CRCGN015_MCF10A.TP53.M_24H:H12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description maleic hydrazide 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UGDH UDP-glucose 6-dehydrogenase 4.89825
SNX11 sorting nexin 11 3.74302
CERK ceramide kinase 3.6699
ELAC2 elaC ribonuclease Z 2 3.51275
BDH1 3-hydroxybutyrate dehydrogenase, type 1 3.1462
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.75785
BACE2 beta-site APP-cleaving enzyme 2 2.61245
AHCYL1 adenosylhomocysteinase-like 1 2.4644
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.4361
RBBP4 retinoblastoma binding protein 4 2.4322
WDR7 WD repeat domain 7 2.41855
EED embryonic ectoderm development 2.41305
H2AZ2 H2A.Z variant histone 2 2.36327
TMEM47 transmembrane protein 47 2.35995
NOTCH1 notch 1 2.35235
RBM23 RNA binding motif protein 23 2.3075
COL15A1 collagen, type XV, alpha 1 2.2844
HARS1 histidyl-tRNA synthetase 1 2.2825
YBX1 Y box binding protein 1 2.25545
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.25392
GSTM5 glutathione S-transferase mu 5 2.2492
HDAC1 histone deacetylase 1 2.2306
PCNA proliferating cell nuclear antigen 2.2184
NECTIN4 nectin cell adhesion molecule 4 2.2002
MTUS1 microtubule associated tumor suppressor 1 2.196
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.14375
PRSS3 protease, serine, 3 2.14348
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.14055
PRSS2 protease, serine, 2 (trypsin 2) 2.11475
LOC128031832 uncharacterized LOC128031832 2.11205
BLMH bleomycin hydrolase 2.10255
PRH1 proline-rich protein HaeIII subfamily 1 2.1018
NOSIP nitric oxide synthase interacting protein 2.0825
EBNA1BP2 EBNA1 binding protein 2 2.06805
FTO fat mass and obesity associated 2.03815
KIFAP3 kinesin-associated protein 3 2.03375
NECAP1 NECAP endocytosis associated 1 2.01795
FER fer (fps/fes related) tyrosine kinase 2.0169
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.01415

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -10.0
TCTA T-cell leukemia translocation altered -4.94315
CAB39 calcium binding protein 39 -4.86975
UFM1 ubiquitin-fold modifier 1 -4.6999
YME1L1 YME1-like 1 ATPase -4.5497
MRPS16 mitochondrial ribosomal protein S16 -4.52135
SORBS3 sorbin and SH3 domain containing 3 -3.693
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -3.47515
EIF5B eukaryotic translation initiation factor 5B -3.43848
UNC50 unc-50 homolog (C. elegans) -3.4321
SHROOM2 shroom family member 2 -3.24855
CHST10 carbohydrate sulfotransferase 10 -3.0232
TMEM127 transmembrane protein 127 -2.84215
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.80018
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.6799
TZMP1 transition zone microprotein 1 -2.6554
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.64655
NOP10 NOP10 ribonucleoprotein -2.6334
PAOX polyamine oxidase (exo-N4-amino) -2.59548
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.5601
SGK1 serum/glucocorticoid regulated kinase 1 -2.4512
ZNF514 zinc finger protein 514 -2.4291
LIPT1 lipoyltransferase 1 -2.41625
EMC10 ER membrane protein complex subunit 10 -2.3692
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.35005
FICD FIC domain containing -2.33305
PDCL3 phosducin-like 3 -2.3211
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.3126
PANK2 pantothenate kinase 2 -2.3017
LMAN2L lectin, mannose-binding 2-like -2.26955
DCAF4 DDB1 and CUL4 associated factor 4 -2.25155
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.23515
MLH1 mutL homolog 1 -2.21775
MATN3 matrilin 3 -2.216
MYBPH myosin binding protein H -2.18625
GPC4 glypican 4 -2.1807
BEAN1 brain expressed, associated with NEDD4, 1 -2.16015
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -2.1599
EXTL1 exostosin-like glycosyltransferase 1 -2.1556
OSGIN2 oxidative stress induced growth inhibitor family member 2 -2.14775
CCDC106 coiled-coil domain containing 106 -2.14325
PCDHA10 protocadherin alpha 10 -2.14285
TOLLIP toll interacting protein -2.13255
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -2.1077
COX5B cytochrome c oxidase subunit Vb -2.09827
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -2.09365
OR51E2 olfactory receptor, family 51, subfamily E, member 2 -2.08845
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.0686
OR12D3 olfactory receptor, family 12, subfamily D, member 3 -2.05815
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.05675
RLN2 relaxin 2 -2.05505
MPPED1 metallophosphoesterase domain containing 1 -2.0536
TMEM59L transmembrane protein 59-like -2.05145
CCN2 cellular communication network factor 2 -2.04045
DRC11 dynein regulatory complex subunit 11 -2.0384
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.03375
CIAO1 cytosolic iron-sulfur assembly component 1 -2.025
AMH anti-Mullerian hormone -2.0133
GPR173 G protein-coupled receptor 173 -2.0048
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.0012