CRCGN015_MCF10A.TP53.M_24H:F05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 34.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WFS1 Wolfram syndrome 1 (wolframin) 3.83583
RPL39L ribosomal protein L39-like 3.41151
C2CD2 C2 calcium-dependent domain containing 2 3.33071
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.01609
AGR2 anterior gradient 2 2.44286
HBB hemoglobin, beta 2.40869
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.40739
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.2242
FGFR4 fibroblast growth factor receptor 4 2.17442
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.16498
TOMM34 translocase of outer mitochondrial membrane 34 2.14227
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.07786
TIAM1 T-cell lymphoma invasion and metastasis 1 2.05223

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.29626
TEX10 testis expressed 10 -3.59379
YME1L1 YME1-like 1 ATPase -3.47358
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.43306
GRN granulin -3.31599
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.31336
CDC45 cell division cycle 45 -3.24917
THAP11 THAP domain containing 11 -3.21805
GNAS GNAS complex locus -2.80066
OXA1L oxidase (cytochrome c) assembly 1-like -2.69444
TIMP1 TIMP metallopeptidase inhibitor 1 -2.48358
NIPAL2 NIPA-like domain containing 2 -2.08056