CRCGN015_MCF10A.TP53.M_24H:F01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethylstilbestrol 100.46 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

233 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IL1B interleukin 1, beta 7.586
CXCL2 chemokine (C-X-C motif) ligand 2 7.01304
HMOX1 heme oxygenase 1 5.35063
CTSL cathepsin L 4.96736
UGDH UDP-glucose 6-dehydrogenase 4.96582
KCTD5 potassium channel tetramerization domain containing 5 4.50919
IER3 immediate early response 3 4.49824
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 4.2987
FKBP14 FK506 binding protein 14, 22 kDa 4.14043
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 4.13821
NUCB2 nucleobindin 2 4.06295
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.98226
TNIP1 TNFAIP3 interacting protein 1 3.88062
CCNA1 cyclin A1 3.44103
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.30008
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.22303
AXIN1 axin 1 3.16999
H2BC12 H2B clustered histone 12 3.11276
FHL2 four and a half LIM domains 2 3.0854
VAT1 vesicle amine transport 1 3.05764
RIC8A RIC8 guanine nucleotide exchange factor A 3.03275
CHIC2 cysteine-rich hydrophobic domain 2 2.99056
IGF1R insulin-like growth factor 1 receptor 2.94752
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.89699
CXCL3 chemokine (C-X-C motif) ligand 3 2.85596
ABHD6 abhydrolase domain containing 6 2.80104
HSPA1A heat shock 70kDa protein 1A 2.79224
PYCR1 pyrroline-5-carboxylate reductase 1 2.7745
HBA1 hemoglobin, alpha 1 2.76685
SQSTM1 sequestosome 1 2.76648
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.62318
KIF5C kinesin family member 5C 2.6106
STC2 stanniocalcin 2 2.58116
G0S2 G0/G1 switch 2 2.57935
HBEGF heparin-binding EGF-like growth factor 2.54634
CANT1 calcium activated nucleotidase 1 2.54403
STX4 syntaxin 4 2.54265
FAT1 FAT atypical cadherin 1 2.50865
KIFC3 kinesin family member C3 2.4711
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.4621
CEMIP2 cell migration inducing hyaluronidase 2 2.45871
RPN1 ribophorin I 2.45176
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.44615
CDPF1 cysteine-rich, DPF motif domain containing 1 2.43678
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.42686
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.32011
GARS1 glycyl-tRNA synthetase 1 2.29411
RGS2 regulator of G-protein signaling 2 2.2735
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.2732
GLRX glutaredoxin (thioltransferase) 2.27079
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.25914
LIF leukemia inhibitory factor 2.25602
CXCL8 chemokine (C-X-C motif) ligand 8 2.22969
BMP4 bone morphogenetic protein 4 2.22488
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.2191
IL6 interleukin 6 2.20756
TERF2IP telomeric repeat binding factor 2, interacting protein 2.20362
MMP1 matrix metallopeptidase 1 2.20022
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.1979
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.19725
WDR44 WD repeat domain 44 2.19681
DENND5A DENN/MADD domain containing 5A 2.17923
KLHL36 kelch-like family member 36 2.14568
CSNK1E casein kinase 1, epsilon 2.134
TXNRD1 thioredoxin reductase 1 2.12565
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.11787
KLHL21 kelch-like family member 21 2.11021
COPB1 coatomer protein complex, subunit beta 1 2.10677
ZC3H12A zinc finger CCCH-type containing 12A 2.10031
IL11 interleukin 11 2.09824
EPHA2 EPH receptor A2 2.09726
XPO6 exportin 6 2.09563
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.09471
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 2.0781
IL1A interleukin 1, alpha 2.06376
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.06275
PXDC1 PX domain containing 1 2.05752
CCL4 chemokine (C-C motif) ligand 4 2.05388
SAA2 serum amyloid A2 2.05019
SMAD3 SMAD family member 3 2.04867
CCL20 chemokine (C-C motif) ligand 20 2.04716
CCDC92 coiled-coil domain containing 92 2.03493
IL24 interleukin 24 2.02883
TBXA2R thromboxane A2 receptor 2.02638
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.01604
NAP1L4 nucleosome assembly protein 1-like 4 2.01438
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.01087

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -6.67426
SCYL3 SCY1-like 3 (S. cerevisiae) -4.49907
CCNB1 cyclin B1 -4.23443
PRPF4 pre-mRNA processing factor 4 -4.17305
PRR15L proline rich 15-like -4.10074
CDC45 cell division cycle 45 -4.05866
RPIA ribose 5-phosphate isomerase A -4.00835
MSMO1 methylsterol monooxygenase 1 -3.96498
TRAP1 TNF receptor-associated protein 1 -3.73221
KIF20A kinesin family member 20A -3.61959
TCEA2 transcription elongation factor A (SII), 2 -3.57917
HEATR1 HEAT repeat containing 1 -3.56431
CDC20 cell division cycle 20 -3.43491
MRPS2 mitochondrial ribosomal protein S2 -3.29298
ZNF280D zinc finger protein 280D -3.29141
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.23417
OXA1L oxidase (cytochrome c) assembly 1-like -3.20652
TRIP13 thyroid hormone receptor interactor 13 -3.15498
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -3.12925
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.09756
TSC22D3 TSC22 domain family, member 3 -3.09095
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.08008
ALDOC aldolase C, fructose-bisphosphate -3.02623
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.02485
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.96806
CDK1 cyclin-dependent kinase 1 -2.90274
SCGB1D1 secretoglobin, family 1D, member 1 -2.82744
MRPS16 mitochondrial ribosomal protein S16 -2.76907
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.75583
ALAD aminolevulinate dehydratase -2.73166
XPA xeroderma pigmentosum, complementation group A -2.72964
HADH hydroxyacyl-CoA dehydrogenase -2.67009
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.66452
TP53 tumor protein p53 -2.65848
EML4 echinoderm microtubule associated protein like 4 -2.615
ZNF571 zinc finger protein 571 -2.60915
CD302 CD302 molecule -2.60755
C1QBP complement component 1, q subcomponent binding protein -2.59396
RPS5 ribosomal protein S5 -2.59123
LOC128966570 alpha-amylase 1B -2.57127
TFDP1 transcription factor Dp-1 -2.5441
TCTN1 tectonic family member 1 -2.54037
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.53702
CAPN1 calpain 1, (mu/I) large subunit -2.52798
RNF103-CHMP3 RNF103-CHMP3 readthrough -2.5209
ABITRAM actin binding transcription modulator -2.51322
SH3D19 SH3 domain containing 19 -2.50761
CRTAP cartilage associated protein -2.49629
NELFCD negative elongation factor complex member C/D -2.48679
VDAC1 voltage-dependent anion channel 1 -2.47643
MRPL12 mitochondrial ribosomal protein L12 -2.46556
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.46499
GNAS GNAS complex locus -2.45379
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.45335
INSIG1 insulin induced gene 1 -2.45221
BSPRY B-box and SPRY domain containing -2.45179
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.45132
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.44393
NFIL3 nuclear factor, interleukin 3 regulated -2.42236
ZNF510 zinc finger protein 510 -2.42128
FASTKD3 FAST kinase domains 3 -2.41434
CD58 CD58 molecule -2.40493
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.40168
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.40031
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.38798
LRP5 low density lipoprotein receptor-related protein 5 -2.36444
CD320 CD320 molecule -2.36401
GYG1 glycogenin 1 -2.35203
GTF2A2 general transcription factor IIA, 2, 12kDa -2.33466
WDR70 WD repeat domain 70 -2.32665
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.32192
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.32002
OCLN occludin -2.30276
TROAP trophinin associated protein -2.30118
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.29577
TRIM52 tripartite motif containing 52 -2.28905
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.27623
SIDT1 SID1 transmembrane family, member 1 -2.27526
BZW2 basic leucine zipper and W2 domains 2 -2.26381
ZNF529 zinc finger protein 529 -2.25917
GRID1 glutamate receptor, ionotropic, delta 1 -2.25879
TSPAN3 tetraspanin 3 -2.25355
TRAT1 T cell receptor associated transmembrane adaptor 1 -2.25285
SINHCAF SIN3-HDAC complex associated factor -2.24778
MYZAP myocardial zonula adherens protein -2.23614
STX17 syntaxin 17 -2.21439
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.21403
RAD51C RAD51 paralog C -2.20651
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 -2.18961
VGLL3 vestigial-like family member 3 -2.1888
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.17898
DPYD dihydropyrimidine dehydrogenase -2.1764
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.17295
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.16618
MX2 MX dynamin-like GTPase 2 -2.16436
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.16241
FPGS folylpolyglutamate synthase -2.15057
STOML2 stomatin (EPB72)-like 2 -2.14905
RPL10A ribosomal protein L10a -2.14898
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.14751
PLAC8 placenta-specific 8 -2.14688
EEF2 eukaryotic translation elongation factor 2 -2.13788
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -2.13761
NCBP1 nuclear cap binding protein subunit 1, 80kDa -2.13243
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -2.13126
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.12755
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.11806
RAB33B RAB33B, member RAS oncogene family -2.11232
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.11045
DCAF17 DDB1 and CUL4 associated factor 17 -2.10015
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.07727
WDR33 WD repeat domain 33 -2.07695
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.07661
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.0763
NUP133 nucleoporin 133kDa -2.07579
RAD23B RAD23 homolog B (S. cerevisiae) -2.07359
TIPRL TOR signaling pathway regulator -2.07228
USP39 ubiquitin specific peptidase 39 -2.07175
BPIFA1 BPI fold containing family A, member 1 -2.07091
NYNRIN NYN domain and retroviral integrase containing -2.06817
NKRF NFKB repressing factor -2.06426
MCPH1 microcephalin 1 -2.05971
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.05761
PEX11B peroxisomal biogenesis factor 11 beta -2.05238
ADI1 acireductone dioxygenase 1 -2.05214
CD46 CD46 molecule, complement regulatory protein -2.04547
DAND5 DAN domain family member 5, BMP antagonist -2.04428
ABI3BP ABI family, member 3 (NESH) binding protein -2.04273
ELOVL6 ELOVL fatty acid elongase 6 -2.03834
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -2.03571
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.03442
PLSCR1 phospholipid scramblase 1 -2.03247
CCNA2 cyclin A2 -2.03139
TPX2 TPX2, microtubule-associated -2.02632
PEX13 peroxisomal biogenesis factor 13 -2.02442
ADAMTSL3 ADAMTS-like 3 -2.02361
CS citrate synthase -2.02063
PPP6C protein phosphatase 6, catalytic subunit -2.01701
CDC42 cell division cycle 42 -2.01628
COQ4 coenzyme Q4 -2.01376
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.01364
SCAI suppressor of cancer cell invasion -2.01258
BIRC5 baculoviral IAP repeat containing 5 -2.01069
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.00473
MUC1 mucin 1, cell surface associated -2.00421
ODF2 outer dense fiber of sperm tails 2 -2.00196