CRCGN015_MCF10A.TP53.M_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 101.47 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

131 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 6.8206
CRELD2 cysteine-rich with EGF-like domains 2 5.34075
LGMN legumain 5.3193
DENND2D DENN/MADD domain containing 2D 5.3157
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 5.21605
CCDC92 coiled-coil domain containing 92 4.1217
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4.05719
PRR7 proline rich 7 (synaptic) 3.81125
TXNL4B thioredoxin-like 4B 3.8057
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.58433
SDF2L1 stromal cell-derived factor 2-like 1 3.28495
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.86057
C5 complement component 5 2.79125
HBA1 hemoglobin, alpha 1 2.78468
SPDEF SAM pointed domain containing ETS transcription factor 2.72207
TLK2 tousled-like kinase 2 2.64708
ABHD6 abhydrolase domain containing 6 2.64587
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.61205
MANF mesencephalic astrocyte-derived neurotrophic factor 2.5609
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.5371
ACSL6 acyl-CoA synthetase long-chain family member 6 2.50378
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.46185
SYK spleen tyrosine kinase 2.45687
GTPBP8 GTP-binding protein 8 (putative) 2.44565
PDIA4 protein disulfide isomerase family A, member 4 2.44317
ANXA6 annexin A6 2.39445
PDIA6 protein disulfide isomerase family A, member 6 2.37109
LYN LYN proto-oncogene, Src family tyrosine kinase 2.366
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.35955
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.3287
MTUS2 microtubule associated tumor suppressor candidate 2 2.24595
PECR peroxisomal trans-2-enoyl-CoA reductase 2.2442
KDM3A lysine (K)-specific demethylase 3A 2.2403
BEX2 brain expressed X-linked 2 2.23135
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.2077
TMED9 transmembrane emp24 protein transport domain containing 9 2.18397
NISCH nischarin 2.1756
TLR5 toll-like receptor 5 2.17165
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.164
CHI3L2 chitinase 3-like 2 2.159
TMEM176A transmembrane protein 176A 2.15825
OR7A5 olfactory receptor, family 7, subfamily A, member 5 2.13905
ISOC2 isochorismatase domain containing 2 2.12635
GSTCD glutathione S-transferase, C-terminal domain containing 2.1252
GSAP gamma-secretase activating protein 2.12108
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.1176
FKBP10 FK506 binding protein 10, 65 kDa 2.11135
PARN poly(A)-specific ribonuclease 2.1113
CTSO cathepsin O 2.10525
ZNF287 zinc finger protein 287 2.09815
EXOC2 exocyst complex component 2 2.0922
GDAP1 ganglioside induced differentiation associated protein 1 2.0853
CD302 CD302 molecule 2.0775
SIX6 SIX homeobox 6 2.0717
SCN1A sodium channel, voltage gated, type I alpha subunit 2.0711
NAP1L2 nucleosome assembly protein 1-like 2 2.07015
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.06325
TENM1 teneurin transmembrane protein 1 2.0628
DMAC2L distal membrane arm assembly component 2 like 2.05637
TIMP4 TIMP metallopeptidase inhibitor 4 2.04665
LPXN leupaxin 2.04665
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.04145
EPHA5 EPH receptor A5 2.041
LAPTM5 lysosomal protein transmembrane 5 2.038
DZIP3 DAZ interacting zinc finger protein 3 2.03743
PDE8B phosphodiesterase 8B 2.0366
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.03625
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.03365
CAPN6 calpain 6 2.03212
ELOVL2 ELOVL fatty acid elongase 2 2.01697
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.0167
FOS FBJ murine osteosarcoma viral oncogene homolog 2.0161
TOX thymocyte selection-associated high mobility group box 2.01533
LIFR leukemia inhibitory factor receptor alpha 2.0143
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.01265
TEX10 testis expressed 10 2.01155
ARHGAP24 Rho GTPase activating protein 24 2.0047
MAP9 microtubule-associated protein 9 2.00375

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -4.92965
ARPP19 cAMP-regulated phosphoprotein, 19kDa -4.88497
NPDC1 neural proliferation, differentiation and control, 1 -4.7868
CHIC2 cysteine-rich hydrophobic domain 2 -4.72505
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.5413
CD58 CD58 molecule -4.25762
NVL nuclear VCP-like -3.64305
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.23195
STAT1 signal transducer and activator of transcription 1, 91kDa -3.15207
NGRN neugrin, neurite outgrowth associated -2.9737
ITPRID2 ITPR interacting domain containing 2 -2.9568
TM9SF2 transmembrane 9 superfamily member 2 -2.83155
PRCP prolylcarboxypeptidase (angiotensinase C) -2.82625
RGS2 regulator of G-protein signaling 2 -2.8192
CAB39 calcium binding protein 39 -2.76365
CAPN2 calpain 2, (m/II) large subunit -2.7473
TSG101 tumor susceptibility 101 -2.55185
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.546
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.5431
NOP10 NOP10 ribonucleoprotein -2.46535
FBXO28 F-box protein 28 -2.45295
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.4326
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.43255
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.3123
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -2.29695
SAR1B secretion associated, Ras related GTPase 1B -2.2715
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.27014
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -2.25925
MRPL18 mitochondrial ribosomal protein L18 -2.2561
CYBRD1 cytochrome b reductase 1 -2.25135
KIF23 kinesin family member 23 -2.24085
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.2309
SEC24C SEC24 family member C -2.22065
ADIPOR1 adiponectin receptor 1 -2.1932
REXO2 RNA exonuclease 2 -2.1857
TRIB3 tribbles pseudokinase 3 -2.18285
CYTH2 cytohesin 2 -2.16305
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.16125
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.15445
CLDN4 claudin 4 -2.147
RPS5 ribosomal protein S5 -2.1458
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -2.1431
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.1315
DCTN6 dynactin 6 -2.11455
ULBP2 UL16 binding protein 2 -2.1046
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.10115
ATP11B ATPase, class VI, type 11B -2.084
GRWD1 glutamate-rich WD repeat containing 1 -2.07625
RHOB ras homolog family member B -2.06965
RAB9A RAB9A, member RAS oncogene family -2.06135
REEP5 receptor accessory protein 5 -2.04175
CERS2 ceramide synthase 2 -2.0326
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.02325