CRCGN015_MCF10A.TP53.M_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 99.45 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.76665
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.71203
HBA1 hemoglobin, alpha 1 4.62975
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.5522
CXCR4 chemokine (C-X-C motif) receptor 4 4.4781
SNX11 sorting nexin 11 4.17212
ACAA1 acetyl-CoA acyltransferase 1 3.6426
KDM5A lysine (K)-specific demethylase 5A 3.48195
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.08298
HBB hemoglobin, beta 2.93003
KLHL9 kelch-like family member 9 2.84537
AGR2 anterior gradient 2 2.7553
FBXO7 F-box protein 7 2.7187
TIAM1 T-cell lymphoma invasion and metastasis 1 2.71683
PECR peroxisomal trans-2-enoyl-CoA reductase 2.64445
CADM1 cell adhesion molecule 1 2.59758
MREG melanoregulin 2.3236
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.29
MCUR1 mitochondrial calcium uniporter regulator 1 2.25015
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.20525
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.203
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.1726
SLC75A1 solute carrier family 75 member 1 2.1245
SFTPB surfactant protein B 2.08975
ERAP2 endoplasmic reticulum aminopeptidase 2 2.05265
CNIH1 cornichon family AMPA receptor auxiliary protein 1 2.02715
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.00425

decreased expression

Symbol Name Standardized Value
TCTA T-cell leukemia translocation altered -5.7554
HMG20B high mobility group 20B -4.8197
CLTB clathrin, light chain B -3.73305
SPINK4 serine peptidase inhibitor, Kazal type 4 -3.64045
CLCA1 chloride channel accessory 1 -3.4355
SGK1 serum/glucocorticoid regulated kinase 1 -3.1905
EPHB6 EPH receptor B6 -2.7046
ANKRD40CL ANKRD40 C-terminal like -2.67735
KRT14 keratin 14, type I -2.60355
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.60103
ATOH1 atonal homolog 1 (Drosophila) -2.5656
TUBB4A tubulin, beta 4A class IVa -2.55065
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.51237
CCL24 chemokine (C-C motif) ligand 24 -2.48595
RNF44 ring finger protein 44 -2.43825
MUC2 mucin 2, oligomeric mucus/gel-forming -2.4234
PIGR polymeric immunoglobulin receptor -2.3795
DUOX2 dual oxidase 2 -2.3669
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -2.3174
GCG glucagon -2.31685
MFSD12 major facilitator superfamily domain containing 12 -2.30942
RNF186 ring finger protein 186 -2.30015
CHP2 calcineurin-like EF-hand protein 2 -2.2155
TESPA1 thymocyte expressed, positive selection associated 1 -2.20925
BEST2 bestrophin 2 -2.1938
CLCA4 chloride channel accessory 4 -2.18335
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -2.1628
PIH1D1 PIH1 domain containing 1 -2.15745
PEX5L peroxisomal biogenesis factor 5-like -2.1551
ZG16 zymogen granule protein 16 -2.1246
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.0947
KRT20 keratin 20, type I -2.03835
BTNL8 butyrophilin-like 8 -2.03365
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -2.0321
HOXB9 homeobox B9 -2.01585