CRCGN015_MCF10A.TP53.M_24H:F08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorocyclopentadiene 33.82 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.9476
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.78245
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.09355
MOK MOK protein kinase 3.62875
TSPAN6 tetraspanin 6 3.41895
TLCD3A TLC domain containing 3A 3.1631
GPATCH8 G patch domain containing 8 2.89208
PDLIM1 PDZ and LIM domain 1 2.84655
COQ8A coenzyme Q8A 2.72065
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.59
GSTZ1 glutathione S-transferase zeta 1 2.5884
MELK maternal embryonic leucine zipper kinase 2.45355
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.40405
SAP30 Sin3A-associated protein, 30kDa 2.26423
DMBT1 deleted in malignant brain tumors 1 2.17395
FBL fibrillarin 2.13865
MMP1 matrix metallopeptidase 1 2.13175
F13A1 coagulation factor XIII, A1 polypeptide 2.11505

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -5.344
COG2 component of oligomeric golgi complex 2 -5.0226
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.3857
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.9964
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.7666
MSMO1 methylsterol monooxygenase 1 -3.34345
SGK1 serum/glucocorticoid regulated kinase 1 -3.2188
CD81 CD81 molecule -3.04075
MTFR1 mitochondrial fission regulator 1 -2.99482
SCRN3 secernin 3 -2.68165
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.68055
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.48425
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.40053
ADGRB2 adhesion G protein-coupled receptor B2 -2.3512
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.34497
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.3191
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.29655
CETN2 centrin, EF-hand protein, 2 -2.29045
RAB3A RAB3A, member RAS oncogene family -2.28195
GRWD1 glutamate-rich WD repeat containing 1 -2.2807
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.23295
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -2.21065
TEX11 testis expressed 11 -2.189
RBM15B RNA binding motif protein 15B -2.1384
PEX7 peroxisomal biogenesis factor 7 -2.11372
ZBTB48 zinc finger and BTB domain containing 48 -2.09885
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -2.0865
CAPN9 calpain 9 -2.086
SPRING1 SREBF pathway regulator in golgi 1 -2.0799
LEFTY1 left-right determination factor 1 -2.0768
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.07155
NLRP4 NLR family, pyrin domain containing 4 -2.03975
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -2.03932
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.02565
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.0147
CCNK cyclin K -2.00205
CAB39L calcium binding protein 39-like -2.0017