CRCGN015_MCF10A.TP53.M_24H:H10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description maleic hydrazide 99.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 5.54495
MAMLD1 mastermind-like domain containing 1 5.35545
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.31189
CCDC92 coiled-coil domain containing 92 5.0885
HYOU1 hypoxia up-regulated 1 4.9981
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.78905
SPAG4 sperm associated antigen 4 4.58475
TBX2 T-box 2 3.88267
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.35415
TRIM24 tripartite motif containing 24 2.84307
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.7605
ARCN1 archain 1 2.75875
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.73125
WIF1 WNT inhibitory factor 1 2.6974
NUP205 nucleoporin 205kDa 2.68095
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.62775
KLHDC10 kelch domain containing 10 2.51997
TENT5C terminal nucleotidyltransferase 5C 2.46655
CADM1 cell adhesion molecule 1 2.44953
COPS7A COP9 signalosome subunit 7A 2.42395
BOLA2B bolA family member 2B 2.36405
UPK3B uroplakin 3B 2.35695
UIMC1 ubiquitin interaction motif containing 1 2.32485
SGPP1 sphingosine-1-phosphate phosphatase 1 2.29865
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.2745
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.27445
ODF2 outer dense fiber of sperm tails 2 2.2419
HELZ helicase with zinc finger 2.22855
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.21065
YBX3 Y box binding protein 3 2.20355
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.1985
CA10 carbonic anhydrase X 2.19765
PCF11 PCF11 cleavage and polyadenylation factor subunit 2.1884
RFX7 regulatory factor X, 7 2.18095
PXMP2 peroxisomal membrane protein 2, 22kDa 2.1387
RDX radixin 2.1351
RAB22A RAB22A, member RAS oncogene family 2.08358
FAM114A2 family with sequence similarity 114, member A2 2.06525
BMP6 bone morphogenetic protein 6 2.0594
ZEB2 zinc finger E-box binding homeobox 2 2.04915
TUBG1 tubulin, gamma 1 2.0296
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.0276
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2.02475
MDFIC MyoD family inhibitor domain containing 2.0237
ATP5MF ATP synthase membrane subunit f 2.00195

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.9635
CHMP4B charged multivesicular body protein 4B -5.71428
PARP2 poly (ADP-ribose) polymerase 2 -5.3915
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.21085
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -5.10873
ATF5 activating transcription factor 5 -4.45255
OXA1L oxidase (cytochrome c) assembly 1-like -4.1266
KRT14 keratin 14, type I -3.5242
METTL17 methyltransferase like 17 -3.4465
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.42322
OSGEP O-sialoglycoprotein endopeptidase -3.29795
FAM32A family with sequence similarity 32, member A -3.27325
NT5DC2 5'-nucleotidase domain containing 2 -3.16595
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -3.1114
PRMT5 protein arginine methyltransferase 5 -3.08125
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.91245
GMPR2 guanosine monophosphate reductase 2 -2.86705
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.81445
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.6738
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.66815
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.6639
MMP11 matrix metallopeptidase 11 -2.6371
CCNL1 cyclin L1 -2.62495
TIMP1 TIMP metallopeptidase inhibitor 1 -2.60225
NGDN neuroguidin, EIF4E binding protein -2.58573
SALL2 spalt-like transcription factor 2 -2.5438
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.5014
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.4879
MPC2 mitochondrial pyruvate carrier 2 -2.4756
NKAIN1 Na+/K+ transporting ATPase interacting 1 -2.4615
ASB13 ankyrin repeat and SOCS box containing 13 -2.44005
BCL2L2 BCL2-like 2 -2.43425
SPAG16 sperm associated antigen 16 -2.43205
GTPBP3 GTP binding protein 3 (mitochondrial) -2.4294
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.416
MRPL58 mitochondrial ribosomal protein L58 -2.3713
FES FES proto-oncogene, tyrosine kinase -2.3443
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.3381
SIN3B SIN3 transcription regulator family member B -2.32875
PAQR4 progestin and adipoQ receptor family member IV -2.3008
IRS1 insulin receptor substrate 1 -2.28555
CAPN15 calpain 15 -2.256
METTL3 methyltransferase like 3 -2.2532
AUNIP aurora kinase A and ninein interacting protein -2.24745
ANG angiogenin, ribonuclease, RNase A family, 5 -2.21765
HPN hepsin -2.21195
TBX3 T-box 3 -2.20395
DAD1 defender against cell death 1 -2.1874
ZFHX4 zinc finger homeobox 4 -2.18485
LCE2B late cornified envelope 2B -2.17925
ZNF133 zinc finger protein 133 -2.16353
DVL1 dishevelled segment polarity protein 1 -2.16115
RNF31 ring finger protein 31 -2.1475
ZC4H2 zinc finger, C4H2 domain containing -2.14725
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.1429
KHNYN KH and NYN domain containing -2.13613
KIF16B kinesin family member 16B -2.1302
LIMD2 LIM domain containing 2 -2.1249
POF1B premature ovarian failure, 1B -2.12445
CDK20 cyclin-dependent kinase 20 -2.1186
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 -2.1161
PI15 peptidase inhibitor 15 -2.1109
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.08615
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.0855
COL1A2 collagen, type I, alpha 2 -2.0835
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.07665
TEAD3 TEA domain family member 3 -2.05395
CHD8 chromodomain helicase DNA binding protein 8 -2.0497
TM9SF1 transmembrane 9 superfamily member 1 -2.0349
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -2.02275
PLIN2 perilipin 2 -2.0171
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -2.0147
KLK1 kallikrein 1 -2.01345
ZNF32 zinc finger protein 32 -2.0061
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.00605
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 -2.00435