CRCGN015_MCF10A.TP53.M_24H:H07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminostilbene 100.39 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 5.69855
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.4678
FGFR4 fibroblast growth factor receptor 4 4.2762
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.19513
VAV3 vav 3 guanine nucleotide exchange factor 4.09678
NUCB2 nucleobindin 2 4.03725
HMOX1 heme oxygenase 1 3.50985
ACAA1 acetyl-CoA acyltransferase 1 3.37525
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.8921
STRADA STE20-related kinase adaptor alpha 2.6214
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.41218
MCUR1 mitochondrial calcium uniporter regulator 1 2.3552
EFHC1 EF-hand domain (C-terminal) containing 1 2.1814
ECH1 enoyl CoA hydratase 1, peroxisomal 2.073
RAI14 retinoic acid induced 14 2.0704
SOAT2 sterol O-acyltransferase 2 2.03438
NOSIP nitric oxide synthase interacting protein 2.0224
TSPAN15 tetraspanin 15 2.0186

decreased expression

Symbol Name Standardized Value
CD81 CD81 molecule -2.9295
GRWD1 glutamate-rich WD repeat containing 1 -2.31025
FFAR2 free fatty acid receptor 2 -2.2952
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.28725
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.23125
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.20563
RPS5 ribosomal protein S5 -2.15875
ADAMTSL3 ADAMTS-like 3 -2.1238
IL17RA interleukin 17 receptor A -2.06545
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.03975