CRCGN015_MCF10A.TP53.M_24H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 33.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 5.53497
CCP110 centriolar coiled coil protein 110kDa 5.1547
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.07728
KDM5A lysine (K)-specific demethylase 5A 4.65518
HMOX1 heme oxygenase 1 3.6359
ACAA1 acetyl-CoA acyltransferase 1 3.50838
NOTCH1 notch 1 3.12545
BTK Bruton agammaglobulinemia tyrosine kinase 2.73365
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.7335
MYL11 myosin light chain 11 2.5746
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.4105
TNNI1 troponin I type 1 (skeletal, slow) 2.3506
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.34142
GARRE1 granule associated Rac and RHOG effector 1 2.3405
CADPS2 Ca++-dependent secretion activator 2 2.3324
FOXM1 forkhead box M1 2.31355
CKM creatine kinase, muscle 2.21595
FBXL12 F-box and leucine-rich repeat protein 12 2.17985
AGR2 anterior gradient 2 2.13915
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.1365
GOLGA8F golgin A8 family, member F 2.1261
TNNC2 troponin C type 2 (fast) 2.11705
ZEB2 zinc finger E-box binding homeobox 2 2.10625
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.08205
NRBF2 nuclear receptor binding factor 2 2.04915
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.01365
MYBPH myosin binding protein H 2.00125

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -4.89213
HSPA1A heat shock 70kDa protein 1A -3.12625
THAP11 THAP domain containing 11 -2.3746
PRRX2 paired related homeobox 2 -2.1772
RBM7 RNA binding motif protein 7 -2.0763
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.06005