| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4,8-dihydroxy-2-quinolinecarboxylic acid 99.88 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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279 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LAGE3 | L antigen family, member 3 | 10.0 |
| KDM5D | lysine (K)-specific demethylase 5D | 8.5348 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 7.43805 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 7.1024 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 6.52785 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 6.0452 |
| ZFY | zinc finger protein, Y-linked | 5.8962 |
| WIF1 | WNT inhibitory factor 1 | 5.5248 |
| APTX | aprataxin | 5.1636 |
| DENND2D | DENN/MADD domain containing 2D | 4.6111 |
| MRM3 | mitochondrial rRNA methyltransferase 3 | 4.499 |
| SLC10A3 | solute carrier family 10, member 3 | 4.2103 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 4.1037 |
| F8A2 | coagulation factor VIII-associated 2 | 4.0864 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 4.0258 |
| VAMP7 | vesicle-associated membrane protein 7 | 3.9132 |
| NLGN4Y | neuroligin 4, Y-linked | 3.8816 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 3.80183 |
| SSR4 | signal sequence receptor, delta | 3.6983 |
| FAM3A | family with sequence similarity 3, member A | 3.5586 |
| TRAPPC6A | trafficking protein particle complex 6A | 3.2753 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 3.2517 |
| CMC4 | C-x(9)-C motif containing 4 | 3.2482 |
| VBP1 | von Hippel-Lindau binding protein 1 | 3.198 |
| HBE1 | hemoglobin, epsilon 1 | 3.1767 |
| NANS | N-acetylneuraminic acid synthase | 3.1551 |
| BAMBI | BMP and activin membrane-bound inhibitor | 3.0962 |
| BBLN | bublin coiled coil protein | 3.0524 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 3.0147 |
| ACBD3 | acyl-CoA binding domain containing 3 | 2.99975 |
| UBL4A | ubiquitin-like 4A | 2.9709 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 2.968 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.9316 |
| TFB2M | transcription factor B2, mitochondrial | 2.9284 |
| DNASE1L1 | deoxyribonuclease I-like 1 | 2.9122 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | 2.9108 |
| FAM50A | family with sequence similarity 50, member A | 2.9006 |
| MLST8 | MTOR associated protein, LST8 homolog (S. cerevisiae) | 2.8619 |
| TOPORS | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase | 2.8295 |
| LYRM1 | LYR motif containing 1 | 2.8228 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | 2.8101 |
| TAFAZZIN | tafazzin, phospholipid-lysophospholipid transacylase | 2.78955 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.7741 |
| IDH3G | isocitrate dehydrogenase 3 (NAD+) gamma | 2.7692 |
| HOXB13 | homeobox B13 | 2.7505 |
| TBPL1 | TBP-like 1 | 2.636 |
| CDC37L1 | cell division cycle 37-like 1 | 2.6208 |
| CETN2 | centrin, EF-hand protein, 2 | 2.59 |
| MACROD1 | MACRO domain containing 1 | 2.5654 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 2.5568 |
| FMR1 | fragile X mental retardation 1 | 2.5363 |
| SCAND1 | SCAN domain containing 1 | 2.5229 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 2.5159 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 2.5139 |
| EOLA1 | endothelium and lymphocyte associated ASCH domain 1 | 2.4458 |
| GFRA1 | GDNF family receptor alpha 1 | 2.4398 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 2.436 |
| GABRB1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | 2.4233 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 2.42275 |
| UROS | uroporphyrinogen III synthase | 2.4201 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 2.42005 |
| MPC1 | mitochondrial pyruvate carrier 1 | 2.4167 |
| ERBIN | erbb2 interacting protein | 2.3961 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 2.3863 |
| TMSB4Y | thymosin beta 4, Y-linked | 2.3664 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 2.3533 |
| PEX11B | peroxisomal biogenesis factor 11 beta | 2.3379 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | 2.3356 |
| RWDD2B | RWD domain containing 2B | 2.3354 |
| ANKRD28 | ankyrin repeat domain 28 | 2.3235 |
| SESN1 | sestrin 1 | 2.3214 |
| BCAS2 | breast carcinoma amplified sequence 2 | 2.3174 |
| ARL2 | ADP-ribosylation factor-like 2 | 2.3084 |
| CASP8AP2 | caspase 8 associated protein 2 | 2.2987 |
| COX6A1 | cytochrome c oxidase subunit VIa polypeptide 1 | 2.2897 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.2897 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 2.286 |
| F8 | coagulation factor VIII, procoagulant component | 2.2857 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | 2.2722 |
| DGCR6L | DiGeorge syndrome critical region gene 6-like | 2.2599 |
| VPS45 | vacuolar protein sorting 45 homolog (S. cerevisiae) | 2.2519 |
| GTF2E1 | general transcription factor IIE, polypeptide 1, alpha 56kDa | 2.2515 |
| FLNA | filamin A, alpha | 2.24937 |
| TSEN34 | TSEN34 tRNA splicing endonuclease subunit | 2.2446 |
| GOLPH3L | golgi phosphoprotein 3-like | 2.228 |
| PDLIM1 | PDZ and LIM domain 1 | 2.2262 |
| GCC1 | GRIP and coiled-coil domain containing 1 | 2.2204 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 2.2152 |
| FBXO5 | F-box protein 5 | 2.2139 |
| MRPL30 | mitochondrial ribosomal protein L30 | 2.2096 |
| RBMY1J | RNA binding motif protein, Y-linked, family 1, member J | 2.2062 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 2.2051 |
| GDI1 | GDP dissociation inhibitor 1 | 2.2007 |
| MYL6B | myosin, light chain 6B, alkali, smooth muscle and non-muscle | 2.2006 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 2.1988 |
| CCDC59 | coiled-coil domain containing 59 | 2.1982 |
| BET1 | Bet1 golgi vesicular membrane trafficking protein | 2.1858 |
| MECP2 | methyl CpG binding protein 2 | 2.17283 |
| PEX10 | peroxisomal biogenesis factor 10 | 2.1637 |
| NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | 2.1636 |
| DAZAP2 | DAZ associated protein 2 | 2.1632 |
| GTF2H5 | general transcription factor IIH, polypeptide 5 | 2.1491 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 2.1474 |
| DAZ2 | deleted in azoospermia 2 | 2.14408 |
| RABL3 | RAB, member of RAS oncogene family-like 3 | 2.138 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 2.1299 |
| COPS7A | COP9 signalosome subunit 7A | 2.1119 |
| NISCH | nischarin | 2.1119 |
| BGLAP | bone gamma-carboxyglutamate (gla) protein | 2.1092 |
| KRCC1 | lysine-rich coiled-coil 1 | 2.1078 |
| GAMT | guanidinoacetate N-methyltransferase | 2.1049 |
| ERI3 | ERI1 exoribonuclease family member 3 | 2.0956 |
| NDUFA8 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa | 2.0844 |
| PPP6C | protein phosphatase 6, catalytic subunit | 2.08335 |
| BCAP31 | B-cell receptor-associated protein 31 | 2.0833 |
| YTHDC1 | YTH domain containing 1 | 2.0803 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 2.0796 |
| HEMK2 | HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine | 2.0748 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 2.071 |
| RWDD1 | RWD domain containing 1 | 2.0707 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 2.0643 |
| ICOS | inducible T-cell co-stimulator | 2.0626 |
| SCAI | suppressor of cancer cell invasion | 2.056 |
| ZC3H4 | zinc finger CCCH-type containing 4 | 2.0548 |
| DAD1 | defender against cell death 1 | 2.0527 |
| SERF2 | small EDRK-rich factor 2 | 2.04433 |
| THTPA | thiamine triphosphatase | 2.0424 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 2.0345 |
| WTAP | Wilms tumor 1 associated protein | 2.03285 |
| TENT2 | terminal nucleotidyltransferase 2 | 2.0325 |
| ZNF668 | zinc finger protein 668 | 2.028 |
| CSF3R | colony stimulating factor 3 receptor (granulocyte) | 2.0241 |
| LUM | lumican | 2.0228 |
| CRYZ | crystallin, zeta (quinone reductase) | 2.0188 |
| MVP | major vault protein | 2.0134 |
| KCMF1 | potassium channel modulatory factor 1 | 2.0128 |
| MAIP1 | matrix AAA peptidase interacting protein 1 | 2.0042 |
| TMEM187 | transmembrane protein 187 | 2.0028 |
| SIX1 | SIX homeobox 1 | 2.0021 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NUP85 | nucleoporin 85kDa | -10.0 |
| SMC1A | structural maintenance of chromosomes 1A | -6.6136 |
| MRPS7 | mitochondrial ribosomal protein S7 | -6.2535 |
| KDM5C | lysine (K)-specific demethylase 5C | -5.9509 |
| PUDP | pseudouridine 5'-phosphatase | -5.7204 |
| TMEM94 | transmembrane protein 94 | -5.3483 |
| LOC124905557 | eukaryotic translation initiation factor 1A, X-chromosomal | -4.99883 |
| PRPSAP1 | phosphoribosyl pyrophosphate synthetase-associated protein 1 | -4.9882 |
| SAP30BP | SAP30 binding protein | -4.7101 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.6445 |
| MRPL58 | mitochondrial ribosomal protein L58 | -4.6262 |
| KDM6A | lysine (K)-specific demethylase 6A | -4.56747 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -4.4715 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -4.3802 |
| GGA3 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3 | -4.37485 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -4.1304 |
| ACOX1 | acyl-CoA oxidase 1, palmitoyl | -3.92525 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -3.858 |
| SUMO4 | small ubiquitin-like modifier 4 | -3.8472 |
| JPT1 | Jupiter microtubule associated homolog 1 | -3.7908 |
| NT5C | 5', 3'-nucleotidase, cytosolic | -3.6533 |
| CASKIN2 | CASK interacting protein 2 | -3.54525 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -3.4374 |
| UCKL1 | uridine-cytidine kinase 1-like 1 | -3.4351 |
| CDR2L | cerebellar degeneration-related protein 2-like | -3.2746 |
| WBP2 | WW domain binding protein 2 | -3.2524 |
| MAP3K6 | mitogen-activated protein kinase kinase kinase 6 | -3.1442 |
| CBR3 | carbonyl reductase 3 | -3.0844 |
| LIPG | lipase, endothelial | -3.0833 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -3.05464 |
| DELE1 | DAP3 binding cell death enhancer 1 | -3.03165 |
| PRKAB2 | protein kinase, AMP-activated, beta 2 non-catalytic subunit | -2.9276 |
| PNPLA4 | patatin-like phospholipase domain containing 4 | -2.8667 |
| BRD9 | bromodomain containing 9 | -2.8603 |
| SNX7 | sorting nexin 7 | -2.8554 |
| WDR11 | WD repeat domain 11 | -2.838 |
| TRAPPC2 | trafficking protein particle complex 2 | -2.83285 |
| NSMCE4A | non-SMC element 4 homolog A (S. cerevisiae) | -2.82505 |
| CENPT | centromere protein T | -2.8201 |
| NIT1 | nitrilase 1 | -2.75 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | -2.7307 |
| H3-3B | H3.3 histone B | -2.70722 |
| CCNL2 | cyclin L2 | -2.7033 |
| CLASRP | CLK4-associating serine/arginine rich protein | -2.6981 |
| SDK2 | sidekick cell adhesion molecule 2 | -2.6882 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -2.6832 |
| CAVIN3 | caveolae associated protein 3 | -2.6701 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.6561 |
| GRB2 | growth factor receptor-bound protein 2 | -2.6448 |
| SEPTIN6 | septin 6 | -2.61734 |
| GPS1 | G protein pathway suppressor 1 | -2.6071 |
| ZNF266 | zinc finger protein 266 | -2.6052 |
| TPPP | tubulin polymerization promoting protein | -2.6025 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -2.5916 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | -2.5709 |
| NSUN3 | NOP2/Sun domain family, member 3 | -2.5449 |
| SLC16A2 | solute carrier family 16, member 2 (thyroid hormone transporter) | -2.5325 |
| BCL6 | B-cell CLL/lymphoma 6 | -2.53095 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -2.53035 |
| TTC12 | tetratricopeptide repeat domain 12 | -2.5288 |
| SLC38A12 | solute carrier family 38 member 12 | -2.5006 |
| LARP7 | La ribonucleoprotein domain family, member 7 | -2.4986 |
| ENGASE | endo-beta-N-acetylglucosaminidase | -2.47945 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -2.4756 |
| ECHDC2 | enoyl CoA hydratase domain containing 2 | -2.4703 |
| RGS2 | regulator of G-protein signaling 2 | -2.4657 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | -2.4652 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -2.4601 |
| LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae) | -2.4378 |
| PALLD | palladin, cytoskeletal associated protein | -2.40993 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -2.4 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | -2.3894 |
| OFD1 | oral-facial-digital syndrome 1 | -2.3721 |
| SCARA3 | scavenger receptor class A, member 3 | -2.3704 |
| MEFV | Mediterranean fever | -2.3664 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -2.362 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -2.34877 |
| DIO3 | deiodinase, iodothyronine, type III | -2.3426 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -2.3253 |
| NOD1 | nucleotide-binding oligomerization domain containing 1 | -2.3109 |
| PRSS22 | protease, serine, 22 | -2.3031 |
| STS | steroid sulfatase (microsomal), isozyme S | -2.28615 |
| RASL12 | RAS-like, family 12 | -2.2648 |
| LMTK1 | lemur tail kinase 1 | -2.2644 |
| RRM1 | ribonucleotide reductase M1 | -2.26135 |
| DHX38 | DEAH (Asp-Glu-Ala-His) box polypeptide 38 | -2.2379 |
| MRNIP | MRN complex interacting protein | -2.2316 |
| TUBA4A | tubulin, alpha 4a | -2.2245 |
| LONP1 | lon peptidase 1, mitochondrial | -2.224 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | -2.2157 |
| INTS11 | integrator complex subunit 11 | -2.2101 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -2.2075 |
| TNNC2 | troponin C type 2 (fast) | -2.2071 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -2.2055 |
| ZNF516 | zinc finger protein 516 | -2.2032 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -2.1906 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | -2.1882 |
| IMMT | inner membrane protein, mitochondrial | -2.178 |
| POMT2 | protein-O-mannosyltransferase 2 | -2.1762 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | -2.16715 |
| ACE2 | angiotensin I converting enzyme 2 | -2.16085 |
| GSTM5 | glutathione S-transferase mu 5 | -2.1601 |
| THG1L | tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) | -2.1589 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -2.1555 |
| TUBA3C | tubulin, alpha 3c | -2.147 |
| ADRM1 | adhesion regulating molecule 1 | -2.1459 |
| SCHIP1 | schwannomin interacting protein 1 | -2.1454 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -2.14187 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -2.1395 |
| SPAG1 | sperm associated antigen 1 | -2.1373 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | -2.13435 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -2.1311 |
| SDC2 | syndecan 2 | -2.12443 |
| ARAP1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | -2.12435 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 | -2.11925 |
| CCDC47 | coiled-coil domain containing 47 | -2.1173 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -2.1107 |
| ZC4H2 | zinc finger, C4H2 domain containing | -2.1097 |
| DAND5 | DAN domain family member 5, BMP antagonist | -2.107 |
| CES1 | carboxylesterase 1 | -2.1041 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -2.0866 |
| ZNF816 | zinc finger protein 816 | -2.0766 |
| HOXC4 | homeobox C4 | -2.0754 |
| DGKD | diacylglycerol kinase, delta 130kDa | -2.0722 |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit | -2.07095 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -2.0656 |
| BLVRA | biliverdin reductase A | -2.05787 |
| TTR | transthyretin | -2.04845 |
| TTC31 | tetratricopeptide repeat domain 31 | -2.0448 |
| NOTCH4 | notch 4 | -2.0381 |
| BRD7 | bromodomain containing 7 | -2.0336 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -2.032 |
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 | -2.028 |
| FHIP2B | FHF complex subunit HOOK interacting protein 2B | -2.0277 |
| MED24 | mediator complex subunit 24 | -2.0243 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | -2.0187 |
| FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | -2.0176 |
| INPPL1 | inositol polyphosphate phosphatase-like 1 | -2.0163 |
| MSL1 | male-specific lethal 1 homolog (Drosophila) | -2.0074 |
| ZFP36 | ZFP36 ring finger protein | -2.0041 |
