CRCGN015_MCF10A.TP53.M_24H:E24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 11.12 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

211 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:E24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.30555
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.93075
STAP2 signal transducing adaptor family member 2 4.72905
HAUS3 HAUS augmin-like complex, subunit 3 3.82675
ZNF589 zinc finger protein 589 3.31148
ZNF134 zinc finger protein 134 3.2201
ZNF587B zinc finger protein 587B 3.14645
GAGE8 G antigen 8 3.10245
CSAG2 CSAG family, member 2 3.0982
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.89065
CORO1A coronin, actin binding protein, 1A 2.7933
AIDA axin interactor, dorsalization associated 2.76645
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.7426
CTSZ cathepsin Z 2.60335
MAGEA12 melanoma antigen family A12 2.5976
ZNF532 zinc finger protein 532 2.56945
PRPF3 pre-mRNA processing factor 3 2.5628
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.53815
NOL11 nucleolar protein 11 2.47775
GATAD2A GATA zinc finger domain containing 2A 2.43725
RAD51AP1 RAD51 associated protein 1 2.40985
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 2.40607
FGD6 FYVE, RhoGEF and PH domain containing 6 2.39445
XDH xanthine dehydrogenase 2.38085
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.37395
MYO19 myosin XIX 2.3586
CLCN2 chloride channel, voltage-sensitive 2 2.3367
ZNF671 zinc finger protein 671 2.33015
SPON2 spondin 2, extracellular matrix protein 2.3301
PLPP6 phospholipid phosphatase 6 2.3121
PMM2 phosphomannomutase 2 2.25195
SMIM44 small integral membrane protein 44 2.2367
AGK acylglycerol kinase 2.21343
TPP2 tripeptidyl peptidase II 2.20295
PEX26 peroxisomal biogenesis factor 26 2.18895
PNPLA4 patatin-like phospholipase domain containing 4 2.18825
POGLUT2 protein O-glucosyltransferase 2 2.1754
ZNF197 zinc finger protein 197 2.1707
ZNF266 zinc finger protein 266 2.1445
ZNF329 zinc finger protein 329 2.1351
PRKACB protein kinase, cAMP-dependent, catalytic, beta 2.13487
POM121C POM121 transmembrane nucleoporin C 2.13208
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.12645
DKC1 dyskeratosis congenita 1, dyskerin 2.1237
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal 2.11879
CCL15 chemokine (C-C motif) ligand 15 2.1111
WASF1 WAS protein family, member 1 2.09575
GRB7 growth factor receptor-bound protein 7 2.0934
ELF2 E74-like factor 2 (ets domain transcription factor) 2.08593
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.08525
SH2B3 SH2B adaptor protein 3 2.0699
PRDM5 PR domain containing 5 2.0666
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 2.0529
DAZAP1 DAZ associated protein 1 2.0467
ZNF195 zinc finger protein 195 2.04665
EVL Enah/Vasp-like 2.0402
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.0382
PUDP pseudouridine 5'-phosphatase 2.0378
CEP72 centrosomal protein 72kDa 2.0363
FNBP1L formin binding protein 1-like 2.03495
MAGEA2B melanoma antigen family A2B 2.03395
SPC25 SPC25, NDC80 kinetochore complex component 2.0337
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.03105
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.0289
BNC2 basonuclin 2 2.0246
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.0153
NES nestin 2.01445
ALK anaplastic lymphoma receptor tyrosine kinase 2.01213
KIRREL1 kirre like nephrin family adhesion molecule 1 2.01125
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.001

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -5.48145
TNIP1 TNFAIP3 interacting protein 1 -5.40745
GADD45B growth arrest and DNA-damage-inducible, beta -4.80155
PCNA proliferating cell nuclear antigen -4.66275
DIPK1A divergent protein kinase domain 1A -4.59762
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.56345
COG2 component of oligomeric golgi complex 2 -4.42285
HAT1 histone acetyltransferase 1 -4.2909
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.2429
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -4.08015
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.0075
COG7 component of oligomeric golgi complex 7 -3.98445
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.92035
GOLT1B golgi transport 1B -3.8902
TCTA T-cell leukemia translocation altered -3.71625
RND1 Rho family GTPase 1 -3.49125
IL10RB interleukin 10 receptor, beta -3.48405
DDRGK1 DDRGK domain containing 1 -3.41935
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -3.35975
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -3.2788
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.1656
KRT14 keratin 14, type I -3.1276
CPPED1 calcineurin-like phosphoesterase domain containing 1 -3.1214
MPHOSPH8 M-phase phosphoprotein 8 -3.1144
AKIRIN1 akirin 1 -3.02965
BFAR bifunctional apoptosis regulator -3.0295
MLEC malectin -3.0173
HSPA1A heat shock 70kDa protein 1A -2.9659
RGS2 regulator of G-protein signaling 2 -2.96465
NUBPL nucleotide binding protein-like -2.8632
NABP2 nucleic acid binding protein 2 -2.84965
THAP11 THAP domain containing 11 -2.80365
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.7555
IGFBP7 insulin-like growth factor binding protein 7 -2.74343
CCDC69 coiled-coil domain containing 69 -2.7391
MAGT1 magnesium transporter 1 -2.73685
PHACTR4 phosphatase and actin regulator 4 -2.72295
FBXO21 F-box protein 21 -2.71785
MCM6 minichromosome maintenance complex component 6 -2.66405
REXO2 RNA exonuclease 2 -2.66259
UBOX5 U-box domain containing 5 -2.6114
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.60925
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.60752
ABHD18 abhydrolase domain containing 18 -2.58875
SUGCT succinyl-CoA:glutarate-CoA transferase -2.5853
LBHD1 LBH domain containing 1 -2.55825
LCAT lecithin-cholesterol acyltransferase -2.55675
NT5C2 5'-nucleotidase, cytosolic II -2.54235
RFC2 replication factor C (activator 1) 2, 40kDa -2.53682
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.50045
VCAN versican -2.49636
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.4769
ACAA1 acetyl-CoA acyltransferase 1 -2.47653
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.4672
GADD45G growth arrest and DNA-damage-inducible, gamma -2.46155
ATG9A autophagy related 9A -2.4456
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.4455
H2AC25 H2A clustered histone 25 -2.44035
UNKL unkempt family zinc finger-like -2.4312
HLA-A major histocompatibility complex, class I, A -2.42305
HAGH hydroxyacylglutathione hydrolase -2.3501
RIOK3 RIO kinase 3 -2.34377
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.33938
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.3273
CRYGD crystallin, gamma D -2.32105
NNT nicotinamide nucleotide transhydrogenase -2.29642
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.2963
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.2921
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.291
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.28755
HLA-B major histocompatibility complex, class I, B -2.28553
METTL8 methyltransferase like 8 -2.28395
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.2801
KRIT1 KRIT1, ankyrin repeat containing -2.27568
S100A7 S100 calcium binding protein A7 -2.27425
GCN1 GCN1 activator of EIF2AK4 -2.27173
PLPBP pyridoxal phosphate binding protein -2.27147
RNF170 ring finger protein 170 -2.26955
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.2679
HLA-E major histocompatibility complex, class I, E -2.2654
RSL1D1 ribosomal L1 domain containing 1 -2.26335
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -2.25272
FOXO4 forkhead box O4 -2.23665
LYRM4 LYR motif containing 4 -2.2366
SLC38A12 solute carrier family 38 member 12 -2.2333
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -2.2323
EIF3I eukaryotic translation initiation factor 3, subunit I -2.2202
SYT17 synaptotagmin XVII -2.21445
HOPX HOP homeobox -2.21005
P3H1 prolyl 3-hydroxylase 1 -2.208
COQ9 coenzyme Q9 -2.20125
PEF1 penta-EF-hand domain containing 1 -2.1997
LOC124900388 uncharacterized LOC124900388 -2.19955
TRIM16 tripartite motif containing 16 -2.1927
ISCU iron-sulfur cluster assembly enzyme -2.186
F2R coagulation factor II (thrombin) receptor -2.18545
PPID peptidylprolyl isomerase D -2.17743
HLA-C major histocompatibility complex, class I, C -2.17575
ABAT 4-aminobutyrate aminotransferase -2.17303
TSNAX translin-associated factor X -2.1718
PIH1D1 PIH1 domain containing 1 -2.1684
ZMAT3 zinc finger, matrin-type 3 -2.16695
MAGEH1 melanoma antigen family H1 -2.1661
YAF2 YY1 associated factor 2 -2.15445
KIAA0319L KIAA0319-like -2.15045
MEGF8 multiple EGF-like-domains 8 -2.1486
KRT16 keratin 16, type I -2.1472
NSFL1C NSFL1 (p97) cofactor (p47) -2.14453
NMRK1 nicotinamide riboside kinase 1 -2.1439
TMEM230 transmembrane protein 230 -2.1363
GAA glucosidase, alpha; acid -2.1294
PMVK phosphomevalonate kinase -2.12705
TSPAN31 tetraspanin 31 -2.12637
NOP56 NOP56 ribonucleoprotein -2.11935
ING4 inhibitor of growth family, member 4 -2.1156
CDH22 cadherin 22, type 2 -2.1111
PUS1 pseudouridylate synthase 1 -2.10955
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.10745
GLTP glycolipid transfer protein -2.104
CHUK conserved helix-loop-helix ubiquitous kinase -2.09645
FLG filaggrin -2.0909
PNRC1 proline-rich nuclear receptor coactivator 1 -2.08665
AKR1C3 aldo-keto reductase family 1, member C3 -2.08425
CD300C CD300c molecule -2.07305
AKR1C1 aldo-keto reductase family 1, member C1 -2.0727
AMACR alpha-methylacyl-CoA racemase -2.07175
DHRS4 dehydrogenase/reductase (SDR family) member 4 -2.07125
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.06787
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -2.0612
FLCN folliculin -2.0594
ATRN attractin -2.05827
MSMB microseminoprotein, beta- -2.04868
SETD3 SET domain containing 3 -2.0453
SNX5 sorting nexin 5 -2.04055
HP1BP3 heterochromatin protein 1, binding protein 3 -2.0329
ABHD11 abhydrolase domain containing 11 -2.0256
RBBP5 retinoblastoma binding protein 5 -2.01995
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -2.01565
COX5A cytochrome c oxidase subunit Va -2.00875
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.00715
IPP intracisternal A particle-promoted polypeptide -2.003