CRCGN015_MCF10A.TP53.M_24H:F14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 33.82 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.66167
AGR2 anterior gradient 2 5.0
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.96413
KCTD5 potassium channel tetramerization domain containing 5 4.58745
CCDC85B coiled-coil domain containing 85B 4.43625
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.3762
KIF5C kinesin family member 5C 4.30325
VAV3 vav 3 guanine nucleotide exchange factor 4.27723
NUTF2 nuclear transport factor 2 3.36665
HDGFL3 HDGF like 3 3.33857
MTA2 metastasis associated 1 family, member 2 3.1906
WIF1 WNT inhibitory factor 1 3.07615
NSG2 neuronal vesicle trafficking associated 2 2.97695
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.76148
STMN2 stathmin 2 2.7465
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.67335
SATB1 SATB homeobox 1 2.6089
SNAP91 synaptosomal-associated protein, 91kDa 2.5566
PARP16 poly (ADP-ribose) polymerase family, member 16 2.52285
THRAP3 thyroid hormone receptor associated protein 3 2.48335
POU4F1 POU class 4 homeobox 1 2.44668
KIAA0513 KIAA0513 2.43795
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.43645
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) 2.43205
NEFM neurofilament, medium polypeptide 2.42745
PCSK2 proprotein convertase subtilisin/kexin type 2 2.40007
MAP2K5 mitogen-activated protein kinase kinase 5 2.37918
RGS4 regulator of G-protein signaling 4 2.3335
RGS7 regulator of G-protein signaling 7 2.32565
GALNS galactosamine (N-acetyl)-6-sulfatase 2.3103
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.2829
CHURC1-FNTB CHURC1-FNTB readthrough 2.27563
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 2.2614
HMGB2 high mobility group box 2 2.25015
NSF N-ethylmaleimide-sensitive factor 2.2314
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.223
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.21055
VSNL1 visinin-like 1 2.20325
PI15 peptidase inhibitor 15 2.17675
GPSM2 G-protein signaling modulator 2 2.16797
SCD5 stearoyl-CoA desaturase 5 2.16275
SPACA9 sperm acrosome associated 9 2.1541
NEFL neurofilament, light polypeptide 2.15333
PTPRS protein tyrosine phosphatase, receptor type, S 2.1201
GDF7 growth differentiation factor 7 2.12
SMAGP small cell adhesion glycoprotein 2.1158
OSGEP O-sialoglycoprotein endopeptidase 2.1085
DGKD diacylglycerol kinase, delta 130kDa 2.09335
AGTR1 angiotensin II receptor, type 1 2.09008
HOXB9 homeobox B9 2.06595
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.06205
DCTN4 dynactin 4 (p62) 2.05195
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.0167
WDR5B WD repeat domain 5B 2.0139

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -5.4925
NPDC1 neural proliferation, differentiation and control, 1 -5.1388
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.85642
KIF14 kinesin family member 14 -4.7892
COTL1 coactosin-like F-actin binding protein 1 -4.5793
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.54175
HEATR1 HEAT repeat containing 1 -4.5057
HSPA8 heat shock 70kDa protein 8 -4.45425
CD44 CD44 molecule (Indian blood group) -4.35135
TM9SF3 transmembrane 9 superfamily member 3 -4.26745
HMG20B high mobility group 20B -4.15707
LYPLA1 lysophospholipase I -3.76585
NRIP1 nuclear receptor interacting protein 1 -3.6422
CD81 CD81 molecule -3.40095
ANKRD10 ankyrin repeat domain 10 -2.7908
COL7A1 collagen, type VII, alpha 1 -2.55095
LTBP4 latent transforming growth factor beta binding protein 4 -2.51615
MAGT1 magnesium transporter 1 -2.44965
PRDX4 peroxiredoxin 4 -2.4076
SH2B2 SH2B adaptor protein 2 -2.3991
IL7R interleukin 7 receptor -2.36145
SLAMF7 SLAM family member 7 -2.3487
INPP5K inositol polyphosphate-5-phosphatase K -2.32643
CNPY3 canopy FGF signaling regulator 3 -2.2858
MICB MHC class I polypeptide-related sequence B -2.2753
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.24485
CEP170 centrosomal protein 170kDa -2.23315
KRT14 keratin 14, type I -2.21065
GSDME gasdermin E -2.2096
RTL8A retrotransposon Gag like 8A -2.17365
NES nestin -2.16305
POU2AF1 POU class 2 associating factor 1 -2.1395
WTAP Wilms tumor 1 associated protein -2.13895
TNIP3 TNFAIP3 interacting protein 3 -2.1238
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.0935
ACOT2 acyl-CoA thioesterase 2 -2.0917
KLF13 Kruppel-like factor 13 -2.08425
ARSA arylsulfatase A -2.08315
BEX3 brain expressed X-linked 3 -2.0801
CXCL9 chemokine (C-X-C motif) ligand 9 -2.06155
PITPNA phosphatidylinositol transfer protein, alpha -2.06042
EBI3 Epstein-Barr virus induced 3 -2.0389
OGFRL1 opioid growth factor receptor-like 1 -2.0323
CLIC2 chloride intracellular channel 2 -2.02575
KCTD9 potassium channel tetramerization domain containing 9 -2.0249
SPON2 spondin 2, extracellular matrix protein -2.01975
ARHGAP22 Rho GTPase activating protein 22 -2.0195
TNS2 tensin 2 -2.0101
ADGRE2 adhesion G protein-coupled receptor E2 -2.0016