CRCGN015_MCF10A.TP53.M_24H:G18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 1.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

224 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.35635
GPER1 G protein-coupled estrogen receptor 1 5.23172
GRB10 growth factor receptor-bound protein 10 4.88913
PEX11A peroxisomal biogenesis factor 11 alpha 4.62673
CRELD2 cysteine-rich with EGF-like domains 2 4.22665
CHN1 chimerin 1 4.0625
LMF2 lipase maturation factor 2 3.7553
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.66625
COQ8A coenzyme Q8A 3.59645
HMGA2 high mobility group AT-hook 2 3.4536
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.4215
SCCPDH saccharopine dehydrogenase (putative) 3.3127
ACAA1 acetyl-CoA acyltransferase 1 3.1378
TMEM50A transmembrane protein 50A 3.131
CYB5R3 cytochrome b5 reductase 3 3.0098
EIF2D eukaryotic translation initiation factor 2D 3.00265
CXCL2 chemokine (C-X-C motif) ligand 2 2.96625
RBKS ribokinase 2.92438
IL1B interleukin 1, beta 2.89155
IRS1 insulin receptor substrate 1 2.8569
TNIP1 TNFAIP3 interacting protein 1 2.83125
LYRM4 LYR motif containing 4 2.80725
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 2.78935
THBS3 thrombospondin 3 2.7788
KIAA0930 KIAA0930 2.72975
ATXN10 ataxin 10 2.71403
SQOR sulfide quinone oxidoreductase 2.7119
DET1 de-etiolated homolog 1 (Arabidopsis) 2.6781
CCDC85B coiled-coil domain containing 85B 2.6746
F5 coagulation factor V (proaccelerin, labile factor) 2.66698
FAM3C family with sequence similarity 3, member C 2.58235
ERLIN2 ER lipid raft associated 2 2.57667
RALGDS ral guanine nucleotide dissociation stimulator 2.56383
HDAC4 histone deacetylase 4 2.53905
DAPL1 death associated protein-like 1 2.5051
PHB2 prohibitin 2 2.50435
CADM1 cell adhesion molecule 1 2.47865
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.47165
KLHDC2 kelch domain containing 2 2.44445
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.42595
AOX1 aldehyde oxidase 1 2.40688
PXDC1 PX domain containing 1 2.4029
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.4006
XKR8 XK, Kell blood group complex subunit-related family, member 8 2.3957
MTG1 mitochondrial ribosome-associated GTPase 1 2.39025
FRMD4A FERM domain containing 4A 2.38475
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.36345
STX7 syntaxin 7 2.3576
CHD1L chromodomain helicase DNA binding protein 1-like 2.35273
CUZD1 CUB and zona pellucida-like domains 1 2.34735
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2.34435
ITGB5 integrin, beta 5 2.32288
CIRBP cold inducible RNA binding protein 2.32282
COL17A1 collagen, type XVII, alpha 1 2.2989
CCN5 cellular communication network factor 5 2.29645
DUSP6 dual specificity phosphatase 6 2.29158
CDC45 cell division cycle 45 2.28145
ACKR3 atypical chemokine receptor 3 2.27885
BPHL biphenyl hydrolase-like (serine hydrolase) 2.2606
NBAS neuroblastoma amplified sequence 2.25895
CSPG4 chondroitin sulfate proteoglycan 4 2.24335
NINL ninein-like 2.2372
LRRC61 leucine rich repeat containing 61 2.2146
PDIA2 protein disulfide isomerase family A, member 2 2.2094
ADGRG6 adhesion G protein-coupled receptor G6 2.20225
HDLBP high density lipoprotein binding protein 2.18245
SETD6 SET domain containing 6 2.18075
DRC3 dynein regulatory complex subunit 3 2.17595
TMEM222 transmembrane protein 222 2.16885
QARS1 glutaminyl-tRNA synthetase 1 2.15745
WDR19 WD repeat domain 19 2.1531
ARSA arylsulfatase A 2.15305
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.14305
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.13375
RNF123 ring finger protein 123 2.13285
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.13015
UCKL1 uridine-cytidine kinase 1-like 1 2.1282
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 2.12563
ADRB2 adrenoceptor beta 2, surface 2.11375
COL9A1 collagen, type IX, alpha 1 2.11215
FHL2 four and a half LIM domains 2 2.1084
CLCA2 chloride channel accessory 2 2.09912
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.09678
DCTN1 dynactin 1 2.0888
FAAP100 FA core complex associated protein 100 2.0842
MATN1 matrilin 1, cartilage matrix protein 2.08075
CHKB choline kinase beta 2.07625
ANXA10 annexin A10 2.05295
AGBL5 ATP/GTP binding protein-like 5 2.05195
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.03665
ADSL adenylosuccinate lyase 2.0322
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.0233
PWP1 PWP1 homolog (S. cerevisiae) 2.01852
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.0161
SOD3 superoxide dismutase 3, extracellular 2.0157
ADH6 alcohol dehydrogenase 6 (class V) 2.00763
WIF1 WNT inhibitory factor 1 2.0053
CPQ carboxypeptidase Q 2.00268

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -7.24555
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -5.76905
NSDHL NAD(P) dependent steroid dehydrogenase-like -5.06005
HMG20B high mobility group 20B -4.82468
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.51415
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.49992
PUF60 poly-U binding splicing factor 60KDa -4.41055
NPDC1 neural proliferation, differentiation and control, 1 -4.3827
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.2621
HSPB1 heat shock 27kDa protein 1 -4.10915
CD81 CD81 molecule -3.89335
KRT14 keratin 14, type I -3.8655
CHMP4B charged multivesicular body protein 4B -3.66937
VBP1 von Hippel-Lindau binding protein 1 -3.59735
S100A4 S100 calcium binding protein A4 -3.5596
INSIG1 insulin induced gene 1 -3.54435
EIF5 eukaryotic translation initiation factor 5 -3.39251
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.30405
DDIT4 DNA-damage-inducible transcript 4 -3.26015
ANXA2 annexin A2 -3.18738
MTERF3 mitochondrial transcription termination factor 3 -3.0584
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.03405
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -3.01745
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.9775
OXSR1 oxidative stress responsive 1 -2.96795
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.94685
ALDOC aldolase C, fructose-bisphosphate -2.92105
PRR15L proline rich 15-like -2.8585
RBM34 RNA binding motif protein 34 -2.7536
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.74065
TGDS TDP-glucose 4,6-dehydratase -2.72745
GSDMD gasdermin D -2.71615
TPM4 tropomyosin 4 -2.71532
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.7039
TRIM38 tripartite motif containing 38 -2.699
ZNF430 zinc finger protein 430 -2.67405
MTMR6 myotubularin related protein 6 -2.63
VAMP7 vesicle-associated membrane protein 7 -2.61945
ZNF274 zinc finger protein 274 -2.60935
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.59815
TMEM126B transmembrane protein 126B -2.58355
LDHD lactate dehydrogenase D -2.5832
SSR4 signal sequence receptor, delta -2.54275
EMD emerin -2.5424
NELL1 NEL-like 1 (chicken) -2.52845
INPP1 inositol polyphosphate-1-phosphatase -2.5053
TUBA4A tubulin, alpha 4a -2.50295
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -2.50125
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -2.47563
CGRRF1 cell growth regulator with ring finger domain 1 -2.46155
YY1AP1 YY1 associated protein 1 -2.45025
TRIB3 tribbles pseudokinase 3 -2.44115
FKBP14 FK506 binding protein 14, 22 kDa -2.4308
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.43025
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.42365
PPID peptidylprolyl isomerase D -2.42158
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.4066
NLRP2B NLR family pyrin domain containing 2B -2.39385
TARS1 threonyl-tRNA synthetase 1 -2.38835
BCAP31 B-cell receptor-associated protein 31 -2.383
AARS1 alanyl-tRNA synthetase 1 -2.3794
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.36865
KRT18 keratin 18, type I -2.3592
INTS8 integrator complex subunit 8 -2.3451
TRAK2 trafficking protein, kinesin binding 2 -2.33225
EXOSC8 exosome component 8 -2.32565
STAP2 signal transducing adaptor family member 2 -2.32535
ITCH itchy E3 ubiquitin protein ligase -2.31498
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.30925
IRAK1 interleukin-1 receptor-associated kinase 1 -2.2973
GTPBP8 GTP-binding protein 8 (putative) -2.2955
MSMO1 methylsterol monooxygenase 1 -2.29295
RNASE7 ribonuclease, RNase A family, 7 -2.29055
DHCR7 7-dehydrocholesterol reductase -2.28238
CDC42SE1 CDC42 small effector 1 -2.2805
RCOR3 REST corepressor 3 -2.2688
SELENOT selenoprotein T -2.26545
DENND4C DENN/MADD domain containing 4C -2.25665
TYW2 tRNA wybutosine-synthesizing protein 2 -2.25085
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.2373
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.2321
LBR lamin B receptor -2.2275
CBR3 carbonyl reductase 3 -2.2213
YAF2 YY1 associated factor 2 -2.21205
INPPL1 inositol polyphosphate phosphatase-like 1 -2.2087
CISD1 CDGSH iron sulfur domain 1 -2.2071
ARMCX5 armadillo repeat containing, X-linked 5 -2.2003
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -2.19935
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.1941
NUP58 nucleoporin 58 -2.1909
KYAT3 kynurenine aminotransferase 3 -2.1904
PLS1 plastin 1 -2.19
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.1862
COPS5 COP9 signalosome subunit 5 -2.1819
PFN1 profilin 1 -2.17725
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.1725
SESN1 sestrin 1 -2.17235
GRAMD1B GRAM domain containing 1B -2.1617
BTN2A1 butyrophilin, subfamily 2, member A1 -2.16017
SH3D19 SH3 domain containing 19 -2.15895
SLC25A46 solute carrier family 25, member 46 -2.1418
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.13845
AGPS alkylglycerone phosphate synthase -2.13235
ING1 inhibitor of growth family, member 1 -2.12723
PITPNA phosphatidylinositol transfer protein, alpha -2.12225
ZMPSTE24 zinc metallopeptidase STE24 -2.12025
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.108
OSMR oncostatin M receptor -2.1075
CLTC clathrin, heavy chain (Hc) -2.0955
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.09282
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.08345
GTF2A2 general transcription factor IIA, 2, 12kDa -2.0807
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.06853
TMEM87A transmembrane protein 87A -2.0523
TICAM1 toll-like receptor adaptor molecule 1 -2.05
NSUN3 NOP2/Sun domain family, member 3 -2.0459
PRKCB protein kinase C, beta -2.03335
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.0333
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.0306
PTS 6-pyruvoyltetrahydropterin synthase -2.0281
NEFH neurofilament, heavy polypeptide -2.0276
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.01135
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.00655
SAP30BP SAP30 binding protein -2.00615
ANAPC10 anaphase promoting complex subunit 10 -2.00525
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.0031