CRCGN015_MCF10A.TP53.M_24H:F15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 11.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.1068
CHMP6 charged multivesicular body protein 6 5.0744
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.4298
SPAG4 sperm associated antigen 4 4.37055
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.95115
ACAA1 acetyl-CoA acyltransferase 1 3.5946
IGHMBP2 immunoglobulin mu binding protein 2 3.44707
MELK maternal embryonic leucine zipper kinase 3.42385
CENPE centromere protein E, 312kDa 2.55845
ACLY ATP citrate lyase 2.54608
CNRIP1 cannabinoid receptor interacting protein 1 2.52765
S1PR4 sphingosine-1-phosphate receptor 4 2.52595
ASL argininosuccinate lyase 2.29795
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.205
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.1948
CTSV cathepsin V 2.13915
SMG9 SMG9 nonsense mediated mRNA decay factor 2.1124
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.0838

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.99097
CCNB1 cyclin B1 -4.9405
GADD45B growth arrest and DNA-damage-inducible, beta -4.62408
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.47005
YME1L1 YME1-like 1 ATPase -4.44492
SGK1 serum/glucocorticoid regulated kinase 1 -3.1429
PCCB propionyl CoA carboxylase, beta polypeptide -2.85545
BASP1 brain abundant, membrane attached signal protein 1 -2.8418
MTPAP mitochondrial poly(A) polymerase -2.57975
ABI1 abl-interactor 1 -2.48657
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.43132
NLK nemo-like kinase -2.24015
ADAMTSL3 ADAMTS-like 3 -2.0138
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.01225