CRCGN015_MCF10A.TP53.M_24H:G03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 11.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 4.14639
TIAM1 T-cell lymphoma invasion and metastasis 1 3.63974
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.63868
VAV3 vav 3 guanine nucleotide exchange factor 3.58674
AGR2 anterior gradient 2 2.87893
FGFR4 fibroblast growth factor receptor 4 2.84126
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.83078
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.76085
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.60001
ADGRE5 adhesion G protein-coupled receptor E5 2.58392
ANO10 anoctamin 10 2.46748
WIF1 WNT inhibitory factor 1 2.39004
VGLL4 vestigial-like family member 4 2.3535
SKIC8 SKI8 subunit of superkiller complex 2.34819
IGFBP3 insulin-like growth factor binding protein 3 2.28393
CERK ceramide kinase 2.27597
CCL2 chemokine (C-C motif) ligand 2 2.14022
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.02817
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 2.02643

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -3.99652
GRN granulin -3.87684
TES testin LIM domain protein -3.44452
TIMP1 TIMP metallopeptidase inhibitor 1 -3.32922
CSRP1 cysteine and glycine-rich protein 1 -3.19897
NPDC1 neural proliferation, differentiation and control, 1 -2.86235
PTK2 protein tyrosine kinase 2 -2.49996
NLRP4 NLR family, pyrin domain containing 4 -2.34675
MRPL58 mitochondrial ribosomal protein L58 -2.23936
ARMC7 armadillo repeat containing 7 -2.12072
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.04121