CRCGN015_MCF10A.TP53.M_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1h-1,2,3-benzotriazole 11.2 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

186 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 8.71683
EPHB2 EPH receptor B2 6.57028
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.7976
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 3.32595
MCOLN1 mucolipin 1 3.3034
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.0985
CSK c-src tyrosine kinase 2.9468
RARS1 arginyl-tRNA synthetase 1 2.8965
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.8403
SLIT2 slit homolog 2 (Drosophila) 2.7455
PMVK phosphomevalonate kinase 2.7035
MECR mitochondrial trans-2-enoyl-CoA reductase 2.6697
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.5963
BEX3 brain expressed X-linked 3 2.5868
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.5752
GDF2 growth differentiation factor 2 2.5743
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.5661
CSNK1A1 casein kinase 1, alpha 1 2.5376
BBC3 BCL2 binding component 3 2.5309
BRD9 bromodomain containing 9 2.5232
DOHH deoxyhypusine hydroxylase/monooxygenase 2.5027
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.495
KIFC3 kinesin family member C3 2.4862
YARS1 tyrosyl-tRNA synthetase 1 2.4836
MANEA mannosidase, endo-alpha 2.4734
WDR41 WD repeat domain 41 2.4555
RINT1 RAD50 interactor 1 2.4479
TCEAL9 transcription elongation factor A like 9 2.401
ALS2CL ALS2 C-terminal like 2.3525
LIMA1 LIM domain and actin binding 1 2.35
CIRBP cold inducible RNA binding protein 2.3437
KIF1B kinesin family member 1B 2.3366
STAP2 signal transducing adaptor family member 2 2.3337
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.3095
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.30855
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 2.3083
A4GALT alpha 1,4-galactosyltransferase 2.2967
FPGT fucose-1-phosphate guanylyltransferase 2.2574
PECR peroxisomal trans-2-enoyl-CoA reductase 2.2416
ALX1 ALX homeobox 1 2.2299
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 2.22875
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.225
DUX4 double homeobox 4 2.2244
MRPS2 mitochondrial ribosomal protein S2 2.2056
ERI3 ERI1 exoribonuclease family member 3 2.2023
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.1923
SLC75A1 solute carrier family 75 member 1 2.1847
LYRM1 LYR motif containing 1 2.1792
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 2.175
HEBP1 heme binding protein 1 2.1619
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.15915
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.1575
LYPD1 LY6/PLAUR domain containing 1 2.1458
GTF2IRD1 GTF2I repeat domain containing 1 2.1365
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.1326
HRAS Harvey rat sarcoma viral oncogene homolog 2.1274
ELP4 elongator acetyltransferase complex subunit 4 2.1136
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.1085
SZRD1 SUZ RNA binding domain containing 1 2.10322
WNT10B wingless-type MMTV integration site family, member 10B 2.1017
AAMP angio-associated, migratory cell protein 2.097
ZNF747 zinc finger protein 747 2.0964
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.0808
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 2.0785
BCAP29 B-cell receptor-associated protein 29 2.0742
FUS FUS RNA binding protein 2.06685
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.05565
SETD1B SET domain containing 1B 2.0524
MACROH2A2 macroH2A.2 histone 2.0517
SRP54 signal recognition particle 54kDa 2.0505
DCTPP1 dCTP pyrophosphatase 1 2.0491
ISOC2 isochorismatase domain containing 2 2.0439
NOSIP nitric oxide synthase interacting protein 2.0357
THAP11 THAP domain containing 11 2.032
LYPD3 LY6/PLAUR domain containing 3 2.0293
MTG1 mitochondrial ribosome-associated GTPase 1 2.0219
INPPL1 inositol polyphosphate phosphatase-like 1 2.02
ADIPOR2 adiponectin receptor 2 2.0197
CHMP1A charged multivesicular body protein 1A 2.0195
FPGS folylpolyglutamate synthase 2.0172
MRTFB myocardin related transcription factor B 2.013
CCDC47 coiled-coil domain containing 47 2.0081
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.00353
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 2.0

decreased expression

Symbol Name Standardized Value
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -6.87677
NLRP4 NLR family, pyrin domain containing 4 -6.4467
NGRN neugrin, neurite outgrowth associated -5.3568
ACAA1 acetyl-CoA acyltransferase 1 -5.3414
CRTAP cartilage associated protein -5.0702
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.8257
TUBA4A tubulin, alpha 4a -3.8399
ATP5F1E ATP synthase F1 subunit epsilon -3.8308
ACOT9 acyl-CoA thioesterase 9 -3.715
SEC61G Sec61 gamma subunit -3.6745
MRPS17 mitochondrial ribosomal protein S17 -3.4478
TSPAN3 tetraspanin 3 -3.4117
CRY2 cryptochrome circadian clock 2 -3.3753
C1QBP complement component 1, q subcomponent binding protein -3.37275
DUSP14 dual specificity phosphatase 14 -3.3485
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -3.0956
SNRPE small nuclear ribonucleoprotein polypeptide E -3.0604
AVL9 AVL9 homolog (S. cerevisiase) -2.9972
GGCT gamma-glutamylcyclotransferase -2.9682
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.8907
CFP complement factor properdin -2.8824
DGKA diacylglycerol kinase, alpha 80kDa -2.8558
VAMP5 vesicle-associated membrane protein 5 -2.8084
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.8034
COX7C cytochrome c oxidase subunit VIIc -2.8022
USP6NL USP6 N-terminal like -2.7996
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.7777
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.73105
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.7299
NRIP3 nuclear receptor interacting protein 3 -2.6773
F5 coagulation factor V (proaccelerin, labile factor) -2.58825
CYTL1 cytokine-like 1 -2.5401
FANCI Fanconi anemia, complementation group I -2.53675
CALML4 calmodulin-like 4 -2.524
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.5184
ZNF510 zinc finger protein 510 -2.5082
CEP192 centrosomal protein 192kDa -2.4928
IL16 interleukin 16 -2.45485
BCL2L13 BCL2-like 13 (apoptosis facilitator) -2.4421
BTK Bruton agammaglobulinemia tyrosine kinase -2.4336
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.4203
MCTS1 malignant T cell amplified sequence 1 -2.4179
ATXN7 ataxin 7 -2.4055
EFNA4 ephrin-A4 -2.405
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.3903
IFFO1 intermediate filament family orphan 1 -2.38875
REV1 REV1, polymerase (DNA directed) -2.3845
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.3343
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -2.3319
RPS27L ribosomal protein S27-like -2.3223
RWDD3 RWD domain containing 3 -2.3192
CD200 CD200 molecule -2.31905
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.3093
PRC1 protein regulator of cytokinesis 1 -2.297
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.2904
ZC3H7A zinc finger CCCH-type containing 7A -2.2868
FNDC3B fibronectin type III domain containing 3B -2.2806
SNRPG small nuclear ribonucleoprotein polypeptide G -2.2716
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.26795
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.26267
FLT3 fms-related tyrosine kinase 3 -2.2595
UBE2C ubiquitin-conjugating enzyme E2C -2.2543
DCLRE1C DNA cross-link repair 1C -2.245
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.2398
HINT1 histidine triad nucleotide binding protein 1 -2.23357
CCN2 cellular communication network factor 2 -2.2276
FES FES proto-oncogene, tyrosine kinase -2.2276
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.2202
MANBA mannosidase, beta A, lysosomal -2.2201
TP53RK TP53 regulating kinase -2.2092
SNRPF small nuclear ribonucleoprotein polypeptide F -2.2056
ATP5PD ATP synthase peripheral stalk subunit d -2.2043
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.196
MATN2 matrilin 2 -2.1879
HMG20A high mobility group 20A -2.1714
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.1579
POPDC2 popeye domain containing 2 -2.1431
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -2.13735
TBCA tubulin folding cofactor A -2.1163
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.114
CRYAB crystallin, alpha B -2.0998
FAN1 FANCD2/FANCI-associated nuclease 1 -2.0937
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.0933
XPOT exportin, tRNA -2.0791
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.0672
STX16 syntaxin 16 -2.066
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 -2.0599
TGIF1 TGFB-induced factor homeobox 1 -2.0573
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.0558
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.0532
SLC44A1 solute carrier family 44 (choline transporter), member 1 -2.0414
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -2.0397
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.03327
CTSH cathepsin H -2.0277
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -2.027
KLHL36 kelch-like family member 36 -2.021
EFS embryonal Fyn-associated substrate -2.0198
SAP30BP SAP30 binding protein -2.019
THEMIS2 thymocyte selection associated family member 2 -2.0149
DOCK2 dedicator of cytokinesis 2 -2.0142
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.0102
CIDEB cell death-inducing DFFA-like effector b -2.0073