CRCGN015_MCF10A.TP53.M_24H:G16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 10.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

337 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 7.03755
TXNRD1 thioredoxin reductase 1 6.85015
CNPY3 canopy FGF signaling regulator 3 6.24185
KLHL21 kelch-like family member 21 6.012
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 6.0075
SQSTM1 sequestosome 1 5.4112
FHL2 four and a half LIM domains 2 4.82655
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.81195
CTSL cathepsin L 4.73615
HMOX1 heme oxygenase 1 4.55065
RBKS ribokinase 4.44785
SCCPDH saccharopine dehydrogenase (putative) 4.31253
HMGA2 high mobility group AT-hook 2 4.0938
PRAF2 PRA1 domain family, member 2 4.06955
SQOR sulfide quinone oxidoreductase 4.0247
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.01085
IL1B interleukin 1, beta 3.79525
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.7442
LRP10 low density lipoprotein receptor-related protein 10 3.74315
CXCL2 chemokine (C-X-C motif) ligand 2 3.64545
IER3 immediate early response 3 3.52455
PYCR1 pyrroline-5-carboxylate reductase 1 3.5064
FOSL1 FOS-like antigen 1 3.47205
ZNF205 zinc finger protein 205 3.3927
GLRX glutaredoxin (thioltransferase) 3.30105
GOLGA3 golgin A3 3.25415
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.21923
CDCA4 cell division cycle associated 4 3.207
GCLM glutamate-cysteine ligase, modifier subunit 3.2064
GABARAP GABA(A) receptor-associated protein 3.1931
ELAVL3 ELAV like neuron-specific RNA binding protein 3 3.16585
LAGE3 L antigen family, member 3 3.1621
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 3.1155
ZNF358 zinc finger protein 358 3.10605
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 3.0674
TNIP1 TNFAIP3 interacting protein 1 3.0534
LIF leukemia inhibitory factor 3.03795
TPD52L2 tumor protein D52-like 2 3.02405
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.9631
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.9387
DUSP4 dual specificity phosphatase 4 2.85357
ATAD3A ATPase family, AAA domain containing 3A 2.82235
PTOV1 prostate tumor overexpressed 1 2.8199
DUSP6 dual specificity phosphatase 6 2.80992
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.79418
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.76415
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.71805
MNT MAX network transcriptional repressor 2.7145
TLCD3A TLC domain containing 3A 2.6945
F3 coagulation factor III (thromboplastin, tissue factor) 2.6779
STX1A syntaxin 1A (brain) 2.66365
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.6566
TRIM8 tripartite motif containing 8 2.6504
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.6489
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.6311
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.62755
EVA1B eva-1 homolog B (C. elegans) 2.62105
TMEM50A transmembrane protein 50A 2.59715
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.5894
EGR1 early growth response 1 2.58195
DVL1 dishevelled segment polarity protein 1 2.57965
P3H3 prolyl 3-hydroxylase 3 2.5746
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.57315
AGR2 anterior gradient 2 2.56945
CHMP4B charged multivesicular body protein 4B 2.52912
TSPAN4 tetraspanin 4 2.51947
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.5092
RALGDS ral guanine nucleotide dissociation stimulator 2.5082
KDSR 3-ketodihydrosphingosine reductase 2.5036
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.5034
SIRT1 sirtuin 1 2.4936
ANXA5 annexin A5 2.4927
SPX spexin hormone 2.46805
NRDC nardilysin convertase 2.4549
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.45377
P3H1 prolyl 3-hydroxylase 1 2.4512
CXCL3 chemokine (C-X-C motif) ligand 3 2.44575
MCUR1 mitochondrial calcium uniporter regulator 1 2.4322
COL7A1 collagen, type VII, alpha 1 2.42893
TERF2IP telomeric repeat binding factor 2, interacting protein 2.4222
GALE UDP-galactose-4-epimerase 2.4061
MORN1 MORN repeat containing 1 2.4002
TXLNA taxilin alpha 2.39325
NQO1 NAD(P)H dehydrogenase, quinone 1 2.37843
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.3765
SNX6 sorting nexin 6 2.3633
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.35945
SIL1 SIL1 nucleotide exchange factor 2.3576
COQ8A coenzyme Q8A 2.339
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.33645
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.32705
ITM2B integral membrane protein 2B 2.3239
BCAP31 B-cell receptor-associated protein 31 2.3125
GAA glucosidase, alpha; acid 2.28435
FUZ fuzzy planar cell polarity protein 2.28335
CBR1 carbonyl reductase 1 2.27075
ARID4A AT rich interactive domain 4A (RBP1-like) 2.2671
ITGB5 integrin, beta 5 2.2513
CHMP7 charged multivesicular body protein 7 2.24275
ADGRD2 adhesion G protein-coupled receptor D2 2.23435
BTBD3 BTB (POZ) domain containing 3 2.23165
WIF1 WNT inhibitory factor 1 2.2303
ERCC2 excision repair cross-complementation group 2 2.21815
IQCC IQ motif containing C 2.21445
MMP1 matrix metallopeptidase 1 2.2127
HSPA1A heat shock 70kDa protein 1A 2.2038
TMEM260 transmembrane protein 260 2.1917
ANO10 anoctamin 10 2.1755
KCTD17 potassium channel tetramerization domain containing 17 2.1712
GRN granulin 2.16813
MEA1 male-enhanced antigen 1 2.16205
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.15835
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.15655
FKBP10 FK506 binding protein 10, 65 kDa 2.14855
HSPA8 heat shock 70kDa protein 8 2.14385
CALU calumenin 2.13841
LAMC2 laminin, gamma 2 2.13808
DHPS deoxyhypusine synthase 2.1309
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.12785
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.12055
MAN2B1 mannosidase, alpha, class 2B, member 1 2.11343
TCF15 transcription factor 15 (basic helix-loop-helix) 2.10565
CUL7 cullin 7 2.10308
KIFBP kinesin family binding protein 2.10105
FURIN furin (paired basic amino acid cleaving enzyme) 2.09585
PCNA proliferating cell nuclear antigen 2.0957
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.0954
FOXO4 forkhead box O4 2.09185
UGDH UDP-glucose 6-dehydrogenase 2.0918
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 2.08905
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.08435
EGR3 early growth response 3 2.07505
ERP29 endoplasmic reticulum protein 29 2.07475
VTA1 vesicle (multivesicular body) trafficking 1 2.0658
RPN1 ribophorin I 2.06185
MOK MOK protein kinase 2.06145
HDLBP high density lipoprotein binding protein 2.03927
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.0359
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.02898
TPCN1 two pore segment channel 1 2.02645
NDE1 nudE neurodevelopment protein 1 2.0256
POMT2 protein-O-mannosyltransferase 2 2.0255
OSGIN1 oxidative stress induced growth inhibitor 1 2.0158
POMK protein-O-mannose kinase 2.01535
CCDC71 coiled-coil domain containing 71 2.00875
ZC2HC1A zinc finger, C2HC-type containing 1A 2.0047

decreased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 -7.65055
MSMO1 methylsterol monooxygenase 1 -5.9787
CAB39 calcium binding protein 39 -5.50925
HAT1 histone acetyltransferase 1 -5.4841
PRR15L proline rich 15-like -5.01935
HSPB1 heat shock 27kDa protein 1 -4.957
TSC22D3 TSC22 domain family, member 3 -4.9503
INSIG1 insulin induced gene 1 -4.88692
ALDOC aldolase C, fructose-bisphosphate -4.57465
DERA deoxyribose-phosphate aldolase (putative) -4.4001
HEATR1 HEAT repeat containing 1 -4.17583
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.1633
JMJD6 jumonji domain containing 6 -4.0091
TUBA4A tubulin, alpha 4a -3.8664
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.84095
ELAC2 elaC ribonuclease Z 2 -3.71995
PSRC1 proline/serine-rich coiled-coil 1 -3.66865
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.5405
INTS12 integrator complex subunit 12 -3.39065
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.3488
NLRP2B NLR family pyrin domain containing 2B -3.2959
MTERF3 mitochondrial transcription termination factor 3 -3.2841
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.25007
ZNF274 zinc finger protein 274 -3.2348
ACAA1 acetyl-CoA acyltransferase 1 -3.23415
RPA3 replication protein A3, 14kDa -3.21805
S100A4 S100 calcium binding protein A4 -3.20915
C1QBP complement component 1, q subcomponent binding protein -3.03373
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -3.02308
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -3.0081
RNF111 ring finger protein 111 -2.99905
CAPN1 calpain 1, (mu/I) large subunit -2.9969
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.9909
GTPBP8 GTP-binding protein 8 (putative) -2.97115
TIGAR TP53 induced glycolysis regulatory phosphatase -2.9579
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.9187
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.8913
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.8571
NOL11 nucleolar protein 11 -2.8091
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.8
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.79925
SMNDC1 survival motor neuron domain containing 1 -2.78785
LBR lamin B receptor -2.73375
GTF2A2 general transcription factor IIA, 2, 12kDa -2.72945
NDC1 NDC1 transmembrane nucleoporin -2.7167
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.68635
DBF4 DBF4 zinc finger -2.6523
TCF21 transcription factor 21 -2.6452
GRWD1 glutamate-rich WD repeat containing 1 -2.6446
KLK8 kallikrein-related peptidase 8 -2.63515
SRFBP1 serum response factor binding protein 1 -2.635
CCNB1 cyclin B1 -2.61045
DHCR7 7-dehydrocholesterol reductase -2.60632
NUP160 nucleoporin 160kDa -2.59823
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.59562
ZNF184 zinc finger protein 184 -2.5812
HBE1 hemoglobin, epsilon 1 -2.58085
PTGER4 prostaglandin E receptor 4 (subtype EP4) -2.55463
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.5475
MED21 mediator complex subunit 21 -2.52115
OIP5 Opa interacting protein 5 -2.5035
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.50255
RNF208 ring finger protein 208 -2.4884
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.4856
SC5D sterol-C5-desaturase -2.47887
FASTKD3 FAST kinase domains 3 -2.4608
FAM117A family with sequence similarity 117, member A -2.45385
PRR13 proline rich 13 -2.45135
PARPBP PARP1 binding protein -2.44875
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.44278
GDE1 glycerophosphodiester phosphodiesterase 1 -2.43725
HPGDS hematopoietic prostaglandin D synthase -2.43365
EHD4 EH-domain containing 4 -2.4179
ANAPC1 anaphase promoting complex subunit 1 -2.41565
NOP10 NOP10 ribonucleoprotein -2.41525
EFNA4 ephrin-A4 -2.4096
DCAF17 DDB1 and CUL4 associated factor 17 -2.40945
HOXA1 homeobox A1 -2.40535
RNF38 ring finger protein 38 -2.40015
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.3977
BFSP2 beaded filament structural protein 2, phakinin -2.3945
EPHA1 EPH receptor A1 -2.39275
SOAT2 sterol O-acyltransferase 2 -2.38402
HIP1 huntingtin interacting protein 1 -2.38065
MRPL44 mitochondrial ribosomal protein L44 -2.37785
MEIS2 Meis homeobox 2 -2.37475
MED28 mediator complex subunit 28 -2.3747
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.36865
MTO1 mitochondrial tRNA translation optimization 1 -2.36627
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.36118
RNF139 ring finger protein 139 -2.3587
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -2.35245
CASKIN2 CASK interacting protein 2 -2.3371
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.3325
ZDHHC13 zinc finger, DHHC-type containing 13 -2.31775
PEX13 peroxisomal biogenesis factor 13 -2.31155
ELOVL6 ELOVL fatty acid elongase 6 -2.30985
ZNF263 zinc finger protein 263 -2.3071
ACLY ATP citrate lyase -2.30392
NOP16 NOP16 nucleolar protein -2.30218
ARHGAP15 Rho GTPase activating protein 15 -2.29565
RGS2 regulator of G-protein signaling 2 -2.2886
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -2.2861
KRT24 keratin 24, type I -2.27035
OXSR1 oxidative stress responsive 1 -2.2565
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.25575
STK17B serine/threonine kinase 17b -2.2552
TK1 thymidine kinase 1, soluble -2.2414
ABT1 activator of basal transcription 1 -2.2396
STK38L serine/threonine kinase 38 like -2.23922
KLHL7 kelch-like family member 7 -2.23905
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.2362
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.2344
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.2281
PPID peptidylprolyl isomerase D -2.22747
INTS8 integrator complex subunit 8 -2.2259
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide -2.2233
NAT10 N-acetyltransferase 10 (GCN5-related) -2.21955
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.21785
RGS1 regulator of G-protein signaling 1 -2.21532
GPR87 G protein-coupled receptor 87 -2.21035
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide -2.20695
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.20475
MFAP1 microfibrillar-associated protein 1 -2.19315
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.18427
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.1832
FGF7 fibroblast growth factor 7 -2.18185
SLFN12 schlafen family member 12 -2.1799
PANX1 pannexin 1 -2.17775
FOXI1 forkhead box I1 -2.1728
CCNC cyclin C -2.1726
NXT1 nuclear transport factor 2-like export factor 1 -2.15715
SCGB1D1 secretoglobin, family 1D, member 1 -2.15035
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.1431
ERCC6L excision repair cross-complementation group 6-like -2.14235
TRIM52 tripartite motif containing 52 -2.1415
APOC3 apolipoprotein C-III -2.1415
CCDC88C coiled-coil domain containing 88C -2.13715
ZFP36L2 ZFP36 ring finger protein-like 2 -2.13685
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -2.13067
LCT lactase -2.1282
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 -2.1263
ZNF394 zinc finger protein 394 -2.12485
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.12075
ZNF35 zinc finger protein 35 -2.1206
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.1128
RMDN1 regulator of microtubule dynamics 1 -2.11165
INTS15 integrator complex subunit 15 -2.11098
E2F5 E2F transcription factor 5, p130-binding -2.11025
PER1 period circadian clock 1 -2.10835
SESN1 sestrin 1 -2.10835
USP39 ubiquitin specific peptidase 39 -2.1083
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -2.10655
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.1043
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.10177
TENT5C terminal nucleotidyltransferase 5C -2.09945
BNC2 basonuclin 2 -2.09925
PYDC1 PYD (pyrin domain) containing 1 -2.0973
WDCP WD repeat and coiled coil containing -2.0918
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.09095
APOH apolipoprotein H (beta-2-glycoprotein I) -2.08855
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.08535
PEX3 peroxisomal biogenesis factor 3 -2.0838
TMEM126B transmembrane protein 126B -2.0798
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -2.07482
FBXO41 F-box protein 41 -2.0745
STAP2 signal transducing adaptor family member 2 -2.071
MYH10 myosin, heavy chain 10, non-muscle -2.06865
MRPL49 mitochondrial ribosomal protein L49 -2.0677
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -2.06668
TXNL4B thioredoxin-like 4B -2.0656
ACACA acetyl-CoA carboxylase alpha -2.0596
CCNA2 cyclin A2 -2.0594
EIF1B eukaryotic translation initiation factor 1B -2.05675
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -2.0506
MTUS2 microtubule associated tumor suppressor candidate 2 -2.04735
ZNF557 zinc finger protein 557 -2.04455
PDZK1 PDZ domain containing 1 -2.04365
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0337
COPS7B COP9 signalosome subunit 7B -2.02655
COL10A1 collagen, type X, alpha 1 -2.02375
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.02272
TMEM255A transmembrane protein 255A -2.0205
POLR1F RNA polymerase I subunit F -2.01945
ARMC7 armadillo repeat containing 7 -2.0138
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.01215
AUNIP aurora kinase A and ninein interacting protein -2.01055
MAIP1 matrix AAA peptidase interacting protein 1 -2.0094
SLC30A10 solute carrier family 30, member 10 -2.0053
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.00405
MRPS7 mitochondrial ribosomal protein S7 -2.0027