CRCGN015_MCF10A.TP53.M_24H:F02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethylstilbestrol 33.49 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.87179
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.18312
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.73232
MAMLD1 mastermind-like domain containing 1 2.7253
LOC122526780 uncharacterized LOC122526780 2.61688
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.60331
HBA1 hemoglobin, alpha 1 2.5748
CCDC92 coiled-coil domain containing 92 2.47347
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.46527
SNX11 sorting nexin 11 2.36278
PLSCR1 phospholipid scramblase 1 2.33105
MAGEF1 melanoma antigen family F1 2.31553
HYOU1 hypoxia up-regulated 1 2.29473
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.2239
ACAA1 acetyl-CoA acyltransferase 1 2.21983
GPER1 G protein-coupled estrogen receptor 1 2.20121
EPN2 epsin 2 2.16966
EMC2 ER membrane protein complex subunit 2 2.11206
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.09839
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.03888
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.01928

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -4.76344
UFM1 ubiquitin-fold modifier 1 -4.34494
CCNB1 cyclin B1 -3.74959
HAT1 histone acetyltransferase 1 -3.18035
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.12689
NVL nuclear VCP-like -3.06297
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.94517
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.90756
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.86167
CAPN2 calpain 2, (m/II) large subunit -2.76105
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.67833
MSMO1 methylsterol monooxygenase 1 -2.58253
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.5695
CD81 CD81 molecule -2.56873
ADRB2 adrenoceptor beta 2, surface -2.55931
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.39131
TES testin LIM domain protein -2.30548
NEK7 NIMA-related kinase 7 -2.25861
WASHC4 WASH complex subunit 4 -2.24576
SLC35A5 solute carrier family 35, member A5 -2.23679
DSG1 desmoglein 1 -2.20304
LORICRIN loricrin cornified envelope precursor protein -2.18484
DUSP14 dual specificity phosphatase 14 -2.18151
CDK4 cyclin-dependent kinase 4 -2.17665
CTNND1 catenin (cadherin-associated protein), delta 1 -2.16837
AKAP11 A kinase (PRKA) anchor protein 11 -2.12781
LOC112694756 uncharaterized LOC112694756 -2.1174
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.10185
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.10173
ATG3 autophagy related 3 -2.077
RALGDS ral guanine nucleotide dissociation stimulator -2.07646
FBXO28 F-box protein 28 -2.06389
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.01112
KRT1 keratin 1, type II -2.00959
EPPK1 epiplakin 1 -2.00309
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.00148