CRCGN015_MCF10A.TP53.M_24H:E23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 33.36 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

48 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIF5C kinesin family member 5C 3.73885
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.57425
NCK2 NCK adaptor protein 2 3.3526
CERK ceramide kinase 3.32825
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.58052
AGO2 argonaute RISC catalytic component 2 2.46125
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.43525
CCNA1 cyclin A1 2.3511
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.29095
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.19335
SFXN1 sideroflexin 1 2.14065
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.11895
RAB8A RAB8A, member RAS oncogene family 2.049
CPA4 carboxypeptidase A4 2.04165

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.2138
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.76385
TRAPPC3 trafficking protein particle complex 3 -4.57765
RPS5 ribosomal protein S5 -4.32285
CAB39 calcium binding protein 39 -4.29325
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.2825
GADD45B growth arrest and DNA-damage-inducible, beta -4.26525
COG4 component of oligomeric golgi complex 4 -3.6187
FPGS folylpolyglutamate synthase -3.482
RPA3 replication protein A3, 14kDa -3.4162
RGS2 regulator of G-protein signaling 2 -3.3651
MRPS15 mitochondrial ribosomal protein S15 -2.94065
HSPA1A heat shock 70kDa protein 1A -2.6124
WASHC3 WASH complex subunit 3 -2.4114
RPL27A ribosomal protein L27a -2.2717
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.2574
RPLP2 ribosomal protein, large, P2 -2.25495
NGRN neugrin, neurite outgrowth associated -2.23975
STK16 serine/threonine kinase 16 -2.18045
RPS11 ribosomal protein S11 -2.13595
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -2.1266
RNF146 ring finger protein 146 -2.1188
RPL19 ribosomal protein L19 -2.1094
RPL18A ribosomal protein L18a -2.10155
RPS27 ribosomal protein S27 -2.0944
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.0672
RLF rearranged L-myc fusion -2.0655
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.05915
CZIB CXXC motif containing zinc binding protein -2.05375
RPS7 ribosomal protein S7 -2.02558
ATRAID all-trans retinoic acid-induced differentiation factor -2.0174
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.01595
OVGP1 oviductal glycoprotein 1, 120kDa -2.01295
RPL34 ribosomal protein L34 -2.0097