CRCGN015_MCF10A.TP53.M_24H:H14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl methacrylate 32.81 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 5.36405
GPER1 G protein-coupled estrogen receptor 1 4.51163
MAP7 microtubule-associated protein 7 4.49763
CCDC85B coiled-coil domain containing 85B 4.148
LYRM1 LYR motif containing 1 3.74165
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.7136
HBA1 hemoglobin, alpha 1 3.32764
HSPA1A heat shock 70kDa protein 1A 3.0239
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.81145
COMP cartilage oligomeric matrix protein 2.701
BAMBI BMP and activin membrane-bound inhibitor 2.694
CNRIP1 cannabinoid receptor interacting protein 1 2.6683
CYFIP2 cytoplasmic FMR1 interacting protein 2 2.59268
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.5907
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.50295
OLFML2B olfactomedin-like 2B 2.4884
AGR2 anterior gradient 2 2.47505
CD47 CD47 molecule 2.42382
FAR2 fatty acyl CoA reductase 2 2.39825
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 2.39005
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.3251
NINJ2 ninjurin 2 2.28475
PXMP2 peroxisomal membrane protein 2, 22kDa 2.26525
THTPA thiamine triphosphatase 2.2617
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 2.2421
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 2.24082
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.22525
DXO decapping exoribonuclease 2.21975
ATP13A2 ATPase type 13A2 2.185
TPGS1 tubulin polyglutamylase complex subunit 1 2.16475
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.15905
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.14425
PHF10 PHD finger protein 10 2.125
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.10117
CYTL1 cytokine-like 1 2.077
KLHDC4 kelch domain containing 4 2.0636
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.04945
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B 2.04125
EXD2 exonuclease 3'-5' domain containing 2 2.03435
LDHA lactate dehydrogenase A 2.02615
CAMTA2 calmodulin binding transcription activator 2 2.02405
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.01765
ZC2HC1C zinc finger, C2HC-type containing 1C 2.0119

decreased expression

Symbol Name Standardized Value
ANXA2 annexin A2 -6.24527
KRT14 keratin 14, type I -6.21475
UFM1 ubiquitin-fold modifier 1 -5.0
PRPF4 pre-mRNA processing factor 4 -4.9391
RPA3 replication protein A3, 14kDa -4.74055
HAT1 histone acetyltransferase 1 -4.683
TUBB6 tubulin, beta 6 class V -4.35655
COG7 component of oligomeric golgi complex 7 -4.27215
RPS5 ribosomal protein S5 -4.037
CBR3 carbonyl reductase 3 -3.32615
RBM34 RNA binding motif protein 34 -3.29378
BFAR bifunctional apoptosis regulator -3.1592
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -3.12925
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.10205
FAIM Fas apoptotic inhibitory molecule -3.01295
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.89345
TBC1D2 TBC1 domain family, member 2 -2.78755
MPHOSPH8 M-phase phosphoprotein 8 -2.7683
TUBGCP5 tubulin, gamma complex associated protein 5 -2.6149
TRIM56 tripartite motif containing 56 -2.54165
MRPS31 mitochondrial ribosomal protein S31 -2.50627
CIRSR corepressor of RBPJ and splicing regulator -2.4823
CDCA4 cell division cycle associated 4 -2.44075
LMBR1L limb development membrane protein 1-like -2.4341
SOWAHC sosondowah ankyrin repeat domain family member C -2.4137
PIBF1 progesterone immunomodulatory binding factor 1 -2.38765
GMPPA GDP-mannose pyrophosphorylase A -2.36695
CAPN2 calpain 2, (m/II) large subunit -2.33257
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.3321
NANS N-acetylneuraminic acid synthase -2.30715
DCTN5 dynactin 5 (p25) -2.29577
CREB3L2 cAMP responsive element binding protein 3-like 2 -2.29055
ZNF611 zinc finger protein 611 -2.2893
DSN1 DSN1, MIS12 kinetochore complex component -2.2819
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.27117
TRIP10 thyroid hormone receptor interactor 10 -2.2594
KRT5 keratin 5, type II -2.2346
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.22995
ALAD aminolevulinate dehydratase -2.225
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.21865
LCMT1 leucine carboxyl methyltransferase 1 -2.2152
SMC5 structural maintenance of chromosomes 5 -2.20512
ULBP2 UL16 binding protein 2 -2.1906
SURF2 surfeit 2 -2.167
SQSTM1 sequestosome 1 -2.1577
HIRIP3 HIRA interacting protein 3 -2.1569
SAP30BP SAP30 binding protein -2.1557
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.14773
TNNI2 troponin I type 2 (skeletal, fast) -2.1221
SSB Sjogren syndrome antigen B (autoantigen La) -2.11035
PALB2 partner and localizer of BRCA2 -2.10165
SMYD5 SMYD family member 5 -2.09955
DENND5B DENN/MADD domain containing 5B -2.08435
NMRK2 nicotinamide riboside kinase 2 -2.0793
FTL ferritin, light polypeptide -2.07008
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.06525
P3H3 prolyl 3-hydroxylase 3 -2.06395
CD9 CD9 molecule -2.0574
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -2.05364
ZNF426 zinc finger protein 426 -2.0493
CLEC2D C-type lectin domain family 2, member D -2.04875
ELP3 elongator acetyltransferase complex subunit 3 -2.04785
TTF1 transcription termination factor, RNA polymerase I -2.04537
ZNF136 zinc finger protein 136 -2.03355
MCC mutated in colorectal cancers -2.02935
ADAMTSL4 ADAMTS-like 4 -2.0271
MILR1 mast cell immunoglobulin-like receptor 1 -2.01965
TUBA4A tubulin, alpha 4a -2.01635
EFS embryonal Fyn-associated substrate -2.011
MBTD1 mbt domain containing 1 -2.01055
TEP1 telomerase-associated protein 1 -2.00315