CRCGN015_MCF10A.TP53.M_24H:H08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminostilbene 33.46 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

148 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.20265
STIMATE STIM activating enhancer 5.01045
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.70475
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.41555
ADAT1 adenosine deaminase, tRNA-specific 1 3.77215
AXIN1 axin 1 3.7402
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 3.39605
HBB hemoglobin, beta 3.3347
TIAM1 T-cell lymphoma invasion and metastasis 1 3.30555
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.17005
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.11075
F8A2 coagulation factor VIII-associated 2 3.0326
MMP8 matrix metallopeptidase 8 2.9758
TMEM231 transmembrane protein 231 2.82148
AGR2 anterior gradient 2 2.70235
NFIL3 nuclear factor, interleukin 3 regulated 2.6778
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.6049
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 2.5979
NUCB2 nucleobindin 2 2.51925
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.4879
IARS1 isoleucyl-tRNA synthetase 1 2.48245
OVOL2 ovo-like zinc finger 2 2.42695
ABHD4 abhydrolase domain containing 4 2.39185
TEAD3 TEA domain family member 3 2.37635
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.3744
KIF20A kinesin family member 20A 2.3683
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.36697
BPHL biphenyl hydrolase-like (serine hydrolase) 2.3619
GPC4 glypican 4 2.32648
GPR88 G protein-coupled receptor 88 2.2769
DEFA3 defensin, alpha 3, neutrophil-specific 2.27125
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.2628
PLPP6 phospholipid phosphatase 6 2.24575
VAMP7 vesicle-associated membrane protein 7 2.20725
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.2045
TROAP trophinin associated protein 2.19545
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 2.1666
STOM stomatin 2.13258
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.11825
HAGH hydroxyacylglutathione hydrolase 2.10865
NRSN2 neurensin 2 2.101
SYNGR2 synaptogyrin 2 2.1006
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2.09457
PDZD8 PDZ domain containing 8 2.09075
TBPL1 TBP-like 1 2.07455
GADD45G growth arrest and DNA-damage-inducible, gamma 2.07335
PIERCE1 piercer of microtubule wall 1 2.07272
RNF43 ring finger protein 43 2.0679
PALB2 partner and localizer of BRCA2 2.0678
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.04605
ZNF76 zinc finger protein 76 2.0459
MX2 MX dynamin-like GTPase 2 2.0398
ELF4 E74-like factor 4 (ets domain transcription factor) 2.02673
LTN1 listerin E3 ubiquitin protein ligase 1 2.01895
SLC35A5 solute carrier family 35, member A5 2.01745
ZNF322 zinc finger protein 322 2.01435
AGO2 argonaute RISC catalytic component 2 2.00655
BIK BCL2-interacting killer (apoptosis-inducing) 2.0039
HBA1 hemoglobin, alpha 1 2.00359
MAGEA11 melanoma antigen family A11 2.00295
ZNF443 zinc finger protein 443 2.00155
HMOX1 heme oxygenase 1 2.0008

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -5.89605
HSPA8 heat shock 70kDa protein 8 -5.6036
OXA1L oxidase (cytochrome c) assembly 1-like -5.3939
DSG2 desmoglein 2 -5.1201
HAT1 histone acetyltransferase 1 -5.1009
TRAPPC3 trafficking protein particle complex 3 -4.99067
TUBB6 tubulin, beta 6 class V -4.8657
TM9SF3 transmembrane 9 superfamily member 3 -4.8124
CTNND1 catenin (cadherin-associated protein), delta 1 -4.64373
ANXA2 annexin A2 -4.52793
SSB Sjogren syndrome antigen B (autoantigen La) -3.54973
RBM34 RNA binding motif protein 34 -3.44805
GRWD1 glutamate-rich WD repeat containing 1 -3.4221
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.2341
SORBS3 sorbin and SH3 domain containing 3 -2.97228
SAV1 salvador family WW domain containing protein 1 -2.82235
CCDC68 coiled-coil domain containing 68 -2.78735
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.737
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.7223
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.63235
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.58355
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.53825
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 -2.53005
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.52145
PYGL phosphorylase, glycogen, liver -2.4372
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.3955
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.3838
EIF3H eukaryotic translation initiation factor 3, subunit H -2.36005
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.34405
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -2.331
WAPL WAPL cohesin release factor -2.33022
MACROD1 MACRO domain containing 1 -2.32685
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.32622
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.3243
RTN3 reticulon 3 -2.30115
KCTD7 potassium channel tetramerization domain containing 7 -2.294
PRRX1 paired related homeobox 1 -2.2929
BMP6 bone morphogenetic protein 6 -2.28765
TSG101 tumor susceptibility 101 -2.27345
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.26605
RRM1 ribonucleotide reductase M1 -2.26207
PLSCR4 phospholipid scramblase 4 -2.2571
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -2.24975
LBHD1 LBH domain containing 1 -2.2242
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.21995
TRIM9 tripartite motif containing 9 -2.2013
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.19397
ZMYM4 zinc finger, MYM-type 4 -2.19263
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -2.17975
LIMD1 LIM domains containing 1 -2.17685
ATP11B ATPase, class VI, type 11B -2.174
CRTAP cartilage associated protein -2.17035
CAPN2 calpain 2, (m/II) large subunit -2.16293
PNMA8A PNMA family member 8A -2.15095
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.14615
INPP5B inositol polyphosphate-5-phosphatase, 75kDa -2.13427
IMMT inner membrane protein, mitochondrial -2.12865
FBL fibrillarin -2.12015
BCL2L2 BCL2-like 2 -2.11995
PALM2AKAP2 PALM2 and AKAP2 fusion -2.11733
UNC119B unc-119 homolog B (C. elegans) -2.11045
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -2.102
TSPAN8 tetraspanin 8 -2.09755
FSCN1 fascin actin-bundling protein 1 -2.09022
RPL22 ribosomal protein L22 -2.08438
MRPS15 mitochondrial ribosomal protein S15 -2.0816
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.07135
NHLRC2 NHL repeat containing 2 -2.06845
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.06525
CALCB calcitonin-related polypeptide beta -2.05155
INTS14 integrator complex subunit 14 -2.0434
CLASRP CLK4-associating serine/arginine rich protein -2.03675
GSTK1 glutathione S-transferase kappa 1 -2.0337
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.03265
DMAC2 distal membrane arm assembly component 2 -2.02975
GGPS1 geranylgeranyl diphosphate synthase 1 -2.02965
DEPDC5 DEP domain containing 5 -2.02385
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.01925
ADGRE2 adhesion G protein-coupled receptor E2 -2.01855
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.01615
MGA MGA, MAX dimerization protein -2.01585
IPO7 importin 7 -2.01334
PDIA3 protein disulfide isomerase family A, member 3 -2.0132
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.01257
FEN1 flap structure-specific endonuclease 1 -2.0123
RIC8A RIC8 guanine nucleotide exchange factor A -2.0107