CRCGN015_MCF10A.TP53.M_24H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeic-acid 10.94 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

689 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 10.0
STAP2 signal transducing adaptor family member 2 10.0
SPAG4 sperm associated antigen 4 10.0
PRKCH protein kinase C, eta 9.7042
WIF1 WNT inhibitory factor 1 7.07
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 5.99433
SYT1 synaptotagmin I 5.3809
NSG2 neuronal vesicle trafficking associated 2 5.0744
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 5.0346
SCG3 secretogranin III 5.0174
CASP10 caspase 10, apoptosis-related cysteine peptidase 4.99328
SNAP91 synaptosomal-associated protein, 91kDa 4.9799
SYN1 synapsin I 4.7308
CARTPT CART prepropeptide 4.7307
STMN2 stathmin 2 4.50215
CHN1 chimerin 1 4.3985
STAT4 signal transducer and activator of transcription 4 4.2514
NFU1 NFU1 iron-sulfur cluster scaffold 4.2483
PCSK1 proprotein convertase subtilisin/kexin type 1 4.1262
GSTZ1 glutathione S-transferase zeta 1 4.0833
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 4.08
SCGN secretagogin, EF-hand calcium binding protein 4.0514
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 3.9555
PCSK2 proprotein convertase subtilisin/kexin type 2 3.94055
ICMT isoprenylcysteine carboxyl methyltransferase 3.93113
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 3.8955
ZNF451 zinc finger protein 451 3.8847
TXK TXK tyrosine kinase 3.7575
CCNG1 cyclin G1 3.7528
VSNL1 visinin-like 1 3.72355
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 3.6984
FZD7 frizzled class receptor 7 3.68155
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.5622
CSNK1A1 casein kinase 1, alpha 1 3.55258
DTYMK deoxythymidylate kinase (thymidylate kinase) 3.513
MERTK MER proto-oncogene, tyrosine kinase 3.50745
TESPA1 thymocyte expressed, positive selection associated 1 3.4921
TAC1 tachykinin, precursor 1 3.4781
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 3.45
CCNA1 cyclin A1 3.4493
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.4476
LPIN1 lipin 1 3.3904
FAIM Fas apoptotic inhibitory molecule 3.3873
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 3.3612
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.3294
COL21A1 collagen, type XXI, alpha 1 3.3009
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 3.2988
HIKESHI heat shock protein nuclear import factor hikeshi 3.2768
SCN1A sodium channel, voltage gated, type I alpha subunit 3.2692
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 3.2547
DCLK1 doublecortin-like kinase 1 3.2542
HBB hemoglobin, beta 3.2316
TENT5C terminal nucleotidyltransferase 5C 3.1921
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 3.1886
STARD5 StAR-related lipid transfer (START) domain containing 5 3.1826
LCN2 lipocalin 2 3.1776
NCALD neurocalcin delta 3.1725
RNF144A ring finger protein 144A 3.1671
MELK maternal embryonic leucine zipper kinase 3.1649
HOXD10 homeobox D10 3.145
TMEM50A transmembrane protein 50A 3.1353
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.131
CH25H cholesterol 25-hydroxylase 3.1195
PDYN prodynorphin 3.1045
ADGRL3 adhesion G protein-coupled receptor L3 3.10305
FRK fyn-related Src family tyrosine kinase 3.0979
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 3.08435
DCTN4 dynactin 4 (p62) 3.0745
ADGRB3 adhesion G protein-coupled receptor B3 3.0672
CSN1S1 casein alpha s1 3.0612
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 3.0553
RGS7 regulator of G-protein signaling 7 3.0524
SV2B synaptic vesicle glycoprotein 2B 3.0233
SV2C synaptic vesicle glycoprotein 2C 3.0223
COQ6 coenzyme Q6 monooxygenase 3.0155
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 3.0087
NSF N-ethylmaleimide-sensitive factor 2.9904
QPRT quinolinate phosphoribosyltransferase 2.9699
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.9544
NEFL neurofilament, light polypeptide 2.95287
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.9443
IQSEC3 IQ motif and Sec7 domain 3 2.9407
ITM2C integral membrane protein 2C 2.9345
MUC16 mucin 16, cell surface associated 2.9301
SRD5A3 steroid 5 alpha-reductase 3 2.8897
CTSW cathepsin W 2.8853
ENO2 enolase 2 (gamma, neuronal) 2.8589
TDP1 tyrosyl-DNA phosphodiesterase 1 2.8569
ELL2 elongation factor, RNA polymerase II, 2 2.849
UBA7 ubiquitin-like modifier activating enzyme 7 2.8475
CD96 CD96 molecule 2.8464
CPZ carboxypeptidase Z 2.8461
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.8361
FRRS1L ferric-chelate reductase 1-like 2.8181
PREB prolactin regulatory element binding 2.7995
BLMH bleomycin hydrolase 2.7995
TCIM transcriptional and immune response regulator 2.7947
NEFM neurofilament, medium polypeptide 2.7912
PLAC8 placenta-specific 8 2.7774
RNF113A ring finger protein 113A 2.7732
TAGLN3 transgelin 3 2.7705
KIF4A kinesin family member 4A 2.7648
PRDX4 peroxiredoxin 4 2.7565
OLFM1 olfactomedin 1 2.74777
RUNDC3A RUN domain containing 3A 2.73675
UBB ubiquitin B 2.7345
VGLL1 vestigial-like family member 1 2.7325
LINC02762 long intergenic non-protein coding RNA 2762 2.725
HEXB hexosaminidase B (beta polypeptide) 2.712
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.7058
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 2.6962
CALCRL calcitonin receptor-like 2.68665
NDNF neuron-derived neurotrophic factor 2.6841
LOC128966597 MAL-like protein 2.6779
BARD1 BRCA1 associated RING domain 1 2.6744
ZNF140 zinc finger protein 140 2.6696
SMYD3 SET and MYND domain containing 3 2.6448
ZDHHC7 zinc finger, DHHC-type containing 7 2.6365
GPHN gephyrin 2.6245
SYNJ1 synaptojanin 1 2.6243
CD7 CD7 molecule 2.61955
YY1AP1 YY1 associated protein 1 2.6151
RIBC2 RIB43A domain with coiled-coils 2 2.6057
DCX doublecortin 2.5982
IL22RA1 interleukin 22 receptor, alpha 1 2.597
FAM124B family with sequence similarity 124B 2.5959
CRYM crystallin, mu 2.5952
CPM carboxypeptidase M 2.5919
ASXL2 additional sex combs like transcriptional regulator 2 2.5893
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.5849
FHL5 four and a half LIM domains 5 2.5792
CCL16 chemokine (C-C motif) ligand 16 2.5681
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.5663
SCN1B sodium channel, voltage gated, type I beta subunit 2.5659
SH2D1A SH2 domain containing 1A 2.56425
SCG2 secretogranin II 2.5636
ANO1 anoctamin 1, calcium activated chloride channel 2.5616
MCTS1 malignant T cell amplified sequence 1 2.5613
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.5543
HLA-E major histocompatibility complex, class I, E 2.5528
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.5513
DNAAF5 dynein, axonemal, assembly factor 5 2.5379
PPP1R7 protein phosphatase 1, regulatory subunit 7 2.53653
TSPAN14 tetraspanin 14 2.5349
ICAM2 intercellular adhesion molecule 2 2.5343
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.52735
ACE angiotensin I converting enzyme 2.5256
GJA4 gap junction protein, alpha 4, 37kDa 2.5243
TRAPPC2L trafficking protein particle complex 2-like 2.5203
OSR2 odd-skipped related transciption factor 2 2.52
APOD apolipoprotein D 2.5077
NKX2-2 NK2 homeobox 2 2.5071
PEX13 peroxisomal biogenesis factor 13 2.5067
FGF14 fibroblast growth factor 14 2.5059
PRDM1 PR domain containing 1, with ZNF domain 2.5048
AMPD1 adenosine monophosphate deaminase 1 2.5041
RAB15 RAB15, member RAS oncogene family 2.5036
NECAB3 N-terminal EF-hand calcium binding protein 3 2.5016
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.5013
TCEAL1 transcription elongation factor A (SII)-like 1 2.499
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.4966
AGO2 argonaute RISC catalytic component 2 2.4912
CALCB calcitonin-related polypeptide beta 2.4872
TXNIP thioredoxin interacting protein 2.48603
CKMT1A creatine kinase, mitochondrial 1A 2.4845
DAPK1 death-associated protein kinase 1 2.4775
BBLN bublin coiled coil protein 2.47573
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.4738
GIMAP6 GTPase, IMAP family member 6 2.4738
IFITM1 interferon induced transmembrane protein 1 2.4713
CYBA cytochrome b-245, alpha polypeptide 2.4686
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.4663
OASL 2'-5'-oligoadenylate synthetase-like 2.45905
C1GALT1C1 C1GALT1-specific chaperone 1 2.4557
SLC35E2B solute carrier family 35, member E2B 2.4476
LAPTM4B lysosomal protein transmembrane 4 beta 2.44503
HOXD11 homeobox D11 2.4403
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.43965
MANEA mannosidase, endo-alpha 2.439
TNIP3 TNFAIP3 interacting protein 3 2.4371
UBAP2 ubiquitin associated protein 2 2.43235
TBPL1 TBP-like 1 2.4257
UTF1 undifferentiated embryonic cell transcription factor 1 2.4242
SERINC5 serine incorporator 5 2.4161
PNOC prepronociceptin 2.4152
GUF1 GUF1 GTPase homolog (S. cerevisiae) 2.4084
PLPPR1 phospholipid phosphatase related 1 2.4063
PDLIM1 PDZ and LIM domain 1 2.4032
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.4022
AQP1 aquaporin 1 (Colton blood group) 2.3954
CTSO cathepsin O 2.394
RBP1 retinol binding protein 1, cellular 2.3925
SNX16 sorting nexin 16 2.3918
TRIP12 thyroid hormone receptor interactor 12 2.3909
CLDN1 claudin 1 2.3907
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.3895
BTN1A1 butyrophilin, subfamily 1, member A1 2.3891
RWDD2B RWD domain containing 2B 2.3874
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 2.38323
HHAT hedgehog acyltransferase 2.3826
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.3792
ADAR adenosine deaminase, RNA-specific 2.3723
UGP2 UDP-glucose pyrophosphorylase 2 2.3673
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.3665
TERF2 telomeric repeat binding factor 2 2.3607
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.3583
RPL10A ribosomal protein L10a 2.355
SCTR secretin receptor 2.3277
MUC4 mucin 4, cell surface associated 2.31985
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.31075
FOXJ3 forkhead box J3 2.30875
SRBD1 S1 RNA binding domain 1 2.3074
CHEK1 checkpoint kinase 1 2.3053
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.30515
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 2.30307
CHGB chromogranin B 2.299
ANKEF1 ankyrin repeat and EF-hand domain containing 1 2.299
VWF von Willebrand factor 2.2956
CORO7-PAM16 CORO7-PAM16 readthrough 2.2955
UNC13B unc-13 homolog B (C. elegans) 2.2813
LRRC23 leucine rich repeat containing 23 2.2787
TSGA10 testis specific, 10 2.2765
FMNL1 formin-like 1 2.2724
IRF2 interferon regulatory factor 2 2.2721
OLFML3 olfactomedin-like 3 2.2657
APLP1 amyloid beta (A4) precursor-like protein 1 2.2592
RPL10L ribosomal protein L10-like 2.2541
CLCC1 chloride channel CLIC-like 1 2.2523
CCRL2 chemokine (C-C motif) receptor-like 2 2.2467
CD47 CD47 molecule 2.24383
PIERCE1 piercer of microtubule wall 1 2.2422
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.23745
LCT lactase 2.2327
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.22982
LINS1 lines homolog 1 2.2289
IRF1 interferon regulatory factor 1 2.2285
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.2285
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.2268
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.2261
MYH10 myosin, heavy chain 10, non-muscle 2.22445
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.2121
PCBP1 poly(rC) binding protein 1 2.2102
LRRC20 leucine rich repeat containing 20 2.2098
SUB1 SUB1 homolog (S. cerevisiae) 2.20977
TPH1 tryptophan hydroxylase 1 2.2088
ELP4 elongator acetyltransferase complex subunit 4 2.2061
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.20543
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.2053
PALMD palmdelphin 2.2045
MSANTD3-TMEFF1 MSANTD3-TMEFF1 readthrough 2.20395
EIF5A2 eukaryotic translation initiation factor 5A2 2.2
RSAD2 radical S-adenosyl methionine domain containing 2 2.1989
STAC SH3 and cysteine rich domain 2.1982
PRR5L proline rich 5 like 2.1982
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.1929
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.1926
STN1 STN1 subunit of CST complex 2.1919
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 2.19
KCTD14 potassium channel tetramerization domain containing 14 2.18865
SLPI secretory leukocyte peptidase inhibitor 2.18615
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.1825
TTC19 tetratricopeptide repeat domain 19 2.1822
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 2.1811
HSPB8 heat shock 22kDa protein 8 2.1774
RBMS1 RNA binding motif, single stranded interacting protein 1 2.17018
SCHIP1 schwannomin interacting protein 1 2.1701
SPA17 sperm autoantigenic protein 17 2.1699
LYPD1 LY6/PLAUR domain containing 1 2.1694
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.1678
ACTA2 actin, alpha 2, smooth muscle, aorta 2.1662
ATP9A ATPase, class II, type 9A 2.1659
ATXN7L1 ataxin 7-like 1 2.1647
MXRA7 matrix-remodelling associated 7 2.163
TPPP tubulin polymerization promoting protein 2.1591
H2AZ2 H2A.Z variant histone 2 2.15897
ANXA4 annexin A4 2.15175
KAT6B K(lysine) acetyltransferase 6B 2.1508
CBY1 chibby homolog 1 (Drosophila) 2.1504
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.1486
MYT1L myelin transcription factor 1-like 2.14755
TMEM38B transmembrane protein 38B 2.1451
STATH statherin 2.1445
ACE2 angiotensin I converting enzyme 2 2.13705
VEGFD vascular endothelial growth factor D 2.1369
SRR serine racemase 2.135
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.1323
SOX17 SRY (sex determining region Y)-box 17 2.1317
XPO4 exportin 4 2.1259
PLP1 proteolipid protein 1 2.1241
CD38 CD38 molecule 2.1236
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.1212
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.1199
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.1182
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 2.1134
TAPBPL TAP binding protein-like 2.11323
NDC80 NDC80 kinetochore complex component 2.1094
RNF38 ring finger protein 38 2.1047
HAX1 HCLS1 associated protein X-1 2.1046
MMP7 matrix metallopeptidase 7 2.1033
ATF4 activating transcription factor 4 2.1021
ATP8B4 ATPase, class I, type 8B, member 4 2.0957
NEK7 NIMA-related kinase 7 2.0944
BSN bassoon presynaptic cytomatrix protein 2.0929
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.0927
CENPU centromere protein U 2.0919
PHTF1 putative homeodomain transcription factor 1 2.09183
CTNNBL1 catenin, beta like 1 2.0917
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.0842
TTC9 tetratricopeptide repeat domain 9 2.0841
TEX30 testis expressed 30 2.0837
SOCS1 suppressor of cytokine signaling 1 2.08315
CRIPT cysteine-rich PDZ-binding protein 2.0827
SEPTIN10 septin 10 2.0818
ADD1 adducin 1 (alpha) 2.07967
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.0796
STK10 serine/threonine kinase 10 2.0793
LIM2 lens intrinsic membrane protein 2, 19kDa 2.0791
SMAGP small cell adhesion glycoprotein 2.0784
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.0773
FAT4 FAT atypical cadherin 4 2.0754
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.07197
AGA aspartylglucosaminidase 2.06987
B4GAT1 beta-1,4-glucuronyltransferase 1 2.0671
NFASC neurofascin 2.06455
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.0645
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.0633
GYG1 glycogenin 1 2.0603
SPATA6L spermatogenesis associated 6-like 2.0588
ARID5B AT rich interactive domain 5B (MRF1-like) 2.0575
RPGRIP1L RPGRIP1-like 2.0558
GDAP1 ganglioside induced differentiation associated protein 1 2.0539
ATXN3 ataxin 3 2.0536
ATRNL1 attractin-like 1 2.0523
PDCL phosducin-like 2.05185
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 2.0504
IL10RB interleukin 10 receptor, beta 2.0418
IFNG interferon, gamma 2.0404
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 2.0376
OVGP1 oviductal glycoprotein 1, 120kDa 2.0341
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.0333
ADA2 adenosine deaminase 2 2.0326
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.02973
DND1 DND microRNA-mediated repression inhibitor 1 2.02935
HCRT hypocretin (orexin) neuropeptide precursor 2.0288
C1QB complement component 1, q subcomponent, B chain 2.0283
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.0265
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.0249
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.02155
SRSF7 serine/arginine-rich splicing factor 7 2.0215
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.0201
JOSD1 Josephin domain containing 1 2.0195
PLAAT1 phospholipase A and acyltransferase 1 2.01945
ACTL6B actin-like 6B 2.0192
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.0172
MBNL2 muscleblind-like splicing regulator 2 2.01673
EXOC5 exocyst complex component 5 2.0138
CLDN10 claudin 10 2.0118
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.0116
ITCH itchy E3 ubiquitin protein ligase 2.01093
ANKRD17 ankyrin repeat domain 17 2.0104
ALPG alkaline phosphatase, germ cell 2.01037
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.0094
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 2.00797
SP3 Sp3 transcription factor 2.0076
ASRGL1 asparaginase like 1 2.0066
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 2.0065
GAS2 growth arrest-specific 2 2.0059
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.0048
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 2.00175
LGI1 leucine-rich, glioma inactivated 1 2.0017

decreased expression

Symbol Name Standardized Value
SGK1 serum/glucocorticoid regulated kinase 1 -10.0
TRAPPC3 trafficking protein particle complex 3 -9.62685
COTL1 coactosin-like F-actin binding protein 1 -8.7181
CANT1 calcium activated nucleotidase 1 -8.2775
SNCA synuclein, alpha (non A4 component of amyloid precursor) -7.80545
ACAA1 acetyl-CoA acyltransferase 1 -6.18795
TRIB3 tribbles pseudokinase 3 -5.1628
AGO1 argonaute RISC catalytic component 1 -5.0392
CD81 CD81 molecule -4.7488
CLASRP CLK4-associating serine/arginine rich protein -4.6692
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -4.4804
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -4.3809
ATP11B ATPase, class VI, type 11B -4.2835
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -4.1462
RABL6 RAB, member RAS oncogene family-like 6 -3.9579
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -3.90145
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -3.8952
ALAS2 5'-aminolevulinate synthase 2 -3.8458
MMP9 matrix metallopeptidase 9 -3.807
PRPF19 pre-mRNA processing factor 19 -3.7834
MRPS15 mitochondrial ribosomal protein S15 -3.765
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -3.7124
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -3.6384
MEAF6 MYST/Esa1-associated factor 6 -3.6278
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -3.57615
SF3A3 splicing factor 3a, subunit 3, 60kDa -3.5639
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide -3.5546
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -3.5458
DIO3 deiodinase, iodothyronine, type III -3.5342
KCTD7 potassium channel tetramerization domain containing 7 -3.5281
MAP7D1 MAP7 domain containing 1 -3.5136
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -3.4825
TMEM132A transmembrane protein 132A -3.4798
CLUH clustered mitochondria (cluA/CLU1) homolog -3.4793
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -3.4349
COL8A2 collagen, type VIII, alpha 2 -3.42195
BCAS4 breast carcinoma amplified sequence 4 -3.3735
CDK14 cyclin-dependent kinase 14 -3.37225
PDIA3 protein disulfide isomerase family A, member 3 -3.3606
IGF2R insulin-like growth factor 2 receptor -3.3273
SDF2L1 stromal cell-derived factor 2-like 1 -3.3185
FGL1 fibrinogen-like 1 -3.2812
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -3.2471
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -3.2288
CXCR5 chemokine (C-X-C motif) receptor 5 -3.22645
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -3.1894
FBN2 fibrillin 2 -3.1813
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -3.1765
TCL1A T-cell leukemia/lymphoma 1A -3.15635
RBM15B RNA binding motif protein 15B -3.1327
PHC2 polyhomeotic homolog 2 (Drosophila) -3.1054
TYR tyrosinase -3.1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -3.0901
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -3.083
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -3.07
YBX3 Y box binding protein 3 -3.0591
CHMP7 charged multivesicular body protein 7 -3.0241
ZMYM4 zinc finger, MYM-type 4 -3.02043
BCL6 B-cell CLL/lymphoma 6 -2.9938
ADAM15 ADAM metallopeptidase domain 15 -2.9666
LPXN leupaxin -2.9505
KIFC1 kinesin family member C1 -2.9474
HBG1 hemoglobin, gamma A -2.94613
LOC102724594 splicing factor U2AF 35 kDa subunit -2.9377
AK2 adenylate kinase 2 -2.92862
PTPRK protein tyrosine phosphatase, receptor type, K -2.9264
LAMB3 laminin, beta 3 -2.9249
BLNK B-cell linker -2.9141
AGO4 argonaute RISC catalytic component 4 -2.9118
RWDD3 RWD domain containing 3 -2.9069
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.9048
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.8809
MAVS mitochondrial antiviral signaling protein -2.8732
NCF1 neutrophil cytosolic factor 1 -2.86015
IRF8 interferon regulatory factor 8 -2.8574
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -2.84935
BTG1 B-cell translocation gene 1, anti-proliferative -2.8456
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.8451
PRR16 proline rich 16 -2.8435
FARSA phenylalanyl-tRNA synthetase, alpha subunit -2.83735
EPB42 erythrocyte membrane protein band 4.2 -2.8236
BANK1 B-cell scaffold protein with ankyrin repeats 1 -2.8234
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -2.81017
PSEN2 presenilin 2 -2.80863
F5 coagulation factor V (proaccelerin, labile factor) -2.80505
STX7 syntaxin 7 -2.7971
COL11A2 collagen, type XI, alpha 2 -2.7931
ZNF768 zinc finger protein 768 -2.7861
MTARC2 mitochondrial amidoxime reducing component 2 -2.78505
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.7594
PFDN6 prefoldin subunit 6 -2.75765
MUC13 mucin 13, cell surface associated -2.7541
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -2.7514
EREG epiregulin -2.7437
CD1C CD1c molecule -2.743
INPP5B inositol polyphosphate-5-phosphatase, 75kDa -2.7363
CDCA8 cell division cycle associated 8 -2.7126
R3HDM4 R3H domain containing 4 -2.7114
TMED9 transmembrane emp24 protein transport domain containing 9 -2.7098
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.7084
ZNF629 zinc finger protein 629 -2.7083
KRT8 keratin 8, type II -2.7066
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -2.7054
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.70375
TEX2 testis expressed 2 -2.6932
TMEM70 transmembrane protein 70 -2.6915
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.6902
SOX9 SRY (sex determining region Y)-box 9 -2.68385
RAB35 RAB35, member RAS oncogene family -2.6832
EVA1B eva-1 homolog B (C. elegans) -2.67975
POM121 POM121 transmembrane nucleoporin -2.6727
ACP2 acid phosphatase 2, lysosomal -2.6648
ZBTB22 zinc finger and BTB domain containing 22 -2.6553
HIRA histone cell cycle regulator -2.6522
CLPTM1 cleft lip and palate associated transmembrane protein 1 -2.63255
EFNA4 ephrin-A4 -2.6316
FAM50B family with sequence similarity 50, member B -2.6292
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.6167
TTC17 tetratricopeptide repeat domain 17 -2.6123
TBC1D13 TBC1 domain family, member 13 -2.61135
CHPF2 chondroitin polymerizing factor 2 -2.6111
PRDM4 PR domain containing 4 -2.6092
FAM110B family with sequence similarity 110, member B -2.6048
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 -2.5922
FUS FUS RNA binding protein -2.59055
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.58685
NSD1 nuclear receptor binding SET domain protein 1 -2.5816
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.5815
ELL3 elongation factor RNA polymerase II-like 3 -2.57735
LMNB1 lamin B1 -2.5712
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -2.5667
CRYBB2 crystallin, beta B2 -2.56325
GTF2IRD1 GTF2I repeat domain containing 1 -2.563
CXCR1 chemokine (C-X-C motif) receptor 1 -2.5608
PLEK2 pleckstrin 2 -2.5605
TRAK1 trafficking protein, kinesin binding 1 -2.551
INPPL1 inositol polyphosphate phosphatase-like 1 -2.5449
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -2.5433
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.54005
LCK LCK proto-oncogene, Src family tyrosine kinase -2.5286
CCNDBP1 cyclin D-type binding-protein 1 -2.5211
FGB fibrinogen beta chain -2.51945
NCBP3 nuclear cap binding subunit 3 -2.5153
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.5077
KLK12 kallikrein-related peptidase 12 -2.5061
CMTR1 cap methyltransferase 1 -2.5055
KDM8 lysine (K)-specific demethylase 8 -2.4992
MEX3C mex-3 RNA binding family member C -2.4974
TSG101 tumor susceptibility 101 -2.494
SLC12A9 solute carrier family 12, member 9 -2.4771
AGO3 argonaute RISC catalytic component 3 -2.46235
TNS4 tensin 4 -2.4614
AHSP alpha hemoglobin stabilizing protein -2.456
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -2.455
EPHB4 EPH receptor B4 -2.4538
DUSP14 dual specificity phosphatase 14 -2.4537
PFN2 profilin 2 -2.4472
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.4463
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -2.4406
ADGRE3 adhesion G protein-coupled receptor E3 -2.4309
JMJD7 jumonji domain containing 7 -2.4237
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.4227
KLHL22 kelch-like family member 22 -2.42187
CD79B CD79b molecule, immunoglobulin-associated beta -2.4218
MAGEA9B melanoma antigen family A9B -2.4186
NRBF2 nuclear receptor binding factor 2 -2.4104
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.4069
HMGA2 high mobility group AT-hook 2 -2.4046
GAR1 GAR1 ribonucleoprotein -2.4041
OFD1 oral-facial-digital syndrome 1 -2.3949
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.392
CD69 CD69 molecule -2.3901
LMO4 LIM domain only 4 -2.38775
ELOVL4 ELOVL fatty acid elongase 4 -2.3868
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 -2.3832
LONP2 lon peptidase 2, peroxisomal -2.37745
BPGM 2,3-bisphosphoglycerate mutase -2.376
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.3754
DMAC2 distal membrane arm assembly component 2 -2.3717
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.3714
TTC4 tetratricopeptide repeat domain 4 -2.36615
PRAME preferentially expressed antigen in melanoma -2.3648
LMO1 LIM domain only 1 (rhombotin 1) -2.364
GLRX5 glutaredoxin 5 -2.3616
NADK NAD kinase -2.35894
IGSF3 immunoglobulin superfamily, member 3 -2.3569
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.3443
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.3442
HOXC11 homeobox C11 -2.3423
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.3384
TRAFD1 TRAF-type zinc finger domain containing 1 -2.33805
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -2.33485
SCAP SREBF chaperone -2.3276
PHF21A PHD finger protein 21A -2.3268
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 -2.32517
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.3186
PLEK pleckstrin -2.31075
FKBP10 FK506 binding protein 10, 65 kDa -2.3094
SGSH N-sulfoglucosamine sulfohydrolase -2.3089
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.307
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -2.2985
BCOR BCL6 corepressor -2.2982
CDA cytidine deaminase -2.2917
FGA fibrinogen alpha chain -2.285
SH2D4A SH2 domain containing 4A -2.2827
TFF2 trefoil factor 2 -2.2813
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -2.2797
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.273
ZNF91 zinc finger protein 91 -2.2723
LTB lymphotoxin beta (TNF superfamily, member 3) -2.2711
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.2706
APMAP adipocyte plasma membrane associated protein -2.2582
TRPS1 trichorhinophalangeal syndrome I -2.2573
MANF mesencephalic astrocyte-derived neurotrophic factor -2.2545
LARP6 La ribonucleoprotein domain family, member 6 -2.2534
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.25333
PRR13 proline rich 13 -2.2516
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.2503
INPP5J inositol polyphosphate-5-phosphatase J -2.2498
MNMIP1 manchette microtubule inner protein 1 -2.2387
DDB1 damage-specific DNA binding protein 1, 127kDa -2.2373
NUP153 nucleoporin 153kDa -2.2356
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.23545
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.2322
ZNF668 zinc finger protein 668 -2.2278
DAPK3 death-associated protein kinase 3 -2.2274
ADGRE2 adhesion G protein-coupled receptor E2 -2.2268
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.2206
CACFD1 calcium channel flower domain containing 1 -2.21645
CNTNAP1 contactin associated protein 1 -2.2155
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.1993
CD83 CD83 molecule -2.1941
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.1911
FECH ferrochelatase -2.18925
PRELID3A PRELI domain containing 3A -2.1892
CTSF cathepsin F -2.1888
SETD1A SET domain containing 1A -2.1818
ZNF692 zinc finger protein 692 -2.1806
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.17485
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -2.1711
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.1646
AKIRIN1 akirin 1 -2.1581
TAGLN2 transgelin 2 -2.15725
LYST lysosomal trafficking regulator -2.15583
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.1545
RGS18 regulator of G-protein signaling 18 -2.1537
VCAM1 vascular cell adhesion molecule 1 -2.1536
COL9A2 collagen, type IX, alpha 2 -2.1534
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.1504
ZNF444 zinc finger protein 444 -2.15005
KIAA0319L KIAA0319-like -2.1477
GYPB glycophorin B (MNS blood group) -2.1473
CCNG2 cyclin G2 -2.14467
BORCS8 BLOC-1 related complex subunit 8 -2.1405
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -2.1399
ZNF354A zinc finger protein 354A -2.1398
PRSS21 protease, serine, 21 (testisin) -2.1393
CLIP2 CAP-GLY domain containing linker protein 2 -2.1342
BICRA BRD4 interacting chromatin remodeling complex associated protein -2.1339
TEDC2 tubulin epsilon and delta complex 2 -2.1313
SHTN1 shootin 1 -2.1295
TYRP1 tyrosinase-related protein 1 -2.1265
MMP14 matrix metallopeptidase 14 (membrane-inserted) -2.12547
TFCP2 transcription factor CP2 -2.12485
SLC43A3 solute carrier family 43, member 3 -2.12345
ZNF324 zinc finger protein 324 -2.1191
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.1185
CCN3 cellular communication network factor 3 -2.1179
ZC2HC1A zinc finger, C2HC-type containing 1A -2.1155
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.1153
RANGAP1 Ran GTPase activating protein 1 -2.11525
ZNF136 zinc finger protein 136 -2.1123
FIG4 FIG4 phosphoinositide 5-phosphatase -2.1087
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.1075
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.107
CEP131 centrosomal protein 131kDa -2.1045
MRM3 mitochondrial rRNA methyltransferase 3 -2.0989
ZNF804A zinc finger protein 804A -2.0908
PGAP3 post-GPI attachment to proteins 3 -2.09065
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -2.085
KLF4 Kruppel-like factor 4 (gut) -2.0845
MPPE1 metallophosphoesterase 1 -2.08153
TMEM39A transmembrane protein 39A -2.0783
CERS2 ceramide synthase 2 -2.0773
UROD uroporphyrinogen decarboxylase -2.07687
ZDHHC18 zinc finger, DHHC-type containing 18 -2.0749
IPP intracisternal A particle-promoted polypeptide -2.074
RSAD1 radical S-adenosyl methionine domain containing 1 -2.0705
SREK1IP1 SREK1-interacting protein 1 -2.0699
GCC1 GRIP and coiled-coil domain containing 1 -2.0672
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -2.0659
SIAH1 siah E3 ubiquitin protein ligase 1 -2.0617
SYMPK symplekin -2.0609
ZNF226 zinc finger protein 226 -2.059
ZFYVE9 zinc finger, FYVE domain containing 9 -2.0586
MYL4 myosin, light chain 4, alkali; atrial, embryonic -2.05613
GSK3B glycogen synthase kinase 3 beta -2.0535
FZD2 frizzled class receptor 2 -2.0523
TRAF4 TNF receptor-associated factor 4 -2.05145
FBXO41 F-box protein 41 -2.0468
SEPHS2 selenophosphate synthetase 2 -2.0455
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.04483
TAC3 tachykinin 3 -2.0441
DGCR2 DiGeorge syndrome critical region gene 2 -2.04165
U2AF2 U2 small nuclear RNA auxiliary factor 2 -2.0405
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.0398
CSPG4 chondroitin sulfate proteoglycan 4 -2.0354
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 -2.0347
TSSC4 tumor suppressing subtransferable candidate 4 -2.0313
SOBP sine oculis binding protein homolog (Drosophila) -2.0299
MSL1 male-specific lethal 1 homolog (Drosophila) -2.0286
SPRING1 SREBF pathway regulator in golgi 1 -2.0239
ACADVL acyl-CoA dehydrogenase, very long chain -2.0229
GDF5 growth differentiation factor 5 -2.0177
PLAGL1 pleiomorphic adenoma gene-like 1 -2.0163
ZNF783 zinc finger family member 783 -2.0161
GPR137B G protein-coupled receptor 137B -2.0116
ATG101 autophagy related 101 -2.009
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.0031