sperm associated antigen 4 5.1051
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.9341
IDE insulin-degrading enzyme 4.5705
CISD1 CDGSH iron sulfur domain 1 3.8938
FBXO21 F-box protein 21 3.6424
TPD52L2 tumor protein D52-like 2 3.4702
TBC1D31 TBC1 domain family, member 31 3.05335
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.0381
ENOPH1 enolase-phosphatase 1 2.92905
NUCB2 nucleobindin 2 2.8245
STMN2 stathmin 2 2.7007
SYN1 synapsin I 2.6722
SYT1 synaptotagmin I 2.65268
IL1B interleukin 1, beta 2.52003
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.51145
HHIPL2 HHIP-like 2 2.48495
LCE2B late cornified envelope 2B 2.45285
KRT2 keratin 2, type II 2.3869
WIF1 WNT inhibitory factor 1 2.3336
CENPE centromere protein E, 312kDa 2.2865
TLCD3A TLC domain containing 3A 2.2454
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.21655
RPH3A rabphilin 3A 2.1977
TXNRD1 thioredoxin reductase 1 2.1928
FBXO5 F-box protein 5 2.17135
APLP1 amyloid beta (A4) precursor-like protein 1 2.16105
TAGLN3 transgelin 3 2.13635
NELL2 NEL-like 2 (chicken) 2.13235
SCAMP5 secretory carrier membrane protein 5 2.10185
ZNF532 zinc finger protein 532 2.0908
IQSEC3 IQ motif and Sec7 domain 3 2.0748
NFASC neurofascin 2.07333
GDAP1 ganglioside induced differentiation associated protein 1 2.06475
GRB7 growth factor receptor-bound protein 7 2.05885
GYG2 glycogenin 2 2.0419
AGO2 argonaute RISC catalytic component 2 2.0396
ACTG2 actin, gamma 2, smooth muscle, enteric 2.02315
VSNL1 visinin-like 1 2.01577
RIC3 RIC3 acetylcholine receptor chaperone 2.01525
FLG filaggrin 2.0113
GRM2 glutamate receptor, metabotropic 2 2.0032

decreased expression

Symbol Name Standardized Value
CHIC2 cysteine-rich hydrophobic domain 2 -5.22135
HAT1 histone acetyltransferase 1 -5.16325
TRAPPC3 trafficking protein particle complex 3 -5.02752
GRN granulin -4.84717
HMG20B high mobility group 20B -4.43143
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.6984
TOR1A torsin family 1, member A (torsin A) -3.6461
LYPLA1 lysophospholipase I -3.5955
RGS2 regulator of G-protein signaling 2 -3.4257
HSPA1A heat shock 70kDa protein 1A -3.271
ADRB2 adrenoceptor beta 2, surface -3.1638
SNX6 sorting nexin 6 -3.0337
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.78395
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.72295
ILK integrin-linked kinase -2.6352
ARHGAP10 Rho GTPase activating protein 10 -2.6119
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.5969
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.53795
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.53395
S100PBP S100P binding protein -2.4971
KPTN kaptin (actin binding protein) -2.46045
DDIT4 DNA-damage-inducible transcript 4 -2.45505
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.4523
GRWD1 glutamate-rich WD repeat containing 1 -2.41665
PEF1 penta-EF-hand domain containing 1 -2.3964
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.3931
LDHD lactate dehydrogenase D -2.37295
MSMO1 methylsterol monooxygenase 1 -2.32365
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.3133
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.28335
MRPS33 mitochondrial ribosomal protein S33 -2.28215
EXOC1 exocyst complex component 1 -2.2722
OXCT1 3-oxoacid CoA transferase 1 -2.2603
YTHDC1 YTH domain containing 1 -2.2591
GMFG glia maturation factor, gamma -2.2564
COA3 cytochrome c oxidase assembly factor 3 -2.2181
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.20765
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.15158
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.1486
VAMP8 vesicle-associated membrane protein 8 -2.1363
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.1302
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.12485
TSC22D3 TSC22 domain family, member 3 -2.11092
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.10105
RPA3 replication protein A3, 14kDa -2.09825
TDRD7 tudor domain containing 7 -2.09415
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.09335
GADD45B growth arrest and DNA-damage-inducible, beta -2.09077
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.0891
PINK1 PTEN induced putative kinase 1 -2.0701
CMTR1 cap methyltransferase 1 -2.01765
EXOSC10 exosome component 10 -2.008