CRCGN015_MCF10A.TP53.M_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

185 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 8.55319
AGR2 anterior gradient 2 7.75305
PYCR1 pyrroline-5-carboxylate reductase 1 7.30065
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.92524
AARS1 alanyl-tRNA synthetase 1 5.1909
ALAS1 5'-aminolevulinate synthase 1 4.76877
PHGDH phosphoglycerate dehydrogenase 4.57154
NUCB2 nucleobindin 2 4.54686
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.07092
ASNS asparagine synthetase (glutamine-hydrolyzing) 4.03794
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.03731
TCEA2 transcription elongation factor A (SII), 2 3.93584
SNAP25 synaptosomal-associated protein, 25kDa 3.82145
SPAG4 sperm associated antigen 4 3.54719
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.48125
TMEM109 transmembrane protein 109 3.44684
GARS1 glycyl-tRNA synthetase 1 3.4202
RBKS ribokinase 3.30626
PRAF2 PRA1 domain family, member 2 3.30507
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.26847
HOXA5 homeobox A5 3.23948
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.22316
PNKP polynucleotide kinase 3'-phosphatase 3.17737
SKIC2 SKI2 subunit of superkiller complex 2.90647
NRIP1 nuclear receptor interacting protein 1 2.89442
GLRX glutaredoxin (thioltransferase) 2.87088
FHL2 four and a half LIM domains 2 2.83599
MYLK myosin light chain kinase 2.82833
GATA3 GATA binding protein 3 2.82106
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.74295
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.66127
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.5778
SCCPDH saccharopine dehydrogenase (putative) 2.51142
STAMBP STAM binding protein 2.50879
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.4972
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.48881
KDM5A lysine (K)-specific demethylase 5A 2.48341
IER3 immediate early response 3 2.47824
PSAT1 phosphoserine aminotransferase 1 2.46421
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.41641
GATA2 GATA binding protein 2 2.40121
CARMIL1 capping protein regulator and myosin 1 linker 1 2.39722
DUSP4 dual specificity phosphatase 4 2.38972
SETD5 SET domain containing 5 2.37572
CALU calumenin 2.36902
SLC35B1 solute carrier family 35, member B1 2.36609
CREB1 cAMP responsive element binding protein 1 2.31927
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.29145
SYT1 synaptotagmin I 2.28685
YARS1 tyrosyl-tRNA synthetase 1 2.27746
ETFB electron-transfer-flavoprotein, beta polypeptide 2.24721
AFTPH aftiphilin 2.24166
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.24151
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2.21147
BEX2 brain expressed X-linked 2 2.20437
TSKU tsukushi, small leucine rich proteoglycan 2.19965
GRB10 growth factor receptor-bound protein 10 2.18333
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.17666
NAV3 neuron navigator 3 2.17099
LOC128125814 uncharacterized LOC128125814 2.16308
ATXN2 ataxin 2 2.15965
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.14506
HDLBP high density lipoprotein binding protein 2.1399
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.12396
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.12244
MARS1 methionyl-tRNA synthetase 1 2.12078
HMGA2 high mobility group AT-hook 2 2.08876
FYN FYN proto-oncogene, Src family tyrosine kinase 2.0803
XPOT exportin, tRNA 2.07662
LOC102724560 cystathionine beta-synthase 2.06245
GLI3 GLI family zinc finger 3 2.06073
STMN2 stathmin 2 2.05425
ACADVL acyl-CoA dehydrogenase, very long chain 2.03872
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.03827
CCDC85B coiled-coil domain containing 85B 2.03537
TRAK2 trafficking protein, kinesin binding 2 2.01283
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.00781
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.00425

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.09856
ANKRD10 ankyrin repeat domain 10 -4.86808
HAT1 histone acetyltransferase 1 -4.35471
CCNB2 cyclin B2 -4.17085
ADRB2 adrenoceptor beta 2, surface -4.08955
MRPS2 mitochondrial ribosomal protein S2 -3.95858
DCK deoxycytidine kinase -3.84458
PUF60 poly-U binding splicing factor 60KDa -3.70659
STMN1 stathmin 1 -3.69926
KIF20A kinesin family member 20A -3.68995
ACOT9 acyl-CoA thioesterase 9 -3.51552
INSIG1 insulin induced gene 1 -3.50031
KRT14 keratin 14, type I -3.47258
HMG20B high mobility group 20B -3.44028
CDK1 cyclin-dependent kinase 1 -3.42268
LAP3 leucine aminopeptidase 3 -3.371
ADI1 acireductone dioxygenase 1 -3.36594
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.34875
PLK1 polo-like kinase 1 -3.27637
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.21199
SCARB1 scavenger receptor class B, member 1 -3.18137
C1QBP complement component 1, q subcomponent binding protein -3.07103
RBM34 RNA binding motif protein 34 -3.06261
ERCC6L excision repair cross-complementation group 6-like -3.02038
UBE3C ubiquitin protein ligase E3C -2.97875
ATF5 activating transcription factor 5 -2.97724
PARPBP PARP1 binding protein -2.9272
AURKA aurora kinase A -2.83021
FASTKD5 FAST kinase domains 5 -2.81803
PFN1 profilin 1 -2.80385
NEK2 NIMA-related kinase 2 -2.76087
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.70754
POLR1F RNA polymerase I subunit F -2.68008
FPGS folylpolyglutamate synthase -2.67824
R3HCC1L R3H domain and coiled-coil containing 1-like -2.6651
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.6615
CCNF cyclin F -2.64526
YJU2 YJU2 splicing factor homolog -2.62529
SOAT2 sterol O-acyltransferase 2 -2.58647
CYCS cytochrome c, somatic -2.5671
KIF14 kinesin family member 14 -2.56299
MSMO1 methylsterol monooxygenase 1 -2.55814
TXNDC9 thioredoxin domain containing 9 -2.51788
DEPDC1 DEP domain containing 1 -2.51238
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.49825
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.46694
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.46504
GRWD1 glutamate-rich WD repeat containing 1 -2.44771
PSRC1 proline/serine-rich coiled-coil 1 -2.44397
NUSAP1 nucleolar and spindle associated protein 1 -2.42264
ZNF35 zinc finger protein 35 -2.40175
CCNA2 cyclin A2 -2.39543
KIF4A kinesin family member 4A -2.37824
SAP30L SAP30-like -2.36437
SH3D19 SH3 domain containing 19 -2.3543
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.34421
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.33543
TUBB4B tubulin, beta 4B class IVb -2.33478
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.32868
BIRC5 baculoviral IAP repeat containing 5 -2.3107
UBE2C ubiquitin-conjugating enzyme E2C -2.30504
ARMH3 armadillo like helical domain containing 3 -2.29311
NOTCH1 notch 1 -2.29223
FANCC Fanconi anemia, complementation group C -2.27492
SMNDC1 survival motor neuron domain containing 1 -2.26333
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.24814
BCL7B B-cell CLL/lymphoma 7B -2.24239
MRPL44 mitochondrial ribosomal protein L44 -2.23994
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.2358
MTMR12 myotubularin related protein 12 -2.2143
KIF23 kinesin family member 23 -2.20592
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.2059
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.20227
CCDC198 coiled-coil domain containing 198 -2.20107
SPC25 SPC25, NDC80 kinetochore complex component -2.199
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.19674
ADGRE5 adhesion G protein-coupled receptor E5 -2.18256
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.17507
CDCA3 cell division cycle associated 3 -2.17212
ARHGAP11A Rho GTPase activating protein 11A -2.16926
PDCL3 phosducin-like 3 -2.16316
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.14812
FLT4 fms-related tyrosine kinase 4 -2.14604
GPR176 G protein-coupled receptor 176 -2.13635
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.12128
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.10623
SGK1 serum/glucocorticoid regulated kinase 1 -2.09644
CCN3 cellular communication network factor 3 -2.08875
GJB5 gap junction protein, beta 5, 31.1kDa -2.08588
RABL6 RAB, member RAS oncogene family-like 6 -2.08435
IRX4 iroquois homeobox 4 -2.08249
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.07901
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -2.07425
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.07171
CENPI centromere protein I -2.06051
MCMBP minichromosome maintenance complex binding protein -2.05824
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -2.0573
PRR15L proline rich 15-like -2.05555
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.04559
SLC61A1 solute carrier family 61 member 1 -2.04297
FOXN2 forkhead box N2 -2.02444
ADNP2 ADNP homeobox 2 -2.02281
ACADL acyl-CoA dehydrogenase, long chain -2.01661
PSIP1 PC4 and SFRS1 interacting protein 1 -2.01452
OIP5 Opa interacting protein 5 -2.00931
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 -2.00273
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.00197