CRCGN015_MCF10A.TP53.M_24H:G21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 11.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

115 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 10.0
ANO10 anoctamin 10 5.6452
AMDHD2 amidohydrolase domain containing 2 4.92195
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.62569
EPHB2 EPH receptor B2 3.97127
COMP cartilage oligomeric matrix protein 3.1273
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.9037
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.7533
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.73853
MISP mitotic spindle positioning 2.7331
RBBP5 retinoblastoma binding protein 5 2.6872
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.67445
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 2.59242
NUTF2 nuclear transport factor 2 2.5914
ANAPC15 anaphase promoting complex subunit 15 2.48545
CENPE centromere protein E, 312kDa 2.48005
USP6 ubiquitin specific peptidase 6 2.4758
BAMBI BMP and activin membrane-bound inhibitor 2.428
LIPT1 lipoyltransferase 1 2.40435
FOXD1 forkhead box D1 2.38625
DOK5 docking protein 5 2.38485
CEPT1 choline/ethanolamine phosphotransferase 1 2.3462
DRAM1 DNA-damage regulated autophagy modulator 1 2.32185
GSTK1 glutathione S-transferase kappa 1 2.31265
NFU1 NFU1 iron-sulfur cluster scaffold 2.29105
TRIM24 tripartite motif containing 24 2.27065
DPY19L1 dpy-19-like 1 (C. elegans) 2.26685
NXT2 nuclear transport factor 2-like export factor 2 2.24003
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.22715
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.22165
MTA2 metastasis associated 1 family, member 2 2.1689
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.1621
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.15973
SNX3 sorting nexin 3 2.15147
ODF2 outer dense fiber of sperm tails 2 2.15055
NOSIP nitric oxide synthase interacting protein 2.10795
MRPL18 mitochondrial ribosomal protein L18 2.10255
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.0941
TLK1 tousled-like kinase 1 2.09072
SHCBP1 SHC SH2-domain binding protein 1 2.0869
BMP6 bone morphogenetic protein 6 2.0649
PES1 pescadillo ribosomal biogenesis factor 1 2.0514
ODAM odontogenic, ameloblast asssociated 2.0356
CLOCK clock circadian regulator 2.02965
COL2A1 collagen, type II, alpha 1 2.02063
THRAP3 thyroid hormone receptor associated protein 3 2.0206
HMGN3 high mobility group nucleosomal binding domain 3 2.01065
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.00618
BRMS1L breast cancer metastasis-suppressor 1-like 2.0056
YIPF5 Yip1 domain family, member 5 2.00165

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.553
YME1L1 YME1-like 1 ATPase -4.119
KRT14 keratin 14, type I -4.109
NT5DC2 5'-nucleotidase domain containing 2 -3.8991
NVL nuclear VCP-like -3.65665
BASP1 brain abundant, membrane attached signal protein 1 -3.39765
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.16122
COG5 component of oligomeric golgi complex 5 -2.91278
LAMB1 laminin, beta 1 -2.9002
NELL2 NEL-like 2 (chicken) -2.78995
ATP11B ATPase, class VI, type 11B -2.72
RNF144A ring finger protein 144A -2.66235
IL2RA interleukin 2 receptor, alpha -2.6113
MMP11 matrix metallopeptidase 11 -2.54958
EXT1 exostosin glycosyltransferase 1 -2.53708
CPB1 carboxypeptidase B1 (tissue) -2.52825
CMTR1 cap methyltransferase 1 -2.52785
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.41412
ZNF76 zinc finger protein 76 -2.40785
POMZP3 POM121 and ZP3 fusion -2.38928
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.35923
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -2.35687
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.2983
SREBF1 sterol regulatory element binding transcription factor 1 -2.28325
ILF2 interleukin enhancer binding factor 2 -2.2633
FCMR Fc fragment of IgM receptor -2.26223
MAP3K11 mitogen-activated protein kinase kinase kinase 11 -2.25465
GPR22 G protein-coupled receptor 22 -2.2331
ANKRD26 ankyrin repeat domain 26 -2.22808
RNF38 ring finger protein 38 -2.21205
GREB1L growth regulation by estrogen in breast cancer-like -2.2039
FADS2 fatty acid desaturase 2 -2.2033
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -2.18935
TRIM31 tripartite motif containing 31 -2.18022
OXR1 oxidation resistance 1 -2.17965
CARTPT CART prepropeptide -2.17535
KIF13B kinesin family member 13B -2.1748
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.1713
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.1707
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.15435
BCAP29 B-cell receptor-associated protein 29 -2.1436
BTNL8 butyrophilin-like 8 -2.13755
CAVIN1 caveolae associated protein 1 -2.1286
TMEM39B transmembrane protein 39B -2.10725
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.10265
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -2.0946
IVNS1ABP influenza virus NS1A binding protein -2.08955
NID1 nidogen 1 -2.08812
ADAM7 ADAM metallopeptidase domain 7 -2.08523
R3HDM2 R3H domain containing 2 -2.08285
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.07585
PLPP1 phospholipid phosphatase 1 -2.0698
UNC13A unc-13 homolog A (C. elegans) -2.06845
CD83 CD83 molecule -2.04765
VCPKMT valosin containing protein lysine (K) methyltransferase -2.0437
ZFAND1 zinc finger, AN1-type domain 1 -2.04205
RPAP2 RNA polymerase II associated protein 2 -2.0409
ATRNL1 attractin-like 1 -2.027
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.02255
C1QBP complement component 1, q subcomponent binding protein -2.01977
FBXL7 F-box and leucine-rich repeat protein 7 -2.01955
SLC49A3 solute carrier family 49 member 3 -2.01585
FBXO28 F-box protein 28 -2.01533
SSH1 slingshot protein phosphatase 1 -2.0036
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 -2.0013