CRCGN015_MCF10A.TP53.M_24H:H03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 11.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 8.93993
SPAG4 sperm associated antigen 4 5.1911
KCTD5 potassium channel tetramerization domain containing 5 4.90657
CDCA4 cell division cycle associated 4 4.7047
TBX2 T-box 2 3.78624
KLHL9 kelch-like family member 9 3.47317
IGHMBP2 immunoglobulin mu binding protein 2 3.43498
CCL2 chemokine (C-C motif) ligand 2 3.22656
TECR trans-2,3-enoyl-CoA reductase 3.09401
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.00377
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.64027
INTS5 integrator complex subunit 5 2.53999
MRFAP1L1 Morf4 family associated protein 1-like 1 2.41582
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.36294
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.34468
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.32263
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 2.31916
HLA-DRA major histocompatibility complex, class II, DR alpha 2.27128
QDPR quinoid dihydropteridine reductase 2.07402
TEX2 testis expressed 2 2.03392
ARL4D ADP-ribosylation factor-like 4D 2.01038

decreased expression

Symbol Name Standardized Value
HSPA8 heat shock 70kDa protein 8 -5.19062
COG7 component of oligomeric golgi complex 7 -4.70408
HMG20B high mobility group 20B -4.63295
CCNB1 cyclin B1 -4.36915
CD320 CD320 molecule -4.10435
PTK2 protein tyrosine kinase 2 -3.31013
SORBS3 sorbin and SH3 domain containing 3 -2.92698
KATNIP katanin interacting protein -2.80887
BASP1 brain abundant, membrane attached signal protein 1 -2.75915
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.74413
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.7401
RPA3 replication protein A3, 14kDa -2.61734
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.48311
CAND1 cullin-associated and neddylation-dissociated 1 -2.44078
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.40298
SCHIP1 schwannomin interacting protein 1 -2.39855
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.31657
RNFT1-DT RNFT1 divergent transcript -2.27701
MAGEH1 melanoma antigen family H1 -2.25791
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.25136
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.17173
DUSP14 dual specificity phosphatase 14 -2.15456
CSAD cysteine sulfinic acid decarboxylase -2.09548
CENPQ centromere protein Q -2.09187
MYO15A myosin XVA -2.09054
SMIM5 small integral membrane protein 5 -2.07841
UBFD1 ubiquitin family domain containing 1 -2.07241
PRDM13 PR domain containing 13 -2.06706
SGK1 serum/glucocorticoid regulated kinase 1 -2.06642
TENM1 teneurin transmembrane protein 1 -2.04968
LRP1B low density lipoprotein receptor-related protein 1B -2.04407
LOC122539214 Zinc finger protein LOC122539214 -2.0415
COTL1 coactosin-like F-actin binding protein 1 -2.03207
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.01132
TBC1D15 TBC1 domain family, member 15 -2.00857
CFAP69 cilia and flagella associated protein 69 -2.00177