CRCGN015_MCF10A.TP53.M_24H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 3.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

135 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 6.3485
MAMLD1 mastermind-like domain containing 1 6.17265
CARMIL1 capping protein regulator and myosin 1 linker 1 4.41165
DENND2D DENN/MADD domain containing 2D 4.36545
TOMM34 translocase of outer mitochondrial membrane 34 4.23565
TMEM50A transmembrane protein 50A 4.08955
STAP2 signal transducing adaptor family member 2 3.97125
LGMN legumain 3.51845
HMGA2 high mobility group AT-hook 2 3.4761
TIAM1 T-cell lymphoma invasion and metastasis 1 3.44205
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.39095
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.38285
SCCPDH saccharopine dehydrogenase (putative) 3.34525
FHL2 four and a half LIM domains 2 3.15925
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.96235
TSPAN4 tetraspanin 4 2.86893
CXCL2 chemokine (C-X-C motif) ligand 2 2.8561
CHMP4B charged multivesicular body protein 4B 2.62302
TIMP2 TIMP metallopeptidase inhibitor 2 2.54055
TROAP trophinin associated protein 2.52975
DUSP6 dual specificity phosphatase 6 2.52862
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.50935
IL1B interleukin 1, beta 2.5059
GSTZ1 glutathione S-transferase zeta 1 2.502
MOK MOK protein kinase 2.4959
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.4911
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.39935
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.37208
LSR lipolysis stimulated lipoprotein receptor 2.36175
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.3601
CAPN9 calpain 9 2.34078
MTA1 metastasis associated 1 2.31625
DUSP4 dual specificity phosphatase 4 2.2988
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta 2.2861
IER3 immediate early response 3 2.25525
ADAM28 ADAM metallopeptidase domain 28 2.25345
STX11 syntaxin 11 2.2471
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.2435
ITGA7 integrin, alpha 7 2.21745
EGR3 early growth response 3 2.2132
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.2067
TTC19 tetratricopeptide repeat domain 19 2.18575
EGR1 early growth response 1 2.17977
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.1559
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.15155
LALBA lactalbumin, alpha- 2.13595
CETN3 centrin, EF-hand protein, 3 2.10895
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.1001
SMAD3 SMAD family member 3 2.09455
ITGB5 integrin, beta 5 2.08798
MTM1 myotubularin 1 2.07977
FMNL3 formin-like 3 2.07845
CLDN16 claudin 16 2.0714
PLA1A phospholipase A1 member A 2.03875
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.038
CIRBP cold inducible RNA binding protein 2.03655
HOXD10 homeobox D10 2.0303
LCMT1 leucine carboxyl methyltransferase 1 2.0298
RAB21 RAB21, member RAS oncogene family 2.0257
TJP1 tight junction protein 1 2.01025
CCKAR cholecystokinin A receptor 2.00915
IFNB1 interferon, beta 1, fibroblast 2.0081

decreased expression

Symbol Name Standardized Value
STXBP2 syntaxin binding protein 2 -4.8078
CORO1A coronin, actin binding protein, 1A -4.7954
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.70967
DDIT4 DNA-damage-inducible transcript 4 -4.6037
HSPB1 heat shock 27kDa protein 1 -4.49865
ANKRD10 ankyrin repeat domain 10 -4.2792
ALDOC aldolase C, fructose-bisphosphate -3.8188
ISOC1 isochorismatase domain containing 1 -3.6438
S100A4 S100 calcium binding protein A4 -3.27045
ACAA1 acetyl-CoA acyltransferase 1 -3.26215
INSIG1 insulin induced gene 1 -3.19057
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -3.062
GRWD1 glutamate-rich WD repeat containing 1 -3.0564
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.9946
FKBP14 FK506 binding protein 14, 22 kDa -2.95175
PIH1D1 PIH1 domain containing 1 -2.93825
ZMYM2 zinc finger, MYM-type 2 -2.87527
MSMO1 methylsterol monooxygenase 1 -2.83285
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.83055
SLC25A46 solute carrier family 25, member 46 -2.8086
OXSR1 oxidative stress responsive 1 -2.796
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.75105
CLTC clathrin, heavy chain (Hc) -2.70005
HMOX1 heme oxygenase 1 -2.65235
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.64243
NGRN neugrin, neurite outgrowth associated -2.5239
PRR15L proline rich 15-like -2.494
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.45185
NLRP2B NLR family pyrin domain containing 2B -2.38565
MKRN2 makorin ring finger protein 2 -2.3834
DBF4 DBF4 zinc finger -2.37535
PGAM4 phosphoglycerate mutase family member 4 -2.35425
NDC1 NDC1 transmembrane nucleoporin -2.3494
ZNF574 zinc finger protein 574 -2.33935
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -2.3367
AARS1 alanyl-tRNA synthetase 1 -2.3229
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.31915
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.31865
CBR1 carbonyl reductase 1 -2.31175
SELENOT selenoprotein T -2.30725
H2BC12 H2B clustered histone 12 -2.30298
SESN1 sestrin 1 -2.2798
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.25847
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -2.2568
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.21935
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.19005
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.17648
AKTIP AKT interacting protein -2.1683
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.166
PGK1 phosphoglycerate kinase 1 -2.1652
FBRS fibrosin -2.13635
MAIP1 matrix AAA peptidase interacting protein 1 -2.12295
PSPC1 paraspeckle component 1 -2.09885
MPC2 mitochondrial pyruvate carrier 2 -2.0985
HOXA1 homeobox A1 -2.09545
RINT1 RAD50 interactor 1 -2.0912
CDC42 cell division cycle 42 -2.08493
VMP1 vacuole membrane protein 1 -2.0837
YME1L1 YME1-like 1 ATPase -2.08093
ZNF274 zinc finger protein 274 -2.07705
INPP1 inositol polyphosphate-1-phosphatase -2.0677
AEBP1 AE binding protein 1 -2.05475
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.05447
PSRC1 proline/serine-rich coiled-coil 1 -2.05445
PDCD10 programmed cell death 10 -2.044
ADGRE5 adhesion G protein-coupled receptor E5 -2.04345
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.0379
RGS2 regulator of G-protein signaling 2 -2.0357
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.03535
LOC128966597 MAL-like protein -2.02885
MYZAP myocardial zonula adherens protein -2.02375
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.0075
SEPHS2 selenophosphate synthetase 2 -2.0043