CRCGN015_MCF10A.TP53.M_24H:H04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 99.96 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

126 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 5.3823
KLHDC2 kelch domain containing 2 4.73923
AGR2 anterior gradient 2 4.20469
PPARG peroxisome proliferator-activated receptor gamma 4.07445
FCHO1 FCH domain only 1 3.99619
CNRIP1 cannabinoid receptor interacting protein 1 3.6633
NUCB2 nucleobindin 2 3.61615
HBA1 hemoglobin, alpha 1 3.58129
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.19594
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.18005
EVL Enah/Vasp-like 3.08105
PNKP polynucleotide kinase 3'-phosphatase 2.91856
LYN LYN proto-oncogene, Src family tyrosine kinase 2.75972
STAT5B signal transducer and activator of transcription 5B 2.66732
LGMN legumain 2.61915
STX11 syntaxin 11 2.60925
CCP110 centriolar coiled coil protein 110kDa 2.58524
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.58084
HBB hemoglobin, beta 2.57392
GHR growth hormone receptor 2.55604
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 2.55171
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.50136
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 2.44402
PRR7 proline rich 7 (synaptic) 2.40167
GLRX glutaredoxin (thioltransferase) 2.37411
APOE apolipoprotein E 2.32492
WASF3 WAS protein family, member 3 2.31627
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.29811
BZW2 basic leucine zipper and W2 domains 2 2.29799
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.27392
PDIA6 protein disulfide isomerase family A, member 6 2.25942
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.25163
THAP4 THAP domain containing 4 2.23546
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.23546
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.22693
AGTR1 angiotensin II receptor, type 1 2.14408
NBAS neuroblastoma amplified sequence 2.1163
HMGA2 high mobility group AT-hook 2 2.11063
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough 2.10464
NRDC nardilysin convertase 2.09553
SIX6 SIX homeobox 6 2.09489
EGR1 early growth response 1 2.09448
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.08395
SOX2 SRY (sex determining region Y)-box 2 2.07879
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.06375
ZNF514 zinc finger protein 514 2.05674
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.05274
PSD3 pleckstrin and Sec7 domain containing 3 2.04395
FAF1 Fas (TNFRSF6) associated factor 1 2.04079
APMAP adipocyte plasma membrane associated protein 2.03872
MAMLD1 mastermind-like domain containing 1 2.03601
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.03428
TG thyroglobulin 2.02348
DNAAF11 dynein axonemal assembly factor 11 2.0219
PARP1 poly (ADP-ribose) polymerase 1 2.01232

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -6.32214
TUBA4A tubulin, alpha 4a -5.92274
GRWD1 glutamate-rich WD repeat containing 1 -5.40728
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -4.67358
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.3002
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -4.04294
GOLT1B golgi transport 1B -4.03324
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.97215
CREB1 cAMP responsive element binding protein 1 -3.77199
RNF167 ring finger protein 167 -3.76341
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.75492
COG2 component of oligomeric golgi complex 2 -3.6195
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -3.34288
ADRB2 adrenoceptor beta 2, surface -3.32151
KRT14 keratin 14, type I -3.30578
PFN1 profilin 1 -3.12218
TCEA2 transcription elongation factor A (SII), 2 -3.01786
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.95428
BCL7B B-cell CLL/lymphoma 7B -2.92988
RCOR3 REST corepressor 3 -2.86225
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.84049
EIF5 eukaryotic translation initiation factor 5 -2.8126
KIF18A kinesin family member 18A -2.79187
VDAC1 voltage-dependent anion channel 1 -2.773
CD44 CD44 molecule (Indian blood group) -2.76657
SH3D19 SH3 domain containing 19 -2.74934
SLC35B1 solute carrier family 35, member B1 -2.73261
EXOC5 exocyst complex component 5 -2.65083
YJU2B YJU2 splicing factor homolog B -2.64132
FBXO28 F-box protein 28 -2.54807
FPGS folylpolyglutamate synthase -2.47565
RNASE7 ribonuclease, RNase A family, 7 -2.44509
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.39749
TM9SF3 transmembrane 9 superfamily member 3 -2.39401
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.39235
SGK1 serum/glucocorticoid regulated kinase 1 -2.3742
MPC2 mitochondrial pyruvate carrier 2 -2.34935
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.34036
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.34018
RPS5 ribosomal protein S5 -2.31076
ELOVL6 ELOVL fatty acid elongase 6 -2.30829
ZNF45 zinc finger protein 45 -2.29954
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.29607
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.25743
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.25694
RBM34 RNA binding motif protein 34 -2.24354
CYCS cytochrome c, somatic -2.22832
CIRBP cold inducible RNA binding protein -2.20931
BABAM1 BRISC and BRCA1 A complex member 1 -2.20424
GADD45B growth arrest and DNA-damage-inducible, beta -2.19625
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.15625
INSIG1 insulin induced gene 1 -2.15329
HTD2 hydroxyacyl-thioester dehydratase type 2 -2.13643
HMG20B high mobility group 20B -2.12266
CGRRF1 cell growth regulator with ring finger domain 1 -2.11348
GIN1 gypsy retrotransposon integrase 1 -2.0922
FAM32A family with sequence similarity 32, member A -2.09061
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.0904
MYZAP myocardial zonula adherens protein -2.07777
RFC2 replication factor C (activator 1) 2, 40kDa -2.06569
NLRP2B NLR family pyrin domain containing 2B -2.0567
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.05443
NOTCH1 notch 1 -2.05354
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough -2.05235
PLSCR3 phospholipid scramblase 3 -2.04902
IL17RA interleukin 17 receptor A -2.0378
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.02717
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.02414
PRR15L proline rich 15-like -2.01935
LOC112694756 uncharaterized LOC112694756 -2.01171
ANAPC15 anaphase promoting complex subunit 15 -2.00314