CRCGN015_MCF10A.TP53.M_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloroacetophenone 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 5.6159
PPARG peroxisome proliferator-activated receptor gamma 5.21905
WFS1 Wolfram syndrome 1 (wolframin) 4.95775
STK10 serine/threonine kinase 10 4.8068
GATA2 GATA binding protein 2 4.64997
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.63825
ACLY ATP citrate lyase 2.79627
EBF2 early B-cell factor 2 2.67185
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.5855
MELK maternal embryonic leucine zipper kinase 2.5744
TAC1 tachykinin, precursor 1 2.46735
PDLIM1 PDZ and LIM domain 1 2.3557
CENPE centromere protein E, 312kDa 2.3224
KRTAP5-2 keratin associated protein 5-2 2.13515
PCNA proliferating cell nuclear antigen 2.0957
GSTM5 glutathione S-transferase mu 5 2.07345
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.01985
ABHD4 abhydrolase domain containing 4 2.0014
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.00035

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -4.8333
CTNND1 catenin (cadherin-associated protein), delta 1 -4.63073
DCK deoxycytidine kinase -3.73035
MTERF3 mitochondrial transcription termination factor 3 -3.16845
FAIM Fas apoptotic inhibitory molecule -2.3277
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.25995
CHMP7 charged multivesicular body protein 7 -2.12955
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.1022
MTFR1 mitochondrial fission regulator 1 -2.06078