CRCGN015_MCF10A.TP53.M_24H:H01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 101.47 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

357 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 9.02113
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 6.63619
PYCR1 pyrroline-5-carboxylate reductase 1 6.11686
TXNRD1 thioredoxin reductase 1 5.93669
AARS1 alanyl-tRNA synthetase 1 5.90614
ASNS asparagine synthetase (glutamine-hydrolyzing) 5.30133
AGR2 anterior gradient 2 5.29955
PRAF2 PRA1 domain family, member 2 5.16092
STX1A syntaxin 1A (brain) 5.00043
PHGDH phosphoglycerate dehydrogenase 4.93456
GFPT1 glutamine--fructose-6-phosphate transaminase 1 4.89344
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.69425
GLRX glutaredoxin (thioltransferase) 4.65457
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.49799
HBA1 hemoglobin, alpha 1 4.4408
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.37096
CCDC92 coiled-coil domain containing 92 4.14852
STXBP1 syntaxin binding protein 1 4.09416
HBB hemoglobin, beta 4.02047
PSAT1 phosphoserine aminotransferase 1 3.9815
TRIB3 tribbles pseudokinase 3 3.94563
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.92248
IER3 immediate early response 3 3.8984
HMOX1 heme oxygenase 1 3.83374
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.83101
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.80073
EGR1 early growth response 1 3.79428
XPOT exportin, tRNA 3.76592
SQSTM1 sequestosome 1 3.68528
GARS1 glycyl-tRNA synthetase 1 3.57375
SSBP2 single-stranded DNA binding protein 2 3.54099
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.51879
CDPF1 cysteine-rich, DPF motif domain containing 1 3.50262
CARS1 cysteinyl-tRNA synthetase 1 3.38917
ZMIZ1 zinc finger, MIZ-type containing 1 3.34884
S100A4 S100 calcium binding protein A4 3.34376
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 3.30695
LGMN legumain 3.26073
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 3.255
ATF4 activating transcription factor 4 3.21434
METRN meteorin, glial cell differentiation regulator 3.1523
VSIG2 V-set and immunoglobulin domain containing 2 3.14665
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.05066
CEMIP2 cell migration inducing hyaluronidase 2 3.04842
GRB10 growth factor receptor-bound protein 10 3.04181
FYN FYN proto-oncogene, Src family tyrosine kinase 2.99325
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.97054
SPAG7 sperm associated antigen 7 2.92512
LOC128125814 uncharacterized LOC128125814 2.85426
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.85004
SCCPDH saccharopine dehydrogenase (putative) 2.84389
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.81926
TBX2 T-box 2 2.79166
DUSP6 dual specificity phosphatase 6 2.77563
SARAF store-operated calcium entry-associated regulatory factor 2.7585
SARS1 seryl-tRNA synthetase 1 2.75419
YARS1 tyrosyl-tRNA synthetase 1 2.72248
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.71643
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.66318
NARS1 asparaginyl-tRNA synthetase 1 2.65064
MINDY1 MINDY lysine 48 deubiquitinase 1 2.64282
TRIB1 tribbles pseudokinase 1 2.6258
TARS1 threonyl-tRNA synthetase 1 2.61756
MARS1 methionyl-tRNA synthetase 1 2.61391
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.60814
CHMP4B charged multivesicular body protein 4B 2.60169
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.59773
WFS1 Wolfram syndrome 1 (wolframin) 2.5931
EGR3 early growth response 3 2.56285
IFRD1 interferon-related developmental regulator 1 2.56182
DDIT4 DNA-damage-inducible transcript 4 2.54449
TWF2 twinfilin actin binding protein 2 2.52491
STAMBP STAM binding protein 2.52166
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.48327
NUP133 nucleoporin 133kDa 2.45085
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.41267
RBKS ribokinase 2.41171
SPRY4 sprouty homolog 4 (Drosophila) 2.40704
HDGFL3 HDGF like 3 2.38479
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.37168
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.36328
NUCB2 nucleobindin 2 2.35408
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.33939
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.32459
ATF3 activating transcription factor 3 2.3216
HDLBP high density lipoprotein binding protein 2.29837
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.29637
KCTD5 potassium channel tetramerization domain containing 5 2.27567
INHBE inhibin, beta E 2.27123
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.23836
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.22909
COPB1 coatomer protein complex, subunit beta 1 2.21915
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.20197
HAX1 HCLS1 associated protein X-1 2.19929
ANO10 anoctamin 10 2.19498
ATMIN ATM interactor 2.19268
NIT1 nitrilase 1 2.18222
CREG1 cellular repressor of E1A-stimulated genes 1 2.17513
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 2.17183
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.16902
SKIC2 SKI2 subunit of superkiller complex 2.16621
G0S2 G0/G1 switch 2 2.16554
FICD FIC domain containing 2.14218
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.12785
P3H1 prolyl 3-hydroxylase 1 2.12704
USO1 USO1 vesicle transport factor 2.11982
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.11163
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.09412
PDGFA platelet-derived growth factor alpha polypeptide 2.091
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.0642
AVPI1 arginine vasopressin-induced 1 2.06408
RTN3 reticulon 3 2.05404
CERK ceramide kinase 2.03724
CALU calumenin 2.02979
COPG1 coatomer protein complex, subunit gamma 1 2.0221
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.00092

decreased expression

Symbol Name Standardized Value
DCK deoxycytidine kinase -8.04819
KRT14 keratin 14, type I -6.30234
TUBB6 tubulin, beta 6 class V -6.13586
PSRC1 proline/serine-rich coiled-coil 1 -6.06106
CDC45 cell division cycle 45 -5.97237
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -5.47451
ADRB2 adrenoceptor beta 2, surface -5.35055
MCM3 minichromosome maintenance complex component 3 -5.24808
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.09348
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.61197
RFC2 replication factor C (activator 1) 2, 40kDa -4.42158
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -4.34738
NUP85 nucleoporin 85kDa -4.34583
GRWD1 glutamate-rich WD repeat containing 1 -4.33799
STMN1 stathmin 1 -4.28177
KIF14 kinesin family member 14 -4.27207
SMNDC1 survival motor neuron domain containing 1 -4.23674
BIRC5 baculoviral IAP repeat containing 5 -4.20534
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -4.14575
KIF20A kinesin family member 20A -4.03609
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.98189
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.87158
PCNA proliferating cell nuclear antigen -3.85477
CCDC86 coiled-coil domain containing 86 -3.84017
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.83017
HOXA5 homeobox A5 -3.75907
MCM10 minichromosome maintenance complex component 10 -3.7496
TSPAN4 tetraspanin 4 -3.73285
DNM1L dynamin 1-like -3.72465
UBE2C ubiquitin-conjugating enzyme E2C -3.72359
FEN1 flap structure-specific endonuclease 1 -3.68342
GINS3 GINS complex subunit 3 (Psf3 homolog) -3.67022
CSK c-src tyrosine kinase -3.66625
PRR15L proline rich 15-like -3.65579
CCNA2 cyclin A2 -3.65358
GINS1 GINS complex subunit 1 (Psf1 homolog) -3.62491
CDK1 cyclin-dependent kinase 1 -3.52637
CHAF1A chromatin assembly factor 1, subunit A (p150) -3.52352
CCNB2 cyclin B2 -3.47342
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -3.46179
ASF1B anti-silencing function 1B histone chaperone -3.42606
HMG20B high mobility group 20B -3.40196
PLK1 polo-like kinase 1 -3.40193
RFC3 replication factor C (activator 1) 3, 38kDa -3.39404
CDC25A cell division cycle 25A -3.38099
RAD51AP1 RAD51 associated protein 1 -3.34626
MCM5 minichromosome maintenance complex component 5 -3.29816
DSN1 DSN1, MIS12 kinetochore complex component -3.26518
EXO1 exonuclease 1 -3.25629
SORBS3 sorbin and SH3 domain containing 3 -3.23007
NCAPH non-SMC condensin I complex, subunit H -3.18963
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.18331
NUP93 nucleoporin 93kDa -3.13948
PARP2 poly (ADP-ribose) polymerase 2 -3.12381
KIF18A kinesin family member 18A -3.12106
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.0944
CENPI centromere protein I -3.08367
MORC3 MORC family CW-type zinc finger 3 -3.06943
SPC25 SPC25, NDC80 kinetochore complex component -3.06508
TRIP13 thyroid hormone receptor interactor 13 -3.04718
TTK TTK protein kinase -3.03211
KIF15 kinesin family member 15 -3.02056
CCNF cyclin F -3.01817
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -3.01254
TROAP trophinin associated protein -3.00276
ZNF274 zinc finger protein 274 -2.97899
RAD51 RAD51 recombinase -2.97854
ERCC6L excision repair cross-complementation group 6-like -2.96074
ZNF267 zinc finger protein 267 -2.95241
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.94723
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.94706
PLSCR1 phospholipid scramblase 1 -2.93653
ELOVL6 ELOVL fatty acid elongase 6 -2.93046
CDC6 cell division cycle 6 -2.92976
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.91158
RPA3 replication protein A3, 14kDa -2.90493
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.90289
BID BH3 interacting domain death agonist -2.88576
ORC6 origin recognition complex, subunit 6 -2.87478
PYDC1 PYD (pyrin domain) containing 1 -2.86091
FOXM1 forkhead box M1 -2.85972
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.83722
TLK2 tousled-like kinase 2 -2.81628
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.81322
RGS19 regulator of G-protein signaling 19 -2.80285
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.79305
CDCA8 cell division cycle associated 8 -2.79164
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.79122
MCM7 minichromosome maintenance complex component 7 -2.75779
TK1 thymidine kinase 1, soluble -2.74374
RNF167 ring finger protein 167 -2.74197
GEMIN4 gem (nuclear organelle) associated protein 4 -2.73595
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.73023
VRK1 vaccinia related kinase 1 -2.72896
BRCA1 breast cancer 1, early onset -2.71983
BLM Bloom syndrome, RecQ helicase-like -2.71976
ZDHHC6 zinc finger, DHHC-type containing 6 -2.70959
KIF11 kinesin family member 11 -2.6835
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.68021
ZNF813 zinc finger protein 813 -2.66781
MRPL11 mitochondrial ribosomal protein L11 -2.6616
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.66092
AURKB aurora kinase B -2.6484
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.6246
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.62034
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.61776
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.60824
CISH cytokine inducible SH2-containing protein -2.60569
CLDN8 claudin 8 -2.5696
FANCI Fanconi anemia, complementation group I -2.56153
DSCC1 DNA replication and sister chromatid cohesion 1 -2.55051
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -2.54466
PIMREG PICALM interacting mitotic regulator -2.53466
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.53077
OIP5 Opa interacting protein 5 -2.52888
AMDHD2 amidohydrolase domain containing 2 -2.52778
NEMP1 nuclear envelope integral membrane protein 1 -2.5204
SPDL1 spindle apparatus coiled-coil protein 1 -2.51185
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.50955
POLK polymerase (DNA directed) kappa -2.50342
SINHCAF SIN3-HDAC complex associated factor -2.49231
CENPU centromere protein U -2.48033
ZNF35 zinc finger protein 35 -2.47394
FBXO5 F-box protein 5 -2.4737
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.45894
GMNN geminin, DNA replication inhibitor -2.45301
HSPB1 heat shock 27kDa protein 1 -2.45281
ATAD5 ATPase family, AAA domain containing 5 -2.45267
CEP55 centrosomal protein 55kDa -2.44836
WDR76 WD repeat domain 76 -2.44125
MCM6 minichromosome maintenance complex component 6 -2.4381
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.43174
RBL1 retinoblastoma-like 1 -2.42954
CENPX centromere protein X -2.42198
TRAIP TRAF interacting protein -2.41059
KIF4A kinesin family member 4A -2.40533
TMEM51 transmembrane protein 51 -2.40105
E2F1 E2F transcription factor 1 -2.39983
BAG3 BCL2-associated athanogene 3 -2.39289
RALGDS ral guanine nucleotide dissociation stimulator -2.37666
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.37528
PARPBP PARP1 binding protein -2.3739
NUSAP1 nucleolar and spindle associated protein 1 -2.36631
RIPK4 receptor-interacting serine-threonine kinase 4 -2.36602
ARHGAP11A Rho GTPase activating protein 11A -2.36096
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 -2.34792
NOTCH1 notch 1 -2.3363
NUP107 nucleoporin 107kDa -2.33015
CEP76 centrosomal protein 76kDa -2.32921
FASTKD5 FAST kinase domains 5 -2.32263
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.30544
NDC80 NDC80 kinetochore complex component -2.29364
DCLRE1B DNA cross-link repair 1B -2.28996
CDC7 cell division cycle 7 -2.27315
NCAPG2 non-SMC condensin II complex, subunit G2 -2.27048
SHCBP1 SHC SH2-domain binding protein 1 -2.26995
MCMBP minichromosome maintenance complex binding protein -2.26431
CENPM centromere protein M -2.26052
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.25943
CHEK1 checkpoint kinase 1 -2.25729
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.25108
PRC1 protein regulator of cytokinesis 1 -2.25089
ZNF200 zinc finger protein 200 -2.24325
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.24198
MED21 mediator complex subunit 21 -2.23863
NEK2 NIMA-related kinase 2 -2.23753
CBR3 carbonyl reductase 3 -2.23442
MCM4 minichromosome maintenance complex component 4 -2.22913
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.22868
RTL10 retrotransposon Gag like 10 -2.22196
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.21428
CENPN centromere protein N -2.20812
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.20773
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.20421
BAZ1A bromodomain adjacent to zinc finger domain, 1A -2.19884
STIL SCL/TAL1 interrupting locus -2.19477
KIF23 kinesin family member 23 -2.19324
AUNIP aurora kinase A and ninein interacting protein -2.18325
CORO1A coronin, actin binding protein, 1A -2.18128
FGD2 FYVE, RhoGEF and PH domain containing 2 -2.17867
SRSF2 serine/arginine-rich splicing factor 2 -2.17857
TBC1D10C TBC1 domain family, member 10C -2.17704
FXN frataxin -2.16519
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.16512
MIS18A MIS18 kinetochore protein A -2.16324
HJURP Holliday junction recognition protein -2.15926
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.15438
HOXA4 homeobox A4 -2.15423
CAMTA1 calmodulin binding transcription activator 1 -2.154
CAV1 caveolin 1, caveolae protein, 22kDa -2.1524
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.15232
GAN gigaxonin -2.14641
KIF18B kinesin family member 18B -2.14504
DEPDC1 DEP domain containing 1 -2.14423
TEDC2 tubulin epsilon and delta complex 2 -2.14152
AURKA aurora kinase A -2.14132
SNX10 sorting nexin 10 -2.13431
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.13224
TIPIN TIMELESS interacting protein -2.12997
CENPA centromere protein A -2.12705
SNRPA small nuclear ribonucleoprotein polypeptide A -2.12669
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.11479
TMEM11 transmembrane protein 11 -2.11459
CCDC91 coiled-coil domain containing 91 -2.1125
HOXD9 homeobox D9 -2.10799
KRT15 keratin 15, type I -2.10785
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.10749
BARD1 BRCA1 associated RING domain 1 -2.10726
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.10525
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.09606
ZNF219 zinc finger protein 219 -2.09278
CAPN1 calpain 1, (mu/I) large subunit -2.08582
VANGL1 VANGL planar cell polarity protein 1 -2.07977
TACC3 transforming, acidic coiled-coil containing protein 3 -2.07773
NASP nuclear autoantigenic sperm protein (histone-binding) -2.07731
KRT13 keratin 13, type I -2.07456
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.07411
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.06196
LOC124907012 endogenous retrovirus group K member 7 Env polyprotein-like -2.06009
PSMC3IP PSMC3 interacting protein -2.05896
MSH2 mutS homolog 2 -2.05564
IGFBP6 insulin-like growth factor binding protein 6 -2.05246
BORA bora, aurora kinase A activator -2.0524
ATAD2 ATPase family, AAA domain containing 2 -2.05015
KIFC1 kinesin family member C1 -2.04955
RFC4 replication factor C (activator 1) 4, 37kDa -2.04055
CDCA3 cell division cycle associated 3 -2.03948
RBM14-RBM4 RBM14-RBM4 readthrough -2.03631
IPO8 importin 8 -2.0353
NDC1 NDC1 transmembrane nucleoporin -2.03148
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.02837
MYO19 myosin XIX -2.02654
HOXA10-HOXA9 HOXA10-HOXA9 readthrough -2.01969
CIC capicua transcriptional repressor -2.01563
XPO4 exportin 4 -2.01518
YJU2 YJU2 splicing factor homolog -2.01276
PBK PDZ binding kinase -2.0087
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.00619
TEX30 testis expressed 30 -2.0032
CCNB1 cyclin B1 -2.00275
TLR1 toll-like receptor 1 -2.0008