CRCGN015_MCF10A.TP53.M_24H:G23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 33.29 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:G23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.1845
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.37795
RNF167 ring finger protein 167 3.1837
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.55645
PDLIM1 PDZ and LIM domain 1 2.55
BPHL biphenyl hydrolase-like (serine hydrolase) 2.39695
NVL nuclear VCP-like 2.2907
GARRE1 granule associated Rac and RHOG effector 1 2.2169
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.1097
CERS2 ceramide synthase 2 2.037

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.33015
HMG20B high mobility group 20B -4.98287
CCNB1 cyclin B1 -4.66835
THAP11 THAP domain containing 11 -3.65085
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.51165
RPA3 replication protein A3, 14kDa -3.3044
PSIP1 PC4 and SFRS1 interacting protein 1 -2.99608
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.6804
CORO1A coronin, actin binding protein, 1A -2.5794
CLTB clathrin, light chain B -2.26977
CBR1 carbonyl reductase 1 -2.15455
PANK2 pantothenate kinase 2 -2.11445
DPP6 dipeptidyl-peptidase 6 -2.05715