CRCGN015_MCF10A.TP53.M_24H:H05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 33.32 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 7.38541
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 6.13757
AGR2 anterior gradient 2 5.6959
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.21719
SPAG4 sperm associated antigen 4 4.11038
GRB10 growth factor receptor-bound protein 10 4.05251
KIF5C kinesin family member 5C 3.62756
E2F2 E2F transcription factor 2 3.57365
TIMP2 TIMP metallopeptidase inhibitor 2 3.06354
MSRA methionine sulfoxide reductase A 2.9685
BACE2 beta-site APP-cleaving enzyme 2 2.94161
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.91692
AXIN1 axin 1 2.91061
FAM222B family with sequence similarity 222, member B 2.74575
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.67278
MSH5 mutS homolog 5 2.48465
PLS1 plastin 1 2.44049
ITGA7 integrin, alpha 7 2.43603
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.43242
ACOT13 acyl-CoA thioesterase 13 2.3963
NOSIP nitric oxide synthase interacting protein 2.38139
CCNA1 cyclin A1 2.36368
BLTP2 bridge-like lipid transfer protein family member 2 2.33557
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.3159
OARD1 O-acyl-ADP-ribose deacylase 1 2.2181
CCL2 chemokine (C-C motif) ligand 2 2.18064
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.14557
CCDC92 coiled-coil domain containing 92 2.1319
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2.10409
DHDDS dehydrodolichyl diphosphate synthase 2.07718
BCAS3 breast carcinoma amplified sequence 3 2.04055
KIF14 kinesin family member 14 2.01779

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.11014
KIF20A kinesin family member 20A -3.69393
TES testin LIM domain protein -3.62586
HSPA8 heat shock 70kDa protein 8 -3.36533
GRWD1 glutamate-rich WD repeat containing 1 -3.28873
DSG2 desmoglein 2 -3.2871
DIPK1A divergent protein kinase domain 1A -3.15439
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.95875
PCCB propionyl CoA carboxylase, beta polypeptide -2.79506
CHMP4B charged multivesicular body protein 4B -2.76526
TCEA2 transcription elongation factor A (SII), 2 -2.71625
TENT4A terminal nucleotidyltransferase 4A -2.68867
PUF60 poly-U binding splicing factor 60KDa -2.54657
BASP1 brain abundant, membrane attached signal protein 1 -2.48663
ILF2 interleukin enhancer binding factor 2 -2.48326
NVL nuclear VCP-like -2.4828
LRRC41 leucine rich repeat containing 41 -2.46372
ISOC1 isochorismatase domain containing 1 -2.45036
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.37436
GSDMD gasdermin D -2.3131
ZFYVE16 zinc finger, FYVE domain containing 16 -2.29934
OMG oligodendrocyte myelin glycoprotein -2.25138
HSPA12A heat shock 70kDa protein 12A -2.1735
RGS2 regulator of G-protein signaling 2 -2.13143
SUSD5 sushi domain containing 5 -2.1078
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.10524
GTF2B general transcription factor IIB -2.06746