CRCGN015_MCF10A.TP53.M_24H:F13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 101.47 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

155 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IGHMBP2 immunoglobulin mu binding protein 2 6.60255
IDE insulin-degrading enzyme 5.91302
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.57091
LAGE3 L antigen family, member 3 5.53045
AMDHD2 amidohydrolase domain containing 2 5.06265
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.71465
CHMP6 charged multivesicular body protein 6 4.63885
SPAG4 sperm associated antigen 4 4.37055
SSBP2 single-stranded DNA binding protein 2 4.29957
ACAA1 acetyl-CoA acyltransferase 1 3.88215
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.63995
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.51855
ZDHHC24 zinc finger, DHHC-type containing 24 3.4271
DUX4 double homeobox 4 3.1556
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.1427
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 3.1328
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.11495
PDLIM1 PDZ and LIM domain 1 3.07895
PDCD1 programmed cell death 1 3.05835
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.9574
MGMT O-6-methylguanine-DNA methyltransferase 2.8289
EMD emerin 2.80635
TLE6 transducin-like enhancer of split 6 2.79865
ENOSF1 enolase superfamily member 1 2.78419
SATB1 SATB homeobox 1 2.7829
INPP5J inositol polyphosphate-5-phosphatase J 2.7496
NT5C 5', 3'-nucleotidase, cytosolic 2.6653
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.6276
GALK1 galactokinase 1 2.62705
VBP1 von Hippel-Lindau binding protein 1 2.62065
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.5955
MNMIP1 manchette microtubule inner protein 1 2.59455
FAM3A family with sequence similarity 3, member A 2.5918
MRPL30 mitochondrial ribosomal protein L30 2.5765
UBL4A ubiquitin-like 4A 2.56233
MTG1 mitochondrial ribosome-associated GTPase 1 2.5569
FAM50A family with sequence similarity 50, member A 2.5507
LORICRIN loricrin cornified envelope precursor protein 2.5425
SCAND1 SCAN domain containing 1 2.52635
CYTH3 cytohesin 3 2.5076
WRAP53 WD repeat containing, antisense to TP53 2.47467
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.4402
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.4166
RXYLT1 ribitol xylosyltransferase 1 2.41267
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.4065
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 2.4027
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.39805
JMJD7 jumonji domain containing 7 2.3964
TTC12 tetratricopeptide repeat domain 12 2.3921
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.3899
FAAP100 FA core complex associated protein 100 2.3883
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.3734
FTO fat mass and obesity associated 2.35405
IRAK1 interleukin-1 receptor-associated kinase 1 2.3451
SSR4 signal sequence receptor, delta 2.34505
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.34435
USP19 ubiquitin specific peptidase 19 2.3391
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.3378
ZBTB7B zinc finger and BTB domain containing 7B 2.3342
TYRP1 tyrosinase-related protein 1 2.3316
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.32855
MATN4 matrilin 4 2.3209
RAX retina and anterior neural fold homeobox 2.31835
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.31635
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.3089
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.2824
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 2.27005
EIF6 eukaryotic translation initiation factor 6 2.2697
TMEM208 transmembrane protein 208 2.26725
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.26657
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.2554
TOM1L1 target of myb1 (chicken)-like 1 2.2327
SCT secretin 2.2321
SPRR2B small proline-rich protein 2B 2.2309
LCE2B late cornified envelope 2B 2.22975
GGT5 gamma-glutamyltransferase 5 2.2069
DSG1 desmoglein 1 2.205
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.2014
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.19895
CDSN corneodesmosin 2.19147
GMPPB GDP-mannose pyrophosphorylase B 2.18745
SMYD2 SET and MYND domain containing 2 2.1851
ASB6 ankyrin repeat and SOCS box containing 6 2.15135
RHOT2 ras homolog family member T2 2.14983
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.1464
PNMA3 paraneoplastic Ma antigen 3 2.13985
ACOT2 acyl-CoA thioesterase 2 2.1368
CYB561D2 cytochrome b561 family, member D2 2.1215
MORN1 MORN repeat containing 1 2.11835
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.11488
UROS uroporphyrinogen III synthase 2.0975
POMC proopiomelanocortin 2.0937
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.08428
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.07365
MRPL12 mitochondrial ribosomal protein L12 2.0684
LGALS7B lectin, galactoside-binding, soluble, 7B 2.0674
TRAF4 TNF receptor-associated factor 4 2.06145
SLC46A3 solute carrier family 46, member 3 2.0575
LGALS14 lectin, galactoside-binding, soluble, 14 2.0538
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.0479
NUP43 nucleoporin 43kDa 2.03625
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.03505
MICB MHC class I polypeptide-related sequence B 2.03335
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.0302
HROB homologous recombination factor with OB-fold 2.0136
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 2.0134

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.18125
CCNB2 cyclin B2 -5.06235
ADI1 acireductone dioxygenase 1 -4.7887
SGK1 serum/glucocorticoid regulated kinase 1 -4.27025
HOXA5 homeobox A5 -3.97625
ATF5 activating transcription factor 5 -3.4984
PSIP1 PC4 and SFRS1 interacting protein 1 -3.4525
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.93085
SHROOM2 shroom family member 2 -2.8407
IPO13 importin 13 -2.75985
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.71925
HDAC4 histone deacetylase 4 -2.7038
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -2.52275
JAK2 Janus kinase 2 -2.49552
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.48635
TCEAL4 transcription elongation factor A (SII)-like 4 -2.4214
DHCR24 24-dehydrocholesterol reductase -2.407
TRIM36 tripartite motif containing 36 -2.3935
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.3426
RFPL2 ret finger protein-like 2 -2.3236
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.31335
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 -2.29959
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.2895
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.2774
ATP11B ATPase, class VI, type 11B -2.2771
RNF111 ring finger protein 111 -2.2353
RHEX regulator of hemoglobinization and erythroid cell expansion -2.23438
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.22155
NOPCHAP1 NOP protein chaperone 1 -2.2202
DHRS9 dehydrogenase/reductase (SDR family) member 9 -2.1907
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.18955
MAP2K1 mitogen-activated protein kinase kinase 1 -2.17945
ACP3 acid phosphatase 3 -2.15575
CSRP1 cysteine and glycine-rich protein 1 -2.14752
DCLRE1B DNA cross-link repair 1B -2.1209
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.10635
RFPL3 ret finger protein-like 3 -2.0913
OXR1 oxidation resistance 1 -2.0749
FAM107A family with sequence similarity 107, member A -2.07253
FANCF Fanconi anemia, complementation group F -2.0664
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.05325
GCC2 GRIP and coiled-coil domain containing 2 -2.0521
SIN3B SIN3 transcription regulator family member B -2.0488
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -2.04425
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.0419
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.02935
KLK2 kallikrein-related peptidase 2 -2.02653
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -2.01825
TYROBP TYRO protein tyrosine kinase binding protein -2.00835