CRCGN015_MCF10A.TP53.M_24H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 33.15 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.619
SSBP2 single-stranded DNA binding protein 2 5.06878
RAP1GAP RAP1 GTPase activating protein 5.05545
ADGRE5 adhesion G protein-coupled receptor E5 4.7989
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.6114
CNRIP1 cannabinoid receptor interacting protein 1 3.7215
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.5529
ACAA1 acetyl-CoA acyltransferase 1 3.5126
BACE2 beta-site APP-cleaving enzyme 2 3.21485
TLCD3A TLC domain containing 3A 3.10935
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.93763
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.8217
ADRB2 adrenoceptor beta 2, surface 2.1945

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -5.4417
CCNB1 cyclin B1 -5.3199
SLC25A46 solute carrier family 25, member 46 -5.05555
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.70725
BASP1 brain abundant, membrane attached signal protein 1 -4.2446
CANT1 calcium activated nucleotidase 1 -4.11172
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.79085
KRT14 keratin 14, type I -2.4258
ZMYM2 zinc finger, MYM-type 2 -2.20792
ATP11B ATPase, class VI, type 11B -2.08055
BEST1 bestrophin 1 -2.077
GRN granulin -2.07245
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.06153
TNPO1 transportin 1 -2.02219
ZBTB22 zinc finger and BTB domain containing 22 -2.00915