CRCGN015_MCF10A.TP53.M_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 99.01 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KDM5D lysine (K)-specific demethylase 5D 7.78215
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 7.1859
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 6.32257
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.99095
USP9Y ubiquitin specific peptidase 9, Y-linked 5.68435
HBA1 hemoglobin, alpha 1 5.48403
ADAM10 ADAM metallopeptidase domain 10 4.76487
ZFY zinc finger protein, Y-linked 4.67785
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 4.37495
HBB hemoglobin, beta 4.19275
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3.91705
FGFR4 fibroblast growth factor receptor 4 3.80008
DENND2D DENN/MADD domain containing 2D 3.1991
NOSIP nitric oxide synthase interacting protein 3.1496
NLGN4Y neuroligin 4, Y-linked 2.60955
RPS4Y1 ribosomal protein S4, Y-linked 1 2.57475
SLC75A1 solute carrier family 75 member 1 2.19475
CCNF cyclin F 2.14655
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.13982
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.11785

decreased expression

Symbol Name Standardized Value
KDM5C lysine (K)-specific demethylase 5C -6.1951
SMC1A structural maintenance of chromosomes 1A -5.79838
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -5.78986
PUDP pseudouridine 5'-phosphatase -5.6769
NPDC1 neural proliferation, differentiation and control, 1 -5.53035
UBA1 ubiquitin-like modifier activating enzyme 1 -5.36405
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -4.73465
KDM6A lysine (K)-specific demethylase 6A -4.06518
PNPLA4 patatin-like phospholipase domain containing 4 -3.7865
USP9X ubiquitin specific peptidase 9, X-linked -3.7538
OFD1 oral-facial-digital syndrome 1 -3.07875
COTL1 coactosin-like F-actin binding protein 1 -2.84685
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.68572
RAB9A RAB9A, member RAS oncogene family -2.611
THAP11 THAP domain containing 11 -2.5783
GPR20 G protein-coupled receptor 20 -2.26035
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.2089
CDK16 cyclin-dependent kinase 16 -2.14132
GTPBP6 GTP binding protein 6 (putative) -2.11945
DDAH1 dimethylarginine dimethylaminohydrolase 1 -2.0393