CRCGN015_MCF10A.TP53.M_24H:F06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 11.39 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 6.29505
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.2394
STAP2 signal transducing adaptor family member 2 4.30281
E2F2 E2F transcription factor 2 4.1017
MEF2C myocyte enhancer factor 2C 3.94936
SPAG4 sperm associated antigen 4 3.70319
CXCL2 chemokine (C-X-C motif) ligand 2 3.49363
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.465
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.54234
BACE2 beta-site APP-cleaving enzyme 2 2.52568
SMPX small muscle protein, X-linked 2.4151
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 2.39738
AXIN1 axin 1 2.3628
IGHMBP2 immunoglobulin mu binding protein 2 2.30689
TNNT3 troponin T type 3 (skeletal, fast) 2.3064
TNNC2 troponin C type 2 (fast) 2.29184
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.29051
MCUR1 mitochondrial calcium uniporter regulator 1 2.28961
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.26411
MYOT myotilin 2.24696
HBA1 hemoglobin, alpha 1 2.22543
MYL11 myosin light chain 11 2.20289
TPM3 tropomyosin 3 2.15224
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.14877
TNNI1 troponin I type 1 (skeletal, slow) 2.14165
RERGL RERG/RAS-like 2.12078
HRC histidine rich calcium binding protein 2.11111
HOMER1 homer scaffolding protein 1 2.0985
PTPRK protein tyrosine phosphatase, receptor type, K 2.09557
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 2.07987
DUSP13A dual specificity phosphatase 13A 2.0764
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.07311
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.06891
PGM5 phosphoglucomutase 5 2.02723
ADGRF5 adhesion G protein-coupled receptor F5 2.0175
PYGM phosphorylase, glycogen, muscle 2.01715
CKM creatine kinase, muscle 2.01483
TBX2 T-box 2 2.00967
PCCA propionyl CoA carboxylase, alpha polypeptide 2.00298

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -4.05396
KRT14 keratin 14, type I -3.89847
PMM2 phosphomannomutase 2 -3.72616
TRAPPC3 trafficking protein particle complex 3 -3.52877
OXA1L oxidase (cytochrome c) assembly 1-like -3.40125
HMG20B high mobility group 20B -3.19879
RPS5 ribosomal protein S5 -3.14042
DCK deoxycytidine kinase -2.99934
CANT1 calcium activated nucleotidase 1 -2.61703
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.30234
WAPL WAPL cohesin release factor -2.28723
PRPF4 pre-mRNA processing factor 4 -2.20053
RBM34 RNA binding motif protein 34 -2.15906
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.09015
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.0809
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -2.07386
HOXA7 homeobox A7 -2.05721
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.01789